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  • Studies of non-mevalonate isoprenoid biosynthesis : the 1-deoxy-D-xylulose-5-phosphate isomeroreductase (DXR) mediated reaction

    Creator:
    Woo, Youn-Hi
    Abstract:
    This dissertation details the investigation of an alternate pathway to isoprenoids that occurs in plants and microorganisms, the non-mevalonate pathway. This exploration of the pathway focuses on the second step, the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methylerythritol-4-phosphate (MEP) by the enzyme DXP isomeroreductase (DXR). These studies led to an appreciation...
    Resource Type:
    Dissertation
    Full Text:
    , Dr. Phil Proteau for his support, continual inspiration, and endless patience as a mentor, in

  • Studies on isoprenoid biosynthesis in Euglena gracilis

    Creator:
    Kim, Dojung
    Abstract:
    This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
    Resource Type:
    Dissertation
    Full Text:
    thank my major Professor, Philip J. Proteau, for his support, guidance, and patience throughout my

  • Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

    Creator:
    Phaosiri, Chanokporn
    Abstract:
    The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...
    Resource Type:
    Dissertation
    Full Text:
    foremost, II would like to thank my major professor, Dr. Philip Proteau for his advice, guidance, and

  • Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

    Creator:
    Fernandes, Roberta P. M.
    Abstract:
    In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...
    Resource Type:
    Dissertation
    Full Text:
    Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP

  • Biosynthetic studies of fungal diterpene antibiotics

    Creator:
    Yao, Qingmei
    Abstract:
    The isoprenoid pathway is one of the major biosynthetic pathways of secondary metabolites. Isoprenoids with a C₂₀ skeleton are known as diterpenoids and are derived from the common precursor, geranylgeranyl diphosphate (GGPP). This dissertation describes approaches to discover the diterpene synthase enzymes which provide the backbone structures for pleuromutilin and...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: __________________________________________ Philip J. Proteau The isoprenoid

  • Studies toward the synthesis of coibamide A and analogues

    Creator:
    Li, Dong
    Abstract:
    Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian marine filamentous cyanobacteria as part of an International Cooperative Biodiversity Groups (ICBG) program based in Panama. This structurally unique agent exhibits potent cancer cell toxicity with an unprecedented selectivity profile in the National Cancer Institute (NCI) 60 cell line...
    Resource Type:
    Dissertation
    Full Text:
    : Philip J. Proteau Coibamide A is a highly methylated cyclic depsipeptide isolated from Panamanian

  • Time Periodic Sand Ripples at the Oregon Coast

    Creator:
    Korn, Abraham
    Abstract:
    We consider development of sand ripples in shallow water flows which do not reach an equilibrium height but have a time-varying ripple height that slowly reaches a maximum value and then is quickly destroyed by the fluid. A simple scenario to explain the time periodic behavior of the sand ripples...
    Resource Type:
    Honors College Thesis
    Full Text:
    Oregon Coast Abstract approved: Dr. Philip J. Siemens We consider development of sand ripples in

  • Sex role discrimination and preference in preschool aged children

    Creator:
    Sugawara, Alan Iwao, 1939-
    Abstract:
    The two major purposes of this study were: (1) to test the assumption that the IT Scale for Children (standard-ITSC) can be used as a measure of both appropriate sex role discrimination and sex role preference with preschool aged children, and (2) to extend previous studies in these areas by...
    Resource Type:
    Dissertation
    Full Text:
    in elude: My committee who guided me through this doctoral program: Dr. J. Philip O'Neill, Head

  • Pion content in nucleon using finite renormalization scheme with spectral amplitude separation of ghosts

    Creator:
    Symmes, Jonathan P.
    Abstract:
    We develop a technique to express the nucleon pole strength and bare mass in terms of renormalized quantities. Starting from a general unrenormalized self energy we determine the bare mass and the pole strength. For determining the pion content of the nucleon we discuss the leading renormalization loop. We relate...
    Resource Type:
    Dissertation
    Full Text:
    approved: Philip J. Siemens We develop a technique to express the nucleon pole strength and bare mass in

  • A geographic application project utilizing location-allocation computer programs to determine canning facility locations in the Willamette Valley

    Creator:
    Maddocks, Nicholas Anthony
    Abstract:
    A Willamette Valley farm cooperative was interested in evaluating locations for their canning facilities based on the criterion of minimizing aggregate distance to their contract farms. This location problem presented an excellent opportunity for a geographic application project as it was characterized by one, a spatial distribution of farms and...
    Resource Type:
    Capstone Project
    Full Text:
    requirements for the degree of MASTER OF SCIENCE March 1981 Directed by Dr. Philip L. Jackson TABLE OF