Index Catalog // ScholarsArchive@OSU

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

Creator:: Osborn, Andrew
Abstract:: Sugar phosphate cyclases (SPCs) are enzymes involved in the biosynthesis of many important natural products. SPCs form a unique cyclitol during the early steps in the biosynthesis of many natural products. These natural products include rifamycin, which is chemically modified to rifampicin and used clinically as an antituberculosis drug, and...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Andrew Osborn

The role of costimulation and adjuvants in the development of T cell effector and memory responses

Creator:: Maxwell, Joseph R.
Abstract:: T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Joseph R. Maxwell for the degree

The influence of aryl hydrocarbon receptor activation on T cell fate

Creator:: Funatake, Castle J.
Abstract:: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
Resource Type:: Dissertation
Full Text:: Hydrocarbon Receptor Activation on T Cell Fate. approved: 2,3,7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and

"They called me the hyacinth girl" : T. S. Eliot, masculinity, and the Great War

Creator:: Query, Patrick
Abstract:: This thesis traces the relationship between the First World War, constructions of masculinity, and the life and poetry of T.S. Eliot. Central to this relationship is a study of homoeroticism, which the author characterizes as different from homosexuality but not exclusive of it, in late 19th and early 20th century...
Resource Type:: Masters Thesis
Full Text:: "They called me the hyacinth girl" : T. S. Eliot, masculinity

Uncovering the mechanism of IL-4-mediated T cell survival

Creator:: Moscibrocki, Cathleen M.
Abstract:: Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
Resource Type:: Masters Thesis
Full Text:: of IL-4-mediated T Cell Survival. Abstract approved: Anthony T. Vella Although IL-4 is a well

De novo synthesis of a sunscreen compound in vertebrates

Creator:: Osborn, Andrew R., Almabruk, Khaled H., Holzwarth, Garrett, Asamizu, Shumpei, LaDu, Jane, Kean, Kelsey M., Karplus, P. Andrew, Tanguay, Robert L., Bakalinsky, Alan T., and Mahmud, Taifo
Abstract:: Ultraviolet-protective compounds, such as mycosporine-like amino acids (MAAs) and related gadusols produced by some bacteria, fungi, algae, and marine invertebrates, are critical for the survival of reef-building corals and other marine organisms exposed to high-solar irradiance. These compounds have also been found in marine fish, where their accumulation is thought...
Resource Type:: Article
Full Text:: sunscreen compound in vertebrates De novo synthesis of a sunscreen compound in vertebrates Osborn, A. R

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

Creator:: Marshall, Nikki B.
Abstract:: The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
Resource Type:: Dissertation
Full Text:: Microbiology presented on December 1, 2009. Title: Investigations of Regulatory T cell Induction by 2, 3, 7

"Land of War and Blood" : spectacular violence, conflicting medievalisms, and chivalric legacies in Sir Walter Scott's Ivanhoe, Mark Twain's A Connecticut Yankee in King Arthur's Court, and George R.R. Martin's A Game of Thrones

Creator:: Horton, Kaely
Abstract:: This thesis examines depictions of medievalism in three central texts: Sir Walter Scott's Ivanhoe, Mark Twain's A Connecticut Yankee in King Arthur's Court, and George R.R. Martin's A Game of Thrones. Each of these texts provides an entry point for exploring the ways in which English and American writers have...
Resource Type:: Masters Thesis
Full Text:: George R. R. Martin’s A Game of Thrones

Family-Teacher Relationships and Child Engagement in Early Care and Education

Creator:: Lewis, Hillary R.
Abstract:: The interactions young children have with teachers, peers, and tasks in early care and education (ECE) settings support development of social and academic skills. The degree to which families and teachers partner to support children’s development may contribute to child engagement. The current study aims to expand our understanding of...
Resource Type:: Masters Thesis
Full Text:: THESIS OF Hillary R. Lewis for the degree of Master of Science in Human Development and Family

Predictors of Family-Teacher Relationship Quality in Early Care and Education: Type of ECE Program, Family Socioeconomic Status and Adverse Childhood Experiences

Creator:: Lewis, Hillary R.
Abstract:: Families and early care and education (ECE) programs are two important contexts in which young children develop (Bronfenbrenner & Morris, 2006). Nearly half of all preschoolers are cared for in nonrelative care (e.g. child care center, preschool, Head Start, teacher’s home; Laughlin, 2013), and ECE programs have the potential to...
Resource Type:: Dissertation
Full Text:: THE DISSERTATION OF Hillary R. Lewis for the degree of Doctor of Philosophy in Human Development

ScholarsArchive@OSU

Evolutionary and Biochemical Studies of C₇-cyclitol Synthases and their Sunscreen Gene Clusters

The role of costimulation and adjuvants in the development of T cell effector and memory responses

The influence of aryl hydrocarbon receptor activation on T cell fate

"They called me the hyacinth girl" : T. S. Eliot, masculinity, and the Great War

Uncovering the mechanism of IL-4-mediated T cell survival

De novo synthesis of a sunscreen compound in vertebrates

Investigations of regulatory T cell induction by 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin during a graft-versus-host response

"Land of War and Blood" : spectacular violence, conflicting medievalisms, and chivalric legacies in Sir Walter Scott's Ivanhoe, Mark Twain's A Connecticut Yankee in King Arthur's Court, and George R.R. Martin's A Game of Thrones

Family-Teacher Relationships and Child Engagement in Early Care and Education

Predictors of Family-Teacher Relationship Quality in Early Care and Education: Type of ECE Program, Family Socioeconomic Status and Adverse Childhood Experiences

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