Cells represent microcosms of spatial and temporal structural organization, with the achievement of internal spatial organization relying upon a collection of macromolecular motor complexes to transport and localize components throughout the cell. Cytoplasmic dynein is one such motor complex, and is the principal ATP-dependent motor for retrograde transport along microtubules...
Generating abundant, renewable energy from Earth’s oceans is an attractive option for meeting increasing energy demand. Marine renewable energy also comes with the variability of renewable sources, which impact the reliability and power quality of the electrical grid. On a transmission-level, this dissertation looks at ensuring reliability of the power...
High-pressure torsion (HPT) is an effective severe plastic deformation (SPD)
technique to produce bulk nanostructured materials (BNMs). These BNMs often show a combination of exceptional mechanical and physical properties. Processing of single metals and alloys by HPT has been understood that the homogenous microstructures can be achieved throughout the disk...
Most of the concrete in the world is produced using hydraulic cement (ordinary portland cement, OPC) and siliceous or alumino-siliceous supplementary cementitious materials (SCM). Due to the shift in focus toward environmental sustainability within the construction industry, alkali-activated cementitious systems (AAC) have gained significant attention to reduce the carbon footprint...
To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
In coastal and ocean engineering, understanding the ocean environment and the forces from waves, tsunamis and waterborne debris on structures and floating bodies is an important aspect of designing safe and effective infrastructure. Understanding the impact of these forces on structures becomes an important question in the design process. Answering...
Understanding the interplay between energy and water is central to effective natural resource management. With enough energy it is possible to secure sufficient water, with enough water it is possible to produce nearly boundless energy. The sun is the engine which drives the availability of both these resources; nearly every...
We have sufficient evidence that our historical management of natural resources is not sustainable. Food production is stagnating or declining. Nonrenewable energy sources on which the energy sector has historically depended are being rapidly depleted. Water resources, for which the energy and food sectors compete, are being depleted and impaired....
In biology, function and disease are closely intertwined, requiring the coordination of hundreds of intricate chemical reactions. Interdisciplinary cooperation between chemical and biological approaches is necessary to decipher the chemical links between physiological and pathological conditions. In this arena, the precision tools made possible with chemical biology can manipulate and...