Index Catalog // ScholarsArchive@OSU

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

Creator:: Hoyt, Dale G.
Abstract:: Previous investigation showed that 20 mg/kg BCNU caused inhibition of sulfobromophthalein (BSP) excretion and inhibited bile salt independent bile flow (BSIF) in rats by 48 h after treatment (Hoyt, 1984). The present investigation demonstrated that BCNU inhibited the canalicular step in the excretion of BSP. This was indicated by the...
Resource Type:: Dissertation
Full Text:: (carmustine or BCNU) in Rats Abstract approved: Redacted for Privacy 1 Robert E. Larson Previous

The effect of hypothermia on biochemical and morphological aspects of carbon tetrachloride hepatotoxicity

Creator:: Kaufman, Stuart Neil
Abstract:: The temporal relationships among selected correlates of hepatocellular damage were investigated in cordotomized, hypothermic rats intoxicated with carbon tetrachloride (CC1₄). Rats were spinally transected between C6 and C7 and allowed to become hypothermic. CC1₄ (1.25 ml/kg ip) was administered as a 1:1 solution in corn oil. Plasma alanine aminotransferase (ALT)...
Resource Type:: Masters Thesis
Full Text:: hydroperoxides. Lipids 12, 894-900. Gingerich, W. H., Weber, L. J., and Larson, R. E. (1977). Hepatic

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

Creator:: Hoyt, Dale G.
Abstract:: BCNU caused severe cholestasis in rats after a single intraperitoneal injection. The cholestasis was characterized by a selective reduction of the bile salt independent bile flow to 11% of control. Decreased food or water consumption by the treated rats apparently did not contribute to cholestasis. Measurements of plasma Na⁺ and...
Resource Type:: Masters Thesis
Full Text:: : /T (- / Lc ...Icy 't "---.. I 10 / Robert E. Larson, Ph.D. BCNU caused severe cholestasis in rats

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

Creator:: Hult, Richard Lee
Abstract:: An enhancement of the therapeutic effect and/or a reduction in the toxicity have been shown by a variety of antineoplastic compounds when glucose is added to the treatment schedule. A possible explanation for this involves a selective change in intracellular pH of the tumor tissue initiating a greater uptake of...
Resource Type:: Masters Thesis
Full Text:: Dr. Robert E. Larson An enhancement of the therapeutic effect and/or a reduction in the toxicity

The effects of increased body burdens of lead on lindane and dieldrin toxicity

Creator:: Cress, Charles Raymond, 1942-
Abstract:: The entire human population is chronically exposed to various contaminants, including lead and chlorinated hydrocarbon pesticides. Studies were undertaken to assess the effects of chronic exposure to lead on the toxicities of two such pesticides, lindane and dieldrin. Mice were given lead as the acetate in drinking water, at levels...
Resource Type:: Dissertation
Full Text:: Raymond Cress ACKNOWLEDGEMENTS Thanks are expressed to my major professor, Dr. Robert E. Larson, for

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Creator:: Giese, Neill Alan
Resource Type:: Masters Thesis
Full Text:: Privacy Dr. Robert E. Larson Carmustine (BCNU) is an important anti-tumor agent that is currently

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Creator:: Hult, Richard Lee
Abstract:: The relationship of intracellular drug levels and resultant drug activity to intracellular pH (pHi) was studied in the experimental tumors. Glucose (5 g/kg) and/or sodium oxamate (0.1 mmol) were administered to Walker 256 ascites cells and Ehrlich ascites cells, in an attempt to alter pHi as measured by the distribution...
Resource Type:: Dissertation
Full Text:: : Robert E. Larson The relationship of intracellular drug levels and resultant drug activity to

Hepatic mixed function oxygenase activity in rats during cholestasis following 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) treatment

Creator:: Stolzenbach, James Carlson, 1954-
Abstract:: Rats were given single i.p. injections of BCNU to investigate changes in hepatic cytochrome P-450 content and specific activity in male rats. Microsomal P-450 levels were unchanged from 6 hours to 7 days after BCNU treatment but by day 21 they had decreased 45%. Ethylmorphine N-demethylase activity (nm product x...
Resource Type:: Dissertation
Full Text:: -(2-chloroethyl)-1-nitrosourea (BCNU) Treatment Abstract approved: Redacted for Privacy Robert E

The effects of L-ascorbic acid, thiamine HCl, or L-cysteine on ethanol and acetaldehyde blood levels and disposition

Creator:: Acholonu, Wilfred W.
Abstract:: The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on acetaldehyde blood levels and disposition were investigated in acetaldehyde- treated rats. Rats were treated with ascorbic acid (2 mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one hour before the administration of acetaldehyde (6 mmoles/kg). The results show that each...
Resource Type:: Masters Thesis
Full Text:: are extended to Dr. Mervin J. Moldowan and Dr. Robert E. Larson for their guidance and encouragement

Hepatotoxicity of monochlorobenzene in rats and rainbow trout

Creator:: Dalich, George M.
Abstract:: The hepatotoxicity of CB was studied in the Sprague-Dawley rat and rainbow trout. In rats, an ip dosage of 9.8 mmol/kg CB (~̲ LD10) produced evidence of liver toxicity over a 72 hr time course. Sulfobromophthalein (BSP) retention maximized 3-16 hr post treatment and normalized after 72 hr whereas plasma...
Resource Type:: Dissertation
Full Text:: ---7 Redacted for Privacy Abstract Approved: Robert E. Larson The hepatotoxicity of CB was studied

ScholarsArchive@OSU

Impaired organic anion excretion and cholestasis caused by 1,3-bis-(2-chloroethyl)-1-nitrosourea (carmustine or BCNU) in rats

The effect of hypothermia on biochemical and morphological aspects of carbon tetrachloride hepatotoxicity

Characterization of cholestasis induced by 1,3-bis-(2-chloroethyl)-1-nitrosourea in rats

A comparison of the effect of pH change upon the uptake of 5-fluorouracil into rat liver and Walker 256 carcinosarcoma slices

The effects of increased body burdens of lead on lindane and dieldrin toxicity

The effect of carmustine (BCNU) on hepatic UDP-glucuronyltransferase activity in the rat

Intracellular pH and the uptake of carcinostatic drugs by selected experimental tumors

Hepatic mixed function oxygenase activity in rats during cholestasis following 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) treatment

The effects of L-ascorbic acid, thiamine HCl, or L-cysteine on ethanol and acetaldehyde blood levels and disposition

Hepatotoxicity of monochlorobenzene in rats and rainbow trout

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