We present a method for deterministically solving the consistent temperature and frequency dependent phonon radiative transport problem. We use the single relaxation time (SRT) approximation in the Self-Adjoint Angular Flux (SAAF) form with discrete ordinates (S_N) angular discretization method and continuous finite element method (CFEM) for spatial discretization. Included are...
Tolerance analysis is a major link between design and
manufacturing. An assembly or a part should be designed
based on its functions, manufacturing processes, desired
product quality, and manufacturing cost. Assembly tolerance
analysis performed at the design stage can reduce potential
manufacturing and assembly problems. Several commonly used
assembly tolerance...
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
The Human Immunodeficiency Virus -1 (HIV-1) has been the source of substantial human misery since it was first discovered in the early 1980s. Despite remarkable progress that has been made towards understanding HIV- 1, there is no cure, no vaccine and life-prolonging therapies are beyond the reach of millions in...
Liberalization of electricity markets has become a dominant energy sector reform for most of the European Union (EU) countries since 1990s. Despite initial expectations that liberalization will reduce electricity prices and strengthen overall energy security, outcomes of the deregulation reforms proved to be unclear and even contradictory. This study seeks...
The first goal of this study was to evaluate the roles of different intracellular
proteolytic systems in accelerated skeletal muscle protein degradation. Total,
myofibrillar and non-myofibrillar proteolysis were determined in cultured L8/CID
muscle cells. Calpain proteolysis was assessed by over-expressed calpastatin inhibitory
domain (CD). Lysosomal proteolysis was determined in the...
The fundamental objective of a design engineer in performing tolerance technology is to transform functional requirements into tolerances on individual parts based on existing data and algorithms for design tolerance analysis and synthesis. The transformation of functional requirements into tolerances must also consider the existing process capabilities and manufacturing costs...
An impediment to use of exotic and bioengineered trees in many places is their propensity for spread by pollen and/or seeds. Our laboratory has been using gene editing to induce mutations in floral genes as means to impart stable and reliable genetic containment when this is desirable from social (markets,...
The emergence of high explosives on the battlefield can be defined both literally and figuratively as a seismic event in the landscape of modern warfare. High explosives first came into common use in war in 1914. By the end of World War I just four years later, more than 2.5...