Index Catalog // ScholarsArchive@OSU

Development and broad application of a mass spectrometry based metabolomics platform

Creator:: Kirkwood, Jay Steven
Abstract:: Metabolomics is a comprehensive analysis of small molecules, or metabolites, in a system. Metabolomics is a hypothesis-generating experiment and offers an unbiased analysis of cell metabolism that can aid in the understanding of fundamental biological processes. Metabolomics is widely and broadly applicable in the biological sciences and has been used...
Resource Type:: Dissertation
Full Text:: chromatography-quadrupole-time-of-flight mass spectrometry metabolomics platform and details the various steps

The identification and quantitation of complex polycyclic aromatic hydrocarbon mixtures in environmental samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry

Creator:: Manzano, Carlos A.
Abstract:: Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants and are mostly products of the incomplete combustion of organic material. PAHs are often found in environmental samples as a complex mixture of isomers. In addition, the same sources that produce complex PAH mixtures also produce other poorly characterized mixtures of organic compounds,...
Resource Type:: Dissertation
Full Text:: Chromatography with Time-of-flight Mass Spectrometry Abstract approved: Staci L. Massey Simonich

Surface composition and orientation of room temperature ionic liquids

Creator:: Law, George
Abstract:: In this thesis, we investigated the surface composition and orientation of both pure room-temperature ionic liquids (Ils) and binary mixtures of the ILs of the type consisting of the 1-alkyl-3-methylimidazolium ([C[subscropt n]mim]⁺, n=4, 8, and 12) cation coupled with either [PF₆]⁻, [BF₄]⁻, [Cl]⁻, or [Br]⁻. The surfaces of the ILs...
Resource Type:: Dissertation
Full Text:: and recoiling spectrometry (TOF-SARS), and time-of-flight direct recoil spectrometry (TOF-DRS). The

Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater

Creator:: Chiaia Hernandez, Aurea C.
Abstract:: A sensitive, selective, rapid analytical method based on large-volume injection (LVI) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware that eliminates the need for either off-line or on-line solid phase extraction. Centrifugation followed by the direct injection of 1,800 µL was used for the quantification of illicit drugs,...
Resource Type:: Masters Thesis
Full Text:: ) liquid chromatography/ tandem mass spectrometry was developed using commercially-available hardware

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: memory. Firstly, we explored the applicability of travelling wave ion mobility mass spectrometry

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Creator:: Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
Abstract:: Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Resource Type:: Article

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: commonly used mass analyzers in this field include the quadrupole (Q), ion trap (IT), time-of-flight (TOF

Gas-phase fragmentation chemistry of protonated peptide ions

Creator:: Bythell, Benjamin James
Abstract:: The fragmentation characteristics of protonated peptides have been investigated using tandem mass spectrometry (MS/MS) under various fragmentation regimes and detailed density functional theory (DFT) reaction pathway calculations. The DFT calculations predict novel salt-bridge stabilized transition structures as well as consecutive reactions occurring in proton-bound dimers for some of the ions...
Resource Type:: Dissertation
Full Text:: …………………..............………....... 7 1.2.3.3 Time-of-flight Mass Spectrometry ………………….................... 8 1.2.3.3.1 MALDI

Spatiotemporal Phytohormone Distributions in Developing Pinot Noir Berries and the Effects of Two Viticulture Practices Thereon

Creator:: Schmidt, Joseph A.
Abstract:: In recent years, many studies have focused on the molecular and biochemical mechanisms regulating the development of wine grapes. The course of grape berry development is directed by genetic design and is mediated by phytohormones, which regulate grape berry growth and development by orchestrating a complex network of interacting genes,...
Resource Type:: Masters Thesis
Full Text:: . Liquid chromatography coupled to tandem mass spectrometry was then used to analyze the extracted

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: exchange mass spectrometry (HDX MS) technology for studying the conformational dynamics of large multi

ScholarsArchive@OSU

Development and broad application of a mass spectrometry based metabolomics platform

The identification and quantitation of complex polycyclic aromatic hydrocarbon mixtures in environmental samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry

Surface composition and orientation of room temperature ionic liquids

Large volume (1,800 µL) injection HPLC/MS/MS for the quantitative determination of illicit drugs and human urinary biomarkers in municipal wastewater

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Human in vivo Pharmacokinetics of [¹⁴C]Dibenzo[def,p]chrysene by Accelerator Mass Spectrometry Following Oral Micro-Dosing

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Gas-phase fragmentation chemistry of protonated peptide ions

Spatiotemporal Phytohormone Distributions in Developing Pinot Noir Berries and the Effects of Two Viticulture Practices Thereon

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

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