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Filtering by: Subject Antibacterial agents -- Structure-activity relationships

A quantitative structure activity relationships study of antiinfectives based on the nalidixic acid structure

Creator:

Yu, Yupei

Abstract:

Nalidixic acid and its derivatives act through inhibition of bacterial DNA gyrase activity. Recently there have been a series of papers reporting the antibacterial activity against three different types of bacteria (S. aureus, E. coli and P. aeruginosa) by a series of 1,4-dihydro-4-oxoquinoline (or 1,8-naphthyridine) 3-carboxylic acids. Consistent biological data...

Resource Type:

Masters Thesis