North American bighorn sheep (Ovis canadensis) have experienced significant declines and population extirpations due to novel pathogens such as Mycoplasma ovipneumoniae. This disease continues to limit the population restoration of bighorn sheep. Therefore, understanding the demographic consequences of pathogen presence and the risk of contact between bighorn populations and potential...
Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
The purpose of this study was to understand the vulnerability and adaptive capacity of shellfish stakeholders in the Pacific Northwest who are adapting to ocean acidification (OA). This study developed a geovisualization tool of existing environmental data for assessing species-specific risk profiles to OA (based on their exposure and sensitivity),...
The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
The fungus Nothophaeocryptopus gaeumannii is the causative agent of Swiss needle cast (SNC), a foliar disease of Douglas-fir. Disease is characterized by premature loss of foliage and reduced growth resulting from the inhibition of photosynthesis due to the occlusion of stomata by the ascocarps of N. gaeumannii. Although the disease...
Gall-associated phytopathogens have unique evolutionary histories that haveshaped both their modes of infection and genomic structures. Pathogenicity of the gall-associated plant pathogens of the Rhodococcus, Agrobacterium, and Rathayibactergenera is mediated by horizontally acquired virulence loci. The relative ease of gainand loss of the virulence loci has confounded accurate characterization of...
Exposure to urban outdoor air pollution is ubiquitous and low birth weight represents an important health disparity in the United States. While previous research suggests that exposure to outdoor air pollutants are associated with term low birth weight, few studies have evaluated the effects of multipollutant outdoor air exposures or...
This research work investigates the use of production
systems as a model of parallel processing. The purpose of
the model is to provide a suitable medium within which parallel
processing systems can be systematically specified,
analyzed, and designed. Furthermore, the model provides a
suitable means for deriving implementations of synchronization...