Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line...
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Prodrug
Incorporated Into Nanoparticles
Michael A. Sandoval, Brian R. Sloat and Zhengrong Cui
College of
Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line...
Full Text:
From a Gemcitabine Prodrug Incorporated into
Lecithin-Based Nanoparticles
By
Michael
Anaerobic digestion of lipid-extracted algal biomass has been proposed as a method to
recover and recycle nutrients in algal biofuel systems. The purpose of this study was to quantify recoverable nitrogen and phosphorus from anaerobically digested C. vulgaris. Recoverable nutrients were deemed those present in the liquid phase of anaerobic...
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Microsoft Word - Thesis of Michael Gordon Final Draft No
Cancer is class of diseases that has great diversity and unfortunately is one of the leading causes of death in the United States. Chemotherapy remains an important cancer treatment modality, and superior chemotherapeutic drugs are constantly being sought. Gemcitabine is an anti-tumor chemotherapeutic drug and it is the first line...
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Slide 1
By
Michael A. Sandoval
Dr. Zhengrong Cui
Dr. J. Mark
The smartphone is changing the way individuals interact with one another in society. Given the instant accessibility and multitude of socially iconic features, the contemporary handheld device grants users an unprecedented level of connectedness. However, despite the new breadth of access, perhaps the depth of the resulting social networks is...
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AN ABSTRACT OF THE THESIS OF
Michael J.C. Yee for the
1. Spatial climate variables are routinely used in species distribution models (SDMs) without accounting for the
fact that they have been predicted with uncertainty, which can lead to biased estimates, erroneous inference and
poor performances when predicting to new settings – for example under climate change scenarios.
2. We show...
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Daly, Scott D. Foster,
MichaelB. Ashcroft and David I. Warton
4
Web Appendix A: Algorithms and
1. Spatial climate variables are routinely used in species distribution models (SDMs) without accounting for the
fact that they have been predicted with uncertainty, which can lead to biased estimates, erroneous inference and
poor performances when predicting to new settings – for example under climate change scenarios.
2. We show...
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variables for
species distribution models
Stoklosa, J., Daly, C., Foster, S. D., Ashcroft, M. B., & Warton
1. Spatial climate variables are routinely used in species distribution models (SDMs) without accounting for the fact that they have been predicted with uncertainty, which can lead to biased estimates, erroneous inference and poor performances when predicting to new settings – for example under climate change scenarios. 2. We show...
Salmonid B lymphocytes were stimulated both in vivo and in vitro
and shown to produce antibody specific for the immunogen. A passive
hemolytic plaque assay was employed to demonstrate B cells producing
specific antibody. Characterization of plaque forming cells (PFCs)
involved sequential inhibition with a series of graded concentrations
of...
Letters included were sent to request increased funding for the Titles I and II of the Tribally Controlled College or University Assistance Act. Another letter to the director of Indian Health Services expresses concern over funding delays to the tribes for diabetes.
A publication containing advice on a wide range of gardening topics, including composting, container gardens, fall/winter gardens, fertilizing, insect pests, plant diseases, planting guidelines, raised beds, site selection, slugs, soil improvement, tilling, warm-season crops, watering, and weeds. Includes regional tips for various parts of Oregon.
Historians and sociologists of science often identify the efflorescence of social stud ies of science with the work of postwar American intellectuals such as Robert K. Merton and Thomas S. Kuhn. They often also refer to the views of Michael Polanyi (1891-1976) on the roles of tacit knowledge, apprenticeship, social...
Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...
Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
Global increases in ultraviolet-B radiation (UVBR:290-
320 nm) resulting from decreases in stratospheric ozone
concentration have the potential to alter marine primary
production and affect global climate and marine trophic
dynamics. Effects of UVBR on phytoplankton carbon fixation
were determined from open ocean exposure studies conducted
off the coast of...
Cytochrome B sequence data (FASTA format) from the paper “Seasonal distribution and environmental associations among late larval and juvenile rockfish (Sebastes spp.) off Oregon and Washington: new insights based on genetics”. The data was generated from a sample of 2534 unknown, field collected late-larval and juvenile rockfishes from the Pacific...
