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Filtering by: Subject Zebra danios as laboratory animals Subject Toxicity testing -- In vivo

Classifying Chemical Bioactivity by Coupling High-throughput Phenotypic Anchoring and Transcriptome Profiling in Zebrafish

Creator:

Haggard, Derik

Abstract:

There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...

Resource Type:

Dissertation

Full Text:

, decreased the expression of many Hox genes as well as enzymes responsible for retinoic acid metabolism
Embryonic and Larval Zebrafish Bioassays for Biomedical Research : The Larval Photomotor Response Screening Assay and Phenotype

Creator:

Fisher, Joseph A.

Abstract:

Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...

Resource Type:

Dissertation

Full Text:

biocompatibility of thousands of substances or compounds. The zebrafish (Danio rerio) is now recognized as an