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Filtering by: Creator Larsson, Lena C. Remove constraint Creator: Larsson, Lena C. Subject Bacteriophage T4 Remove constraint Subject: Bacteriophage T4

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Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:

Ji, Jiuping

Abstract:

A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...

Resource Type:

Dissertation

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temperature (34° C). Sequence analysis of revertants from the most sensitive gene marker, rII SN103, showed
Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:

Sargent, Roy Geoffrey

Abstract:

Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...

Resource Type:

Dissertation

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B. T4 Deoxyribonucleotide Metabolism 6 C. T4 DNA Replication 17 D. T4 DNA Repair 22 E
Attempted cloning of T4 phage ribonucleotide reductase

Creator:

Booth, Joseph

Abstract:

Ribonucleotide reductase is an important enzyme in the control of DNA replication within the cell. Ribonucleotide reductase exerts its control through enzymatic reduction of nucleoside diphosphates. The bacteriophage T4 enzyme is an example of the class of iron-requiring reductases which also includes E. coli and mammalian ribonucleotide reductases. The two...

Resource Type:

Masters Thesis

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Bacteriophage T4 RDPR 5 c. The mammalian RDPR 6 2. B12-requiring RDPR enzymes 7 3. Manganese-requiring RDPR
Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:

Ungermann, Christian

Resource Type:

Masters Thesis

Full Text:

the Bacteriophaoe T4-coded dCTPase- dUTPase Abstract approved: C ristopher K. Mathews, Ph.D. The
Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:

Hanson, Eric Scott

Resource Type:

Dissertation

Full Text:

1.7. Allosteric regulation of the T4 RNR 26 2.1. Region alignment of T4 and C. moewussi sequences that

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Academic Affiliation

Biochemistry and Biophysics4

Advisor

Mathews, Christopher K.5

Commencement Year

Commencement Year range begin – Commencement Year range end

Current results range from 1987 to 1995

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Committee Member

Barofsky, Douglas1
Bayne, Christopher J.1
Hays, J.1
Ho, Shing1
Leong, Jo-Ann1
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Creator

Booth, Joseph1
Hanson, Eric Scott1
Ji, Jiuping1
Sargent, Roy Geoffrey1
Ungermann, Christian1

Date

Date range begin – Date range end

Current results range from 1987 to 1994

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Decade

1990-19993
1980-19892

Degree Field

Biochemistry and Biophysics4
Genetics1

Degree Level

Doctoral3
Master's2

Degree Name

Doctor of Philosophy (Ph.D.)3
Master of Science (M.S.)2

Language

English [eng]5

Non-Academic Affiliation

Oregon State University. Graduate School5

Peer Reviewed

No5

Resource Type

Dissertation3
Masters Thesis2

Rights Statement

Copyright Not Evaluated5

Subject

Bacteriophage T4[remove]5
DNA -- Synthesis4
Escherichia coli -- Genetics2
Bacteriophages -- Genetics1
DNA damage1
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