Tissue distribution studies of calcium and lead in brain tissue
of rats were increased subsequent to a single intravenous injection
of lead, 10 mg/kg, in the form of lead acetate. Time-course
studies demonstrated that brain concentrations of calcium and lead
(in terms of wet tissue weight) were found to be...
Injection of a 2.0 mg Cd
²⁺
/kg B.W. (I.P. as CdC1
₂
in
.05 M NaAc, pH = 6.9-7.2, .15 M or p = .15 with NaCl) resulted
in a decrease in ceruloplasmin (EC 1.12.3) p-phenylenediamine
oxidase activity within one hour of injection.
Maximal decrease (40%) occurred within six...
Forced vital capacity lung expiration examinations of nonsmoking
and cigarette-smoking male sample populations were compared to
determine if the 75 to 85 percent segment was a more sensitive test
of early lung dysfunction. The nonsmoking population was composed
of 240 men who were tested for values of forced vital capacity...
Selenium deficiency in rats results in increased carbon metabolism,
approaching twice the rate of selenium supplemented animals
(normal). This is also reflected in a 50 percent increase in lysosomal
enzyme activity in tissues of selenium deficient animals.
Isolation of rat liver lysosomes shows a 17 percent increase in
membrane thickness...
The light-adapted crayfish, Pacifastacus trowbridgii (Stimpson,
1957), displayed a behavioral response to exposure to 300 kV x-rays at
exposure rates of 10 to 30 R/s. Within this range, the proportion
of subjects that responded increased with an increase in exposure
rate. The response latency was inversely proportional to the
exposure...
The metabolism of pyrrolizidine alkaloids and other
drugs was studied with regard to nutritional status and
species differences. Pyrrolizidine alkaloids which are biotransformed
to severely toxic metabolites were isolated
from tansy ragwort (Senecio jacobaea). Semi-purified alkaloid
crystals containing five alkaloids (senecionine, seneciophylline,
jacobine, jacoline, and jacozine) were prepared
and found...
The binding of estrogen to endometrium and uterine arteries of the ewe was investigated by use of a [³H]estradiol exchange assay and by incubating whole tissue aliquants with [³ H]estradiol, a method which permits quantification of bound estrogen translocated from the cytoplasm to the nucleus. Five ewes were necropsied on...
A study was performed to assess the uptake and retention patterns
of cesium-134 in the gray-tailed vole, Microtus canicaudus Miller. To
furnish a realistic source of contaminated food for the voles, wheat
seedlings were raised in hydroponic solutions to provide radiocesium
labeled wheat clippings. The hydroponic system was designed to...
The testes of the gray-tailed vole (Microtus canicaudus Miller) exhibited a high affinity for selenium relative to other selected tissues. Uptake of selenium-75 in the testis-epididymis complex was delayed relative to uptake by the whole body, kidney, and liver. This pattern of uptake suggested that selenium was metabolically incorporated into...
This was a study designed to determine the occurrence of recovery
from radiation damage in Taricha granulosa. Irradiation with either
gamma or x-ray sources in the range of 96-10,000 rads was given. (The
mean or median survival times were determined.) Doses were fractionated
and the survival times for the same...