Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
The marine environment is experiencing increased human-induced stress, compounded by natural and human-induced (global warming) climatic changes. “Freedom of the sea” is no longer a viable option as marine resources become increasingly scarce. Both fishermen and managers must work cooperatively and diligently to monitor the existing limited resources. In order...
Many failures of interpersonal communication and coordination in the aircraft cockpit have been found to occur as a result of poor management of flightdeck 'resources'. Crew Resource Management (CRM) is a concept that has evolved within the aviation community to specifically address this issue of resource management. The concept of...
It has been established that intercollegiate sport is an important social institution for student athletes of color in the United States (Coakley, 2012). White intercollegiate coaches have a prominent influence on the academic, athletic, social and emotional development of student athletes and therefore must be tuned into variation in cultural...
Individuals who have been traumatized have the opportunity to experience posttraumatic growth, conceptualized as positive changes that result from navigating highly challenging life circumstances (Tedeschi & Calhoun, 2004). The current model of posttraumatic growth (Calhoun, Cann, & Tedeschi, 2010) is based solely on cognitive-emotional processing yet by examining the role...
The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
DNA damage, if not repaired, can become a mutation. Mutation
accumulation is associated with initiation and progression of tumorigenesis. DNA
mismatch repair (MMR) is required for maintaining genetic stability by repairing
replication errors. Biochemical studies have shown that MMR also recognizes
mismatch-causing DNA lesions, suggesting the role of MMR in...
Climate change will require families to withstand and adapt to potentially novel impacts in their forests, requiring both ecological and social resiliency. When facing a future of complex and uncertain conditions, family forest owners need more information on the magnitude and direction of change, which can be best accomplished through...