Avermectins are a group of potent anthelmintic agents produced by Streptomyces avermitilis. They are active at extremely low dosages and are now in commercial use. In this study, the synthesis of two segments of avermectin B[subscript 1a] are described. The synthesis of the hexahydrobenzofuran subunit (segment A) began with the...
Avermectin Bia is a member of a class of medicinally important
natural products known for its potent antiparasitic activity and
interesting structural features. In this thesis, synthesis of a
model for the spiroketal portion of the avermectins is presented.
Oxidation of (S)-2-methylbutanol, followed by a stereoselective
chromium mediated reaction with...