The presence in rat liver microsomes of an enzyme system
which demethylates N-methylhydrazines and azo compounds to formaldehyde
has been reported. Some of the compounds found to be
substrates were monomethylhydrazine, N-isopropyl-α-(2-methylhydrazino)-
p-toluamide and the azo derivative of the latter hydrazine. This
enzyme can be classified as a mixed function...
An aspect of the metabolism of monoalkylhydrazines has been
investigated using both intact rats and rat liver microsomal enzyme
preparations.
Intact rats respired propane and n-butane on administration of 0.3-0.5 mmoles of isopropyl- and n-butylhydrazine, respectively.
Based upon dose administered, a five to ten percent
yield of hydrocarbon was obtained....