Recently, we demonstrated that a radio-frequency-free electromagnetostatic (RF-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell [1-2]. Subsequently, we used our RF-free EMS cell in the same instrument platform...
Recently, we demonstrated that a radio-frequency-free electromagnetostatic (RF-free EMS) cell could be retrofitted into a triple quad mass spectrometer to allow electron-capture dissociation (ECD) without the aid of cooling gas or phase-specific electron injection into the cell [1-2]. Subsequently, we used our RF-free EMS cell in the same instrument platform...
This thesis describes the chemical investigation of marine cyanobacteria collected in Madagascar and Panama with an emphasis on the isolation and structure elucidation of medicinally relevant secondary metabolites.
A collection of the marine cyanobacterium Lyngbya majuscula from the Radames Islands, Madagascar yielded two new cyclic depsipeptides, radamamides A and B,...
The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
The rhenium (V) complex Tp'ReO₂ (Tp' = hydrido-tris-(3,5-
dimethylpyrazolyl)borate), generated in situ from PPh₃ reduction of
Tp'Re0₃, reacts with small ring heterocycles such as epoxides and
episulf ides. The strained trans-cyclooctene ring provides an unusual
thermodynamic bias against direct atom transfer, but trans-cyclooctene
oxide still produces substantial amounts of trans-cyclooctene....
'Gala' is an apple cultivar with a distinctive aroma and flavor. 'Gala' storage season is short in regular atmosphere (RA). Controlled atmosphere (CA) extends 'Gala' storage but volatile production is reduced. 'Gala' odor-active aroma compounds were identified using Osme, a gas chromatography and olfactometry technique. Changes in aroma after RA...
In wood-plastic composites (WPCs) a compatibilizer is often used to improve
the interfacial adhesion between the hydrophilic wood filler and the hydrophobic
plastic matrix. At present, while the basic concepts of compatibilization are
understood, the optimized chemical structures of an effective compatibilizer, including
the ideal structures of the wood-binding domain...
Traditional readings of George Bernard Shaw's texts suggest that he is not a pure
Marxist socialist because of the spiritual and nationalist aspects of his vision. This thesis
attempts to confront Shaw's politics in order to demonstrate that he indeed offers a viable
socialist program. Overlaying his socialism with Louis...
Part 1:
White muscle disease (WMD), a degenerative muscle disease brought on by a deficiency of the essential trace nutrient selenium, is thought to be mediated by the protein Selenoprotein W (SeW). In its relationship with WMD, SeW, like many selenoproteins, binds to glutathione, serving some purpose in redox mechanisms...