Index Catalog // ScholarsArchive@OSU

Creator:: Schoenhard, Grant Louis
Abstract:: Aflatoxins B₁, Q₁ and aflatoxicol, R [subscript o] F, but not B₂ were activated in the presence of NADPH by the 105,000 x g pellet from rainbow trout (Salmo gairdneri), Mt. Shasta strain, liver to products lethal to Bacillus subtilis GSY 1057 (metB4, hisAl, uvr-1). Electron microscopy confirmed the microsomal...
Resource Type:: Dissertation
Full Text:: of NADPH by the 105, 000 x g pellet from rainbow trout (Salmo gairdner-i), Mt, Shasta strain

Creator:: Liang, Xiaoshan
Abstract:: Characterization of the 5' flanking region of rainbow trout ki-ras gene was begun with the cloning and sequencing of this region by the inverse PCR technique and dideoxynucleotide chain termination method. In total, a nucleotide sequence of 1080 bp upstream from the first coding ATG was sequenced. Although this region...
Resource Type:: Dissertation
Full Text:: of codon 12 had differential affinity to AFB I, the more 5' G was relatively inaccessible but the

Creator:: Valsta, Liisa M.
Abstract:: In rodent models as well as in fish models there are significant species differences in the susceptibility toward aflatoxin B₁ (AFB₁) carcinogenesis. Mouse is less susceptible toward AFB₁ carcinogenesis than rat. Researchers have come to the conclusion that the lower susceptibility of mice is not a result of less effective...
Resource Type:: Masters Thesis
Full Text:: lipophillc metabolites AFQ|, AFMj, AFPj, and AFL (pmol/g protein) separated by HPLC 74 10. The percentage

Creator:: Whitham, Mark
Abstract:: Aflatoxin B₁ (AFB₁,) is a potent liver carcinogen to a number of animal species including rainbow trout (Salmo gairdneri). Microsomal activation is required for the in vitro conversion of AFB, to a reactive metabolite, thought to be the AFB₁,-2,3-oxide, which will bind nucleic acids, produce toxicity, and cause mutagenesis. Nucleic...
Resource Type:: Masters Thesis
Full Text:: acid binding exceeded that to protein 4 to 33-fold on a per milligram basis (Garner, 1975a; Swenson

Creator:: Moyer, Richard A.
Abstract:: The question of how the presence of nucleosomal packing of DNA modifies carcinogen interaction at specific sites cannot be answered by studies on whole chromatin or bulk nucleosomes because of the heterogeneity of DNA sequences in the particles. This problem was circumvented by constructing nucleosomes that are homogenous in DNA-histone...
Resource Type:: Dissertation
Full Text:: . MONONUCLEOSOME PREPARATION 24 E. PLASMID PREPARATION 25 F. PREPARATION OF END LABELED 5S DNA FRAGMENTS 28 G

Creator:: Troxel, Claudia McLaughlin
Resource Type:: Dissertation
Full Text:: Toxicology Pro Dean of G to School I understand that my thesis will become part of the permanent collection

Creator:: Núñez, Oliva
Resource Type:: Masters Thesis
Full Text:: were given [Ii]-thymidine ([1H]-TdR) i.p. at a single dose of 5 11Ci/g body weight at 0, 1, 3, 7, and

Creator:: Goeger, Douglas Eugene
Abstract:: Indole-3-carbinol (I3C) and butylated hydroxyanisole (BHA), anti-carcinogens present in the human diet, were tested for their in vivo and in vitro effect on aflatoxin B₁. (AFB₁) metabolism, and DNA adduct formation in the rainbow trout. Dietary BHA at either 0.3 or 0.03% had no effect on the hepatic tumor incidence...
Resource Type:: Dissertation
Full Text:: various times after AFB. exposure ..... 56 III-2. AFB1 and metabolites in the 100,000 x g super

Creator:: You, Lijing
Abstract:: Previous reports indicate the presence of multiple CYP1A sequences in rainbow trout, but their functional differences are unknown. This report describes the cloning and partial characterization of four trout CYP1A cDNAs, which are given the tentative designations CYP1A1v2, v3, v4, and v5. Comparison among these four and three previously reported...
Resource Type:: Masters Thesis
Full Text:: thaw during centrifugation at 14,000 g for 5 min to remove the precipitated proteins. Metabolites

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