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  • Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

    Creator:
    Goodale, Britton C.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
    Resource Type:
    Dissertation
    Full Text:
    Developmental Toxicity of Polycyclic Aromatic Hydrocarbons

  • Consequences of miRNA misregulation on embryonic development and aging

    Creator:
    Franzosa, Jill A.
    Abstract:
    microRNAs (miRNAs), ~21-24 nucleotide-long RNAs that post-transcriptionally regulate gene expression, have rapidly become one of the most extensively studied mechanisms of the past decade. Since their discovery as temporal regulators of post-embryonic development in C. elegans, miRNAs have been functionally implicated in almost every cellular process investigated to date. miRNAs...
    Resource Type:
    Dissertation
    Full Text:
    developmental stages. First, to uncover the potential role of miRNAs in teratogenicity, we investigated