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Filtering by: Committee Member Zabriskie, Mark T. Remove constraint Committee Member: Zabriskie, Mark T. Subject Marine natural products Remove constraint Subject: Marine natural products

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  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    also wish to thank Dr. Mark Zabriskie and Dr. Taifo Mahmud for their advice and support, as well as

  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    my very great appreciation to Dr. Mark Zabriskie for your kindness, support and advice throughout

  • Biologically active cyclic depsipeptides from marine cyanobacteria

    Creator:
    Medina, Rebecca A.
    Abstract:
    This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites. A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
    Resource Type:
    Dissertation
    Full Text:
    . Mark Zabriskie, Dr. Max Deinzer, Dr. Gary DeLander, Dr. Bruce Coblentz and Dr. Doug Markle for their