Whether media plays a contributory or a conduit role in the policy process has been a salient focus among policy scholars. If media plays a contributory role in the policy process, it not only shares similar policy core beliefs with advocacy coalitions, but also drafts and disseminates stories including policy...
In order to restore conifers in hardwood dominated riparian forests 25% of the
experimental reach forests alongside four streams in western Oregon was clearcut.
Clearcutting removed 400 m without residual buffers from a 1600-m streamside forest
reach in patchcuts spanning 100 and 200 meters. To assess the cumulative and direct...
I examined two amphibian communities to assess factors
that may impact amphibian biodiversity. The results suggest
that the potential factors which influence the maintenance
of amphibian biodiversity are multi-faceted and thus,
attempts to understand these factors must reflect these
complexities.
I investigated factors that influenced the susceptibility
of western toad...
On February 9th, 2014 Michael Sam stated in an interview with ESPN's "Outside the Lines" that he is gay. Since he was drafted, Sam will become the first ever openly gay player in NFL history. The following study aims to explore ESPN's coverage of Michael Sam, with a goal of...
Airborne Light Detection and Ranging (LiDAR) has become a popular remote sensing technology to create digital terrain models and provide forest inventory information. However, little research has been done to investigate the accuracy of using airborne LiDAR to perform measurement tasks common to Forest Engineering. This thesis contains two manuscripts...
Photoacclimation is the process by which plants and phytoplankton adjust the concentration and composition of their photosynthetic machinery (i.e. their photoacclimation state) in response to changes in their light or nutrient environment. The purpose of photoacclimation is to balance the rate at which light energy is absorbed with the energetic...
Recently concerns over anthropogenic carbon pollution have received increased global attention and research in forest biomass and carbon sequestration has gained momentum. Light Detection and Ranging (LiDAR) remote sensing has in the last decade demonstrated forest measurement and biomass estimation potential. The project objective was to compare LiDAR forest biomass...
Profitable, even-aged forest management depends on the early establishment
and rapid growth of each new forest crop. These, in turn,
require that the young trees have access to an adequate supply of
native resources of moisture, nutrients and light. In Mediterranean-type
climates, competition for soil moisture is the most serious...
The Experimental Advanced Airborne Research Lidar ‐ B (EAARL‐B), which was built and deployed by the U.S. Geological Survey (USGS) in 2014, is a novel topographic‐bathymetric lidar system. While retaining a number of features that were pioneered in the original National Aeronautics and Space Administration (NASA) EAARL system (e.g., low...
This investigation assessed the effectiveness of an adolescent substance abuse treatment program that incorporated "Rites of Passage." Named Gender Based Treatment (GBT), the treatment program sought to address the adolescents' developmental needs through the use of rituals, myth and story telling, and rites of initiation.
Employing quantitative and qualitative analysis,...
Mean weights, lengths, and condition factors of three isozyme
phenotypes of lactate dehydrogenase (LDH) enzyme differed significantly
for experimentally reared winter steelhead trout (Salmo
gairdneri) fry. Time of emergence from the gravel was unrelated
to LDH phenotype. Relative mortality of the phenotypes between
eyed-egg stage and emergence was unaffected by...
Cooperative work experience in agricultural education is one
form of supervised occupational experience that provides the student
in agriculture with practical application of skills and knowledge in
one of the many agricultural occupations. Cooperative work experience
students are placed with employers in agribusiness service,
processing, or in distribution for work...
Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Research in the miniaturization of thermomechanical systems in recent years has proven to be both rewarding and challenging. Micro-scale devices have tremendous technological potential but come with a new set of design problems. One such problem is energy storage. Heat actuated systems, driven primarily by thermal energy, take advantage of...
Freshwater (FW) and seawater (SW) acclimated yearling coho salmon, Oncorhynchus kisutch, were subjected to severe confinement stress in FW, SW, or a medium (1/3 SW) that was approximately isosmotic to the fish's blood. Chronic stress caused osmotic imbalances in FW and SW, but not in 1/3 SW. In SW, blood...
