Pseudomonas aeruginosa is an opportunistic human pathogen that infects immunocompromised individuals such as those suffering from burns or the genetic disorder cystic fibrosis. This organism utilizes a cell-cell communication mechanism known as quorum sensing (QS) to coordinate virulence gene expression and biofilm formation. It has three interconnected QS systems, namely...
In an increasingly computation-driven world, algorithms and mathematical models significantly impact decision making across various fields. To foster trust and understanding, it is crucial to provide users with clear and concise explanations of the reasoning behind the results produced by computational tools, especially when recommendations appear counterintuitive. Legal frameworks in...
Cooperative behaviors in bacteria are increasingly appreciated for their relevance to microbial ecology and utility as model systems for social evolution. One example is the secretion of siderophores, a structurally diverse group of compounds that chelate extracellular iron. Siderophore production is considered cooperative because the benefits can be shared with...
The history of a software project plays a vital role in the software development process. Version control systems enable users of a software repository to look at the evolution of the source code, and see the changes that led to newer versions. Currently, version control systems provide commands that can...
The code reuse problem is a common software engineering problem in scientific computing. As a prevailing programming language in many scientific fields, Fortran does not provide support to address this problem. One particular reason is that Fortran lacks the support for generic programming. By applying program-generation techniques, we developed two...
Variability is an important and widely studied topic across domains such as version control, software product lines, and metaprogramming. This dissertation presents an investigation into the process of systematically adding variability to data structures and programs, leading to guidelines for variational data structures and implications for programs that create, manipulate,...
Landscape models for elk distribution developed at Starkey Experimental Forest and Range from 1993-1995 were tested on another landscape during 2003-2005 at Sled Springs Wildlife Demonstration Area. Using location data obtained from 23 wild elk captured and fitted with GPS telemetry collars, 8 spatial resource selection function models representing 8...
The quorum sensing regulatory pathway has been extensively studied for its impact on the virulence of Pseudomonas aeruginosa, an opportunistic pathogen that causes acute and chronic infections in immunocompromised individuals such as those suffering from the genetic disorder cystic fibrosis. Part of the quorum sensing pathway that has not been...
Pseudomonas aeruginosa is a ubiquitous environmental microbe, opportunistic pathogen, and a highly social organism. P. aeruginosa utilizes a wide array of cooperative behaviors to adapt to the environmental conditions around it. These behaviors include quorum sensing (QS), a form a cell-to-cell signaling that coordinates the expression of secreted products in...