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Selenium and Selenoprotein Deficiencies Induce Widespread Pyogranuloma Formation in Mice, while High Levels of Dietary Selenium Decrease Liver Tumor Size Driven by TGFα

Creator:

Moustafa, Mohamed E., Carlson, Bradley A., Anver, Miriam R., Bobe, Gerd, Zhong, Nianxin, Ward, Jerrold M., Perella, Christine M., Hoffmann, Victoria J., Rogers, Keith, Combs, Gerald F., Jr., Schweizer, Ulrich, Merlino, Glenn, Gladyshev, Vadim N., and Hatfield, Dolph L.

Abstract:

Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a controlled hepatocarcinogenesis study involving varying levels of dietary selenium and altered selenoprotein status using...

Resource Type:

Article

Full Text:

Tumor Size Driven by TGFa Mohamed E. Moustafa1.¤a, Bradley A. Carlson1., Miriam R. Anver2., Gerd Bobe3