Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
, Atsushi Nakagawa, Haruki
Nakamura, AnthonyNicholls, Marc Nicklaus, Robert T. Nolte, Anil K.
Padyana
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
Nakamura,28 AnthonyNicholls,15
Marc Nicklaus,29 Robert T. Nolte,30 Anil K. Padyana,31 Catherine E
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Subduction zone recycling of volatiles (H₂O, Cl, S, F) is controlled by the nature of subducted materials and the temperature-pressure profile of the downgoing slab. We investigate the variability in volatile and fluid-mobile trace element enrichment in the Sunda arc using melt inclusion data from Kawah Ijen and Tambora volcanoes,...
Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
The well-known fact that tropical sea level can be usefully simulated by linear wind driven models recommends it as a realistic test problem for data assimilation schemes. Here we report on an assimilation of monthly data for the period 1975-1992 from 34 tropical Pacific tide gauges into such a model...
St. Joseph's College was located within St. Paul, Oregon, the first Roman Catholic mission in the Pacific Northwest. The St. Paul mission was finally established in 1839 by Father Francois Blanchet, four years after the French-Canadian settlers in the area, appropriately known as French Prairie, had requested the presence of...
Nearly all birds communicate through sound, and there has been much study of avian populations and communities using song and other vocalizations. Owls are no exception as they defend territories, advertise for mates, and defend against threats using various vocalizations. However, due to their generally nocturnal habits, some owl species...
I used a comparative and experimental approach to examine nest habitat selection, reproductive success, and nest site fidelity of burrowing owls (Athene cunicularia) in a large, non-fragmented grassland in southwest California. In 1999, I compared habitat characteristics between nest sites (n = 31) and randomly selected, unoccupied burrows (n =...
Policy and research have increased attention in K12 mathematics education on core mathematical practices such as argumentation, justification, and proof, that are central to students learning and doing mathematics. One reason for this increased focus is the empirical evidence that engaging students in mathematical practices provide more equitable opportunities for...