The ability of the resin to deform plastically can be an
important factor when considering the mechanical properties of particleboard.
Between resin droplets there exists an unbonded region
that forms the surface for a crack. When particleboard is deformed
stress concentrations develop at the crack tips in the voids. A...
Past research has implied that differences in blender performance
between commercial and laboratory particleboard blenders
may not be attributed to resin distribution between screen fractions,
as is commonly believed in the industry today, but to which particles
within a screen fraction have resin and which do note
To test this,...
Since the decline of salmonid populations in the Pacific Northwest, supplementation programs have become frequently implemented by hatcheries as a way to protect and conserve wild stock. However, hatchery-reared fish have lower fitness than wild fish which is likely due to adaptation to the hatchery environment, i.e., domestication selection. Fish...
The global positioning system (GPS) has come into widespread use for many forestry applications. However, there is still some uncertainty as to how receivers perform in dense forest, where trees interfere with the GPS signal and increase error. These two manuscripts examine GPS accuracy and overall effectiveness within second growth...
Falls, particularly those due to slips, constitute a major health risk for older
adults. Past research has found that individuals can learn not to fall through repeated
exposure to a slipping perturbation. Slips can be unpredictable, however. The goal
of this study was to determine whether similar adaptations would occur...
Acoustic scanned holography is a method of lensless photography
which uses sound waves to construct the hologram and light waves to
reconstruct the image. The receiving transducer scans a plane area
containing the sound field generated or scattered from the objects. In
simultaneous source receiver scanning, both the source and...
Agronomic and microbiological studies were conducted on "Anchor" alfalfa (Medicago sativa L.) established from uninoculated seed on three Aridisols in central Oregon. Significant responses to 230 Kg N per ha (NH₄NO₃), which was applied in mid-April and after each first and second harvests, were observed in yield parameters of the...
There are numerous techniques for improving the mixing of fuel and
oxidant species. However, many of these methods cannot be applied to combustion
systems due to material limitations. A means of mixing the reacting species without
physically invading the flow stream is therefore desired.
In this work, induced electromagnetic forces...
Commercial inoculant products for subclover that are marketed in the Pacific Northwest were evaluated in field trials (supplemented by appropriate laboratory analysis) at four sites in southwest Oregon. The materials tested were Nitragin (Milwaukee, WI) and Northrup-King (Minneapolis, MN) peat-based inocula, and Celpril (Manteca, CA) inoculated, lime-pelleted subclover seed. Duplicate...
The research developed a methodology to code and quantify eye movement patterns as a function of a neuro-linguistic programming strategy elicitation process. Secondarily the research established methodology that identified the degree of consistency among certain certified Neuro-Linguistic Programming Practitioners while they rated eye movements. The study reviewed literature in the...
The goal of this report is to develop information to benefit the planning and operation of marinas within the CREST area, as well as to generate data for use by local Chambers of Commerce, planners, regulatory agencies, Port Authorities and private developers. It is, however, the commercial, charter and recreational...
Although much has been written describing the
various reactions to the origin of Species in America, the Mormon reaction to Darwinism has been largely ignored. This dissertation will recount the history of this reaction as exemplified by the life and works of B. H. Roberts. Roberts's intellectual pursuits early in...
Dissolved organic matter (DOM) is a critical component of the carbon cycle linking terrestrial and aquatic ecosystems. Although many factors influence DOM fluxes and quality in rivers, controls on DOM compositions in catchments of the western U.S. are poorly understood. UV and fluorescent spectroscopy is a simpler, faster, and less...
The purpose of this study is to investigate the role of the
source of the external trade statistics in measuring the price
responsiveness of foreign demands and relative price competitiveness
of the major exporting countries in trade of agricultural commodities
in international markets. In particular, the papers included in this...
Randomized trials are the gold standard for the clinical assessment of a new treatment
compared to a placebo or standard of care. Often in clinical trials, patients are
accrued sequentially rather than all at once. Thus, the data from such a trial becomes
available sequentially to the researcher. Monitoring and...
