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Filtering by: Creator L’Heureux, K. Remove constraint Creator: L’Heureux, K. Subject Vaccinia Remove constraint Subject: Vaccinia

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  • Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

    Creator:
    Spiro, Craig
    Abstract:
    Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
    Resource Type:
    Dissertation
    Full Text:
    Metabolism in Vaccinia Virus-Infected Mammalian Cells. Abstract Redacted for Privacyapproved: Christopher K

  • Fatty acylation of Vaccinia virus proteins : dual myristylation and palmitylation of the A-type inclusion protein

    Creator:
    Martin, Karen H.
    Abstract:
    The attachment of myristic acid to the N-terminal glycine residue of many eukaryotic and viral proteins is often essential for the acquisition of the protein's biological activity. Vaccinia virus (VV), the prototype member of the Poxviridae, expresses several myristylated proteins during the course of infection. Only one of these proteins,...
    Resource Type:
    Dissertation
    Full Text:
    insufficient to anchor the protein in the membrane (Silvius and L'Heureux, 1994). The farnesyl group may

  • Identification and analysis of vaccinia virus acylproteins

    Creator:
    Hansen, Scott G.
    Abstract:
    Vaccinia virus (VV) encodes at least six proteins that are modified by the addition of a 14-carbon saturated fatty acid through an amide linkage and at least eight proteins that are modified post-translationally by the addition of a 16-carbon saturated fatty acid through linkage to cysteine residues. These post-translational modifications...
    Resource Type:
    Dissertation
    Full Text:
    Mutants ............................................... 109 4.2.6 Proteinase K Treatment