Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Gharib, Camron I. Subject Lipoic acid -- Physiological effect

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:

Smith, Anthony R.

Abstract:

The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...

Resource Type:

Dissertation

Full Text:

Chair of the Molecular and Cellular Biology Program Dean of the Graduate School I understand that my
Antioxidant mechanisms of ascorbate and (R)-α-lipoic acid in aging and transition metal ion-mediated oxidative stress

Creator:

Shu, Jung Hyuk

Abstract:

Oxidative stress is the major driving force behind the aging process and many age-related diseases. However, direct experimental evidence of whether antioxidants, such as ascorbate (AA) and lipoic acid (LA) can slow the progression of aging process and/or reduce risks of developing degenerative disease is largely absent. This suggests a...

Resource Type:

Dissertation

Full Text:

AN ABSTRACT OF THE DISSERTATION OF Jung I-Iyuk Suh for the