The fate of hexachlorophene, a widely used bactericide, was
investigated using both intact male rats and rabbits and liver microsomes
from male rats. Hexachlorophene administered intraperitoneally
was found to be rapidly absorbed and distributed to all the
tissues of the animals. Excretion of the chemical in both species
occurred slowly,...
Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol))
was developed as an antibacterial agent but was also found to induce
toxic effects in various tissues in animals and humans. Changes were
found in myelinated nerve fibers and cerebral white matter. Erythrocytes
are hemolysed in vitro. Oxidative phosphorylation is uncoupled
by HCP at concentrations less than...
Low concentrations of hexachlorophene (HCP) inhibit a number of pyridine nucleotide-linked dehydrogenase enzymes. The I₅₀ HCP concentrations were 105 μM for pig heart isocitrate dehydrogenase (ICD), 65 μM for horse liver alcohol dehydrogenase, 39 μM for torula yeast glucose-6-phosphate dehydrogenase (G6PD), 6.0 μM for beef heart malate dehydrogenase, and 1.6...