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Filtering by: Creator Maestas, J. D. Remove constraint Creator: Maestas, J. D. Rights Statement In Copyright - Educational Use Permitted Remove constraint Rights Statement: In Copyright - Educational Use Permitted

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  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    ) Newman, D. J.; Cragg, G. M.; Snader, K. M. Nat. Prod. Rep. 2000, 17, 215-234. (2) Dias, D. A.; Urban

  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
    Resource Type:
    Dissertation
    Full Text:
    ......................................... 69 3.2 Structural features of C-24 alkyl derivatives that enhance gene transfection. (a-d) C-24

  • Just a tool after all? No evidence for tool-use effects on the body representation across virtual and real environments

    Creator:
    Bell, Joshua D.
    Abstract:
    While human tool-use proficiency helped define our history, the cognitive and perceptual mechanics of how humans use tools are not fully understood. This question is of great value to the design of hand-held tools and prosthetics. A prominent theory, tool embodiment, suggests that tool use is facilitated by a flexible...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Joshua D

  • Applied economic strategies to evaluate policies and environmental outcomes: case studies from immigration and ecosystem services

    Creator:
    Natanson, Alexander D.
    Abstract:
    My dissertation title is, “Applied economic strategies to evaluate policies and environmental outcomes: case studies from immigration and ecosystem services.” The first two chapters of this dissertation concern the relationship between local immigration policies and societal welfare. The third chapter examines the impact of human activity on the environment and...
    Resource Type:
    Dissertation

  • Swells, soundings, and sustainability, but... here be monsters

    Creator:
    Wright, Dawn J.
    Abstract:
    The Roger Revelle Commemorative Lecture Series was created by the Ocean Studies Board of the National Academies in honor of Roger Revelle to highlight the important links between ocean sciences and public policy. Dawn J. Wright, the eighteenth annual lecturer, spoke on April 28, 2017, at the Smithsonian National Museum...
    Resource Type:
    Article
    Full Text:
    . Craig, T.E. Essington, D. Fluharty, J. Rice, and J.N. Sanchirico. 2013. Marine spatial planning in

  • Monotonic and Cyclic Testing of Cross-Laminated Timber Diaphragms

    Creator:
    Beairsto, Cody J.
    Abstract:
    Mass timber is emerging as a viable form of construction around the world in new markets for wood buildings. The entrance into these markets has driven the demand for more knowledge to enable designs alongside other structural materials such as steel and reinforced concrete. Large, in-plane tests on cross-laminated timber...
    Resource Type:
    Masters Thesis

  • A three-dimensional mapping of the ocean based on environmental data

    Creator:
    Wright, Dawn J.
    Abstract:
    The existence, sources, distribution, circulation, and physicochemical nature of macroscale oceanic water bodies have long been a focus of oceanographic inquiry. Building on that work, this paper describes an objectively derived and globally comprehensive set of 37 distinct volumetric region units, called ecological marine units (EMUs). They are constructed on...
    Resource Type:
    Article
    Full Text:
    mapping of the ocean based on environmental data 2 Author List: 3 Roger G. Sayre1, Dawn J. Wright2

  • Knowledge Appropriation and Inventive Productivity

    Creator:
    Choi, Yohan
    Abstract:
    Innovation is critical for firm growth and survival. Thus, how much value firms create and capture from their innovative activities has been an interest of scholars. This dissertation explores three important questions on this topic to which extant literature has paid little attention. First, I examine how the external threat...
    Resource Type:
    Dissertation
    Full Text:
    firm financial returns to R&D activities and that this effect is contingent upon concurrent use of

  • Application of Infrared Spectroscopy for Determination of Wood Natural Durability

    Creator:
    Lipeh, Shahlinney
    Abstract:
    Natural durability remains one of the most attractive characteristics of wood, and helps wood obtain a premium price. A worldwide shift towards the use of younger trees from intensively managed forests has created greater concerns about wood quality, especially the wood’s resistance to fungi and insects. Wood durability is assessed...
    Resource Type:
    Dissertation
    Full Text:
    : ______________________________________________________________________ Jeffrey J. Morrell Natural durability remains one of the most attractive characteristics of

  • Efficacy of Empirical Seed Zones: Pseudoroegneria Spicata Reproductive Phenology & Seedling Stage Traits

    Creator:
    Prive, Kathryn A.
    Abstract:
    Ecological restoration is needed to mitigate losses to biodiversity. Restoration success is enhanced through the use of native plant materials that are genetically diverse and locally adapted. Seed transfer zones have been developed to delineate geographic areas where native seed can be collected and distributed with reduced risk of maladaptation....
    Resource Type:
    Masters Thesis
    Full Text:
    ., Lowe, A., Coates, D. J., Cunningham, S. A., McDonald, M., Vesk, P. A., & Yates, C. (2008). Seed