Phospholipase C-β (PLC-β) isozymes are key effectors in G protein-coupled
signaling pathways. Prior research suggested that some isoforms of PLC-β may exist
and function as dimers, but little is known about dimerization of PLC-β. Data from coimmunoprecipitation
assays of differentially-tagged PLC-β constructs and sizeexclusion
chromatography of native PLC-β support homodimerization...
In the summer of 2007, physical measurements including velocity from acoustic Doppler current profilers, surface gravity wave heights measured acoustically, and temperature from thermistor chain arrays were collected along- and across- the mid to inner shelf (water depths from 10–60 m) in northern Monterey Bay. The oceanic response to a...
The temperate water fisheries for albacore in the North Pacific seem to exploit somewhat similar segments of the respective populations present in the various localities. It is clear that in most of the exploited populations two or at most three year classes are highly dominant. In the California fishery from...
DNA methylation is a well-recognized epigenetic mechanism that has been the subject of a growing
body of literature typically focused on the identification and study of profiles of DNA methylation and their
association with human diseases and exposures. In recent years, a number of unsupervised clustering algorithms,
both parametric and...
The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
During the upwelling season in central California, northwesterly winds along the
coast produce a strong upwelling jet that originates at Point Año Nuevo and flows
southward across the mouth of Monterey Bay. A convergent front with a mean
temperature change of 3.77 ± 0.29°C develops between the warm interior waters...
The promise of epigenome-wide association studies (EWAS) and cancer specific somatic changes in improving our understanding of cancer coupled with the decreasing cost and increasing coverage of DNA methylation microarrays, has brought about a surge in the use of these technologies. Here, we aim to provide both a review of...
The potential influence of underlying differences in relative leukocyte distributions in studies involving blood-based profiling of DNA methylation is well recognized and has prompted development of a set of statistical methods for inferring changes in the distribution of white blood cells using DNA methylation signatures. However, the extent to which...
Background: There has been a long-standing need in biomedical research for a method that quantifies the normally mixed composition of leukocytes beyond what is possible by simple histological or flow cytometric assessments. The latter is restricted by the labile nature of protein epitopes, requirements for cell processing, and timely cell...