Global increases in ultraviolet-B radiation (UVBR) have the potential to alter marine primary production and to affect carbon cycles and marine trophic dynamics. Estimates of UVBR induced photoinhibition have varied greatly, indicating that a common dose-response by marine phytoplankton may not occur from place to place. An action spectrum describing...
For the first objective of this thesis, we attempt to understand the role of water flow and directionality in determining steelhead (Oncorhynchus mykiss) and spring/summer and fall Chinook (O. tschawytscha) migration patterns within the Columbia River Estuary and plume by integrating recent advances in biotelemetry and environmental observation and forecasting...
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_____________________________________________________________________
Carl B. Schreck
For the first objective of this thesis, we attempt to understand the role
This dissertation focused on data mining in food science research and on the technical functional properties of wheat straw-derived biorefinery-byproduct fiber preparations as related to potential applications as food ingredients. This first study evaluated the importance of electronic bibliographic database selection and multiple database usage during the information retrieval phase...
Aging and excessive weight appear to be problematic to lateral balance related to falls. Strong frontal plane hip muscle strength is needed to stabilize the hip statically during single leg stance or dynamically during lateral stepping; however, the length of single leg stance time and maximum hip abduction angle during...
The present study investigated the effects of stress and exercise on seawater (SW) adaptation and cortisol dynamics in juvenile steelhead (Oncorhynchus mykiss). To examine the effects of stress, fish acclimated to freshwater (FW) were subjected for 3 hours to confinement stress in FW, and subsequently SW (25 ppt) was introduced...
The effect of canopy orientation on fruiting performance of 'Beurre
d'Anjou' pears (Pyrus communis L.) and postharvest urea spray on ovule
longevity and fruit set of 'Doyenne du Comice' pears were studied.
Hedgerows of 'Beurre d'Anjou' pear trees planted in 1969 in two
orientations north-south (N-S) and east-west (E-W) were...
A linearized model with two vertical modes has been developed to understand observed characteristics of monthly variability in the Equatorial Pacific from TOPEX/POSEIDON measurements of Sea Surface Height (SSH). The 2-mode model is obtained from an equatorial beta plane model that has been linearized about a geostrophically balanced mean flow...
Falls are a significant public health issue for older adults, with different fall rates and risk factors among genders. In order to slow or stop a fall, an individual must be able to produce significant eccentric joint power in the lower extremities. It is unclear whether there is a relationship...
Pacific sardines (Sardinops sagax) are an economically and ecologically important forage fish which transfer energy from planktonic primary producers and secondary consumers to upper trophic predators. Previous genetics studies of Pacific sardine suggested a panmictic population with a shallow genetic structure. However, more than one subpopulation within the Central California...
Four different plot types were established in shrub and tree comunitities in Little Elk Valley in southwest Oregon. Ten functional (F) plots were cleared of all vegetation in a radius of three times the height of the surrounding vegetation around a single Pacific madrone (Arbutus menziesii Pursh.) tree. Ten competition...
Photosynthetic response to light and temperature was modeled using data from a small red alder (Alnus rubra B. ) community growing in a controlled environment chamber linked to the computer. This new system controls air temperature, root temperature, and vapor pressure over a wide range, and both light intensity and...
The objective of this study was to examine the life history of
vine maple on the H. J. Andrews Experimental Forest. This study was
conducted as a part of an I. B. P. general study of understory biomass
and productivity. The specific objectives were to 1) estimate the
contribution of...
'Golden Delicious' winter squash (GDWS), Cucurbita maxima Duchesne, provides significant amounts of pollen (24 mg) and nectar (236 μl), but with a low reward of 14% nectar sugar. The quantity of nectar produced per GDWS flower differed between sites and floral sex. The GDWS male flowers had 25% higher sugar...
Cyprinid herpesvirus 3 (CyHV-3), commonly known as koi herpesvirus (KHV), is a member of the Alloherpesviridae, and is a recently discovered emerging herpesvirus that is highly pathogenic for koi and common carp. Our previous study demonstrated that CyHV-3 becomes latent in peripheral white blood cells (WBC). In this study, CyHV-3...
