Product formulation and in vitro dissolution characteristics of sustained-release chewable tablet dosage
forms are presented in chapter one of this thesis. In vivo
single dose and multiple dose studies of two
sustained-release formulations as well as one conventional
dyphylline formulation are described in chapter two. The
pharmacokinetics of dyphylline following...
In this thesis, A nonlinear methodology for the control of the highly
maneuverable, high performance aircraft HARV (F-18) is studied by using sliding-mode
control (SMC). This control law, which takes a continuous function when the
input constraints are not considered, satisfies the reachability condition by which
concerned states are driven...
The anticonvulsant drug carbamazepine (CBZ) is a commonly prescribed drug that is used to treat patients with neurological disorders including epilepsy and bi-polar disorder. CBZ has a narrow range of efficacy: Below the therapeutic dose, seizures and other conditions are not controlled, and above the recommended window, patients experience side...
Paper-based assays for HIV diagnosis are cheap, portable, and require little to no skilled training, electricity, or expensive equipment to perform successfully. However, there is a need for tests with lower limits of detection (LOD) for diagnosing infection at the earliest stages. Effective labeling to increase signal-to-noise ratio is critical...
Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
We consider the problem of computing the cannonical polyadic decomposition (CPD) for large-scale dense tensors. This work is a combination of alternating least squares and fiber sampling. Data sparsity can be leveraged to handle large tensor CPD, but this route is not feasible for dense data. Inspired by stochastic optimization's...
Pseudomonas syringae are plant pathogenic bacteria that cause disease by rapidly multiplying within the aboveground tissues of host plants. Growth of P. syringae within plant host tissues requires the disarmament of host immune defenses that limit microbial growth. To combat host defenses, P. syringae deploys a type III secretion system...
Previous studies indicated that fertigating with nitrogen (N) was more effective than using granular N fertilizers in production of northern highbush blueberry (Vaccinium corymbosum L.). To build on these findings, four studies were conducted in western Oregon to determine whether fertigation was also an effective method for applying other nutrients,...