A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
Herein, we report the successful development of a novel nanosystem capable of an efficient delivery and temperature-triggered drug release specifically aimed at cancer. The water-soluble 130.1 ± 0.2 nm iron oxide nanoparticles (IONPs) were obtained via synthesis of a monodispersed iron oxide core stabilized with tetramethylammonium hydroxide pentahydrate (TMAOH), followed...
This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.chemmater.5b03128
This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. To assess the potential of the developed therapy, dendrimer-based...
The variability introduced into measurements by a measuring instrument is referred to as measurement instrument precision. Experimental procedures and analysis methods exist when measurements are repeatable and can be repeated on the same item. However, when the measurements are destructive and repeated measurements are not possible, estimating measuring instrument precision...
Chloroplast DNA (cpDNA) and mitochondrial DNA (mtDNA) are often used for the study of plant genetics and evolution. Plastid and mitochondrial genome sequences have allowed us to investigate plant evolution on a genetic level to infer molecular evolutionary rates, population-genetic processes, co-evolutionary phenomena, and numerous evolutionary questions and hypotheses. Ficus...
Starch is a significant component of the human diet and the glucose produced through its digestion provides a critical source of energy. When starch enters the mouth, salivary α-amylase hydrolyzes it into maltooligosaccharides (MOS, degree of polymerization [DP] 3-20) and maltopolysaccharides (MPS, DP >20). Previous studies have found that humans...
Spray drying has been widely used in food science for long-term storage of products such as powdered milk, and it has recently been used for preservation of more temperature sensitive products such as human blood plasma and single-cell organisms. However, there are no previous reports of successful spray drying of...
Selective laser melting (SLM) is an additive manufacturing (AM) process that uses a laser beam to melt metal powder as it is spread onto the build surface using a roller or scraper, followed by rapid solidification to manufacture a 3D component, one layer at a time.
In SLM process, density...
Ovarian cancer, “the silent killer,” is one of the deadliest gynecological diseases due to delayed diagnosis, leading to a heavily disseminated and aggressive metastatic cancer. Therapeutic options are limited at stages III-IV of ovarian cancer, in which debulking surgery and cytotoxic chemotherapy remain the mainstays of
intervention. However, these therapeutic...