Little is known about the fall and winter ecology of hibernating bats in western North America. Filling knowledge gaps for these populations has become more urgent with the westward spread of the white-nose syndrome, a disease that infects bats during hibernation. Due to the thermal requirements of the fungal pathogen...
Cheddar Cheese samples (good cheese, weak cheese, cheese made with pasteurized milk, cheese made with heat-shocked milk, cheese from production plant A, cheese from production plant B, cheese made with adjunct culture, and cheese made without adjunct culture), were evaluated during the ripening stage. Proteolysis was studied by a fractionation...
The tolerance of woody plants to picloram (4amino-3,5,6-trichloropicolinic acid) has been shown by field applications to vary from mild to extreme. A laboratory study was done to investigate the basic causes for this range of tolerance known to exist among three woody plant species, Fraxinus pennsylvanics, March, (green ash) resistant,...
The objectives of this study are to 1) qualitatively and quantitatively measure the odor-active compounds in ‘Marion’ blackberry; 2) compare the aroma profiles of advanced selections and new cultivars of thornless blackberry cultivars with ‘Marion’; 3) study the development of furaneol in ‘Marion’ during ripening and; 4) investigate the distribution...
Aflatoxins B₁, Q₁ and aflatoxicol, R [subscript o] F, but not B₂ were activated in the presence of NADPH by the 105,000 x g pellet from rainbow
trout (Salmo gairdneri), Mt. Shasta strain, liver to products lethal to
Bacillus subtilis GSY 1057 (metB4, hisAl, uvr-1). Electron microscopy
confirmed the microsomal...
One of the most economically important genes in squash (Cucurbita spp.) is the B gene which conditions precocious depletion of chlorophyll in preanthesis fruit. The B genes are found naturally occurring in at least three of the five domesticated species of Cucurbita, including C. pepo, C. maxima and, most recently...
This research investigates shape optimization process, using b-spline models and panel methods, to achieve a high lift to drag ratio for an aerodynamic structure. This research is a proof of concept for further research in aerodynamic shape optimization. The coupled process, involving the design and optimization of a random shape,...
Reprinted July 1997. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
At a state university in the Pacific Northwest, the authors surveyed 477 matriculating college students about their immunization status, knowledge, self-perceived risk, and health risk behaviors for hepatitis A and B vaccinations. Review of immunization records revealed that 10% of these students were completely immunized for hepatitis A and 58.8%...
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium and the microbiota. We found that, in the absence of B cells, or of IgA, and in the presence of the microbiota, the intestinal epithelium launches its own protective mechanisms, upregulating...
The four stories within, "Jim of India," "Shooting the Breeze," "Bridge," and "Point Reyes," are part of a longer work in progress, tentatively titled The Andy Stories. The stories follow Andy, a woman in her 50s, on a voyage across the continent and into herself. Of these, all are written...
The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...
A major barrier to air travel for people with disabilities is the general lack of accessible lavatories on board commercial passenger aircraft. A primary reason for this lack of greater accessibility is related to space. To design an airplane lavatory that is accessible, minimizes the risk of injury to both...
One of the pervasive problems arising in our modern, digital world surrounds data breaches where an adversary, through zero-day exploitations, phishing, or old-fashioned social engineering attacks, gains access to a service’s data stores. Our society increasingly relies on these cloud-based services for everything from our taxes to personal communication. As...
Wine volatile composition is one of the most important components of wine quality, and it is greatly affected by multiple factors, including grape variety, viticultural practices, and winemaking procedures. Pre-fermentation cold soak is one of the winemaking techniques widely undertaken by winemakers to modify their red wine quality. Imposing a...
The water status of grape vine throughout the growing season is a primary determinant of vine vigor and berry composition. The concentrations of volatile compounds and precursors in grape berries are highly influenced by viticultural practices. Imposing a water deficit on the vine during berry development is an important vineyard...