Ion therapy has long been investigated as a potential modality to improve cancer treatments beyond what is currently feasible with photon irradiations. Ions offer both a physical and biological advantage over photons. The physical advantages are well understood, ions deposit their maximum dose at defined penetration depths, allowing for minimal...
Conclusion: The first part of this note deals with problems of propagation of error and the latter part with questions commonly identified as "model validation" questions. It is concluded that all validation questions can be resolved into two parts: (1) strategic aspects, involving logical and inferential structures and (2) tactical...