Retraction fibers (RFs) determine orientation of the cell division axis and guide the spreading of daughter cells. Long and unidirectional RFs, which are especially apparent during mitosis of cells in three-dimensional (3D) environments, enable improved control over cell fate, following division. However, 3D gel environments lack the cues necessary for...
The complexity of designing and testing today's system on chip (SOC) is increasing due to greater integrated circuit (IC) density and higher IO and memory frequencies. SOCs for the mobile phone and tablet market have the unique challenge of short product development windows, at times less than six months, and...
Ultra-wideband (UWB) radio has become an attractive alternative for wireless communications due to the robustness to multipath fading, low power transmission, mostly-digital implementation, and low cost. Furthermore, short-range, high data-rates applications are possible with UWB radios due to the wide spectral
allocations at 3.1 - 10.6 GHz.
This thesis presents...
High speed serial links are critical components for addressing the growing demand for I/O bandwidth in next-generation computing applications, such as many-core systems, backplane and optical data communications. Due to continued process scaling and circuit innovations, today's CMOS serial link transceivers can achieve tens of Gb/s per pin. However, most...
For the past half century, CMOS process scaling has followed Moore's law, approximately doubling transistor density every 18 months. While locally routed wires have generally scaled with transistor size, longer wires have scaled at a slower rate and in some cases have grown larger as chip size and complexity have...
Biorhythm theory proponents believe that humans have
a 23-day physical cycle, a 28-day emotional cycle, and a
33-day intellectual cycle. According to biorhythm theories
a person in the positive portion of any single cycle, the performance potential is enhanced for those tasks related to
that particular rhythm. When each cycle...
The focus of this thesis involves development of highly transparent, n-channel, accumulation- mode thin-film transistors employing a zinc tin oxide (ZTO) channel layer. ZTO-based transparent thin-film transistors (TTFTs) show improved device performance compared to ZnO-based TTFTs. An estimated peak effective mobility for these devices as high as ~100 cm² V⁻¹sec⁻¹...
The classical chi-square goodness of fit test and the Neyman smooth tests are generalized for arbitrarily right-censored samples. The test statistics are shown to have limiting chi-square distributions under completely specified (simple) null hypotheses and random censorship. Limiting distributions of the generalized chi-square goodness of fit tests are also established...
The problem of footstep level resolution indoor path tracking and gait velocity
lacks a good solution. The current solutions are either prohibitively expensive [4],
extremely invasive to deploy [1], or too inaccurate to achieve the sub meter level
resolution required to track foot paths. By combining existing pedestrian dead
reckoning...
As computation power continues to grow, the demand for data transfer bandwidth is also rising. This is reflected in the increasing data-rate of high-speed links. However, the increase in data-rate is sustainable only if the I/O energy efficiency improves as well. This dissertation explores several techniques to enable high-speed links...
Scaling the supply voltage into the sub/near-threshold domain is one of the most effective methods for improving the energy efficiency of next-generation electronic microsystems. Unfortunately, the relationship between low-voltage operation and radiation-induced soft error rate is not widely known, as little research has been previously performed and reported for soft-error...
An innovative silver nano-dimple arrays (Ag DAs)-integrated microfluidic device was developed to achieve highly sensitive fluorescence-based nucleic acid detