Index Catalog // ScholarsArchive@OSU

Genotypic and phenotypic characterization of enterotoxigenic Clostridium perfringens type A fecal isolates associated with human gastrointestinal diseases in the United Kingdom

Creator:: Harrison, Ben
Abstract:: Clostridium perfringens type A isolates producing enterotoxin (CPE) are an important cause of food poisoning and non-food-borne human gastrointestinal (GI) diseases, including antibiotic-associated diarrhea (AAD), and spontaneous diarrhea (SD). In enterotoxigenic type A isolates, the cpe gene is found on the chromosome in food poisoning isolates, but is present on...
Resource Type:: Masters Thesis

Genomics-enabled exploration of insect toxicity in the Pseudomonas fluorescens group

Creator:: Rangel, Lorena I.
Abstract:: Pseudomonas is a diverse genus of Gamma proteobacteria that are ubiquitous in the natural environment, including soil, water, plant surfaces, and animals. The Pseudomonas fluorescens group is a diverse collection of seven subgroups and more than 50 named species. This group is known for their production of a variety of...
Resource Type:: Masters Thesis

Quorum sensing gene regulation in Pseudomonas aeruginosa

Creator:: Gupta, Rashmi
Abstract:: Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
Resource Type:: Dissertation

Characterization of the interaction between Mycobacterium avium subsp. paratuberculosis and bovine epithelial cells in culture and identification of invasion-associated genes by transposon mutagenesis

Creator:: Patel, Dilip
Abstract:: Mycobacterium avium subsp. paratuberculosis (MAP) is a cause of Johne's disease (JD) in cattle and other ruminants. MAP infection in the bovine host is not well characterized. It is assumed that crossing the bovine intestinal mucosa is important for MAP to establish infection. MAP's ability to infect bovine epithelial cells...
Resource Type:: Dissertation

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Creator:: Quinn, Matthew J.
Abstract:: The pathogen Vibrio cholerae uses cations as a primary currency of virulence and environmental persistence, using gradients of those cations to move, acquire nutrients, and control virulence gene expression. An understanding of the overlapping roles of bioenergetics and chemotaxis in the virulence and environmental survival of V. cholerae issues from...
Resource Type:: Dissertation

Recombination, resistance, and drug discovery in Chlamydia

Creator:: Sandoz, Kelsi
Abstract:: The intracellular life cycle of Chlamydia has been difficult to study due to the inability to genetically manipulate the bacteria. As a result, indirect methods have been employed to study the pathogen and the aspects that contribute to its unique intracellular life cycle. A wide variety of laboratory adapted strains,...
Resource Type:: Dissertation

Evolution of a streamlined cooperator in Pseudomonas aeruginosa quorum sensing

Creator:: Huie, Jessica L.
Abstract:: Social behavior leading to the production of common goods is prone to exploitation. One such behavior in Pseudomonas aeruginosa is quorum sensing (QS), by which the bacteria produce signals to regulate extracellular common goods. Exploitation comes in the form of cheaters which have a mutation in the central quorum sensing...
Resource Type:: Masters Thesis

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Creator:: Jha, Samradhni
Abstract:: Mycobacterium avium is a ubiquitous environmental organism found in water and soil. It can cause disease in patients with pre-existing pulmonary conditions, immunocompromised patients with the most prevalent being AIDS patients, as well as apparently healthy people. Studies have indicated that, upon macrophage uptake, Al. avium prevents phagosome-lysosome fusion, thus...
Resource Type:: Masters Thesis

Understanding chlamydial biology through genome sequencing and comparative genomics

Creator:: Jeffrey, Brendan
Abstract:: The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
Resource Type:: Dissertation

Development and application of genomic DNA based methods for the identification and characterization of marine bacterioplankton

Creator:: Lanoil, Brian D.
Abstract:: A series of experiments was performed to determine the feasibility of genomic DNA-based methods for ecological and physiological studies of dominant bacteria from complex natural systems. Two approaches, bacterial chromosomal painting (BCP) and environmental genomics (EG), were evaluated for the potential to identify and enumerate specific bacterial groups in situ...
Resource Type:: Dissertation

ScholarsArchive@OSU

Genotypic and phenotypic characterization of enterotoxigenic Clostridium perfringens type A fecal isolates associated with human gastrointestinal diseases in the United Kingdom

Genomics-enabled exploration of insect toxicity in the Pseudomonas fluorescens group

Quorum sensing gene regulation in Pseudomonas aeruginosa

Characterization of the interaction between Mycobacterium avium subsp. paratuberculosis and bovine epithelial cells in culture and identification of invasion-associated genes by transposon mutagenesis

Molecular and genetic assessment of selected antiporters and methyl-accepting chemotaxis proteins in Vibrio cholerae

Recombination, resistance, and drug discovery in Chlamydia

Evolution of a streamlined cooperator in Pseudomonas aeruginosa quorum sensing

Macrophage infection with wild-type Mycobacterium avium or isogenic attenuated PPE mutant revealed differences in gene expression and mycobacterial vacuole proteins

Understanding chlamydial biology through genome sequencing and comparative genomics

Development and application of genomic DNA based methods for the identification and characterization of marine bacterioplankton

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