There is a significant need for technological advancement in blood processing. New technologies in rapid processing of frozen blood products could significantly improve management of the blood supply chain in the United States by enabling on-demand use of frozen blood products that can be stored for 10 years instead of...
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Full Text:
-Sanchez, Z., Black, C., Maier, C.
S., Williams, D. E., ... & Ho, E. (2014). SUV39H1/H3K9me3 attenuates
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic
prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well
tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be...
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
Full Text:
, Palomera-SanchezZ, Beaver LM, et al. (2014)
Effects of Sulforaphane and 3,3'-Diindolylmethane on Genome
Freshwater systems cycle carbon along a spatial and temporal biogeochemical continuum, across which ecosystem processes contribute to transformations of organic matter (OM). Various ecological constraints impact rates OM transformation and production and consumption of the energetic end of respiration, methane. Microbiological processing and complete reduction of carbon substrates to methane...
The agricultural sector is one of the largest contributors to global climate change but is also one of the most vulnerable to its impacts. Farmers are at increasing risk of livelihood loss, which produces risks for their physical and emotional wellbeing on a global scale. Swift and effective adaptation is...
This thesis conveys the key technical features and scientific applications of a particle-particle ballistic simulation tool (SpaceLab) as well as a high level overview of experiments it was designed for and executed on. SpaceLab simulates spherical particle interactions under any combination of self-gravity, sliding friction, rolling friction, Van-Der-Waals (VDW) cohesion...
Juniper (Juniperus spp.) encroachment into the sagebrush steppe ecoregion is one of the main causes of sagebrush degradation and can alter the understory vegetative community by outcompeting native shrubs and grasses, which reduces the available forage and cover for small mammals. Coyotes (Canis latrans) are generalist, omnivorous predators in the...
Wildlife managers often use species distribution models (SDMs) as an initial tool in conservation planning. Managers and researchers have made efforts to model the habitat and distribution of pygmy rabbits (Brachylagus idahoensis) across their historic range since the species was proposed for listing under the Endangered Species Act (USFWS 2003)....