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Filtering by: Subject Antibiotics -- Toxicity testing

Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

Creator:

Kaller, Margo

Abstract:

Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...

Resource Type:

Masters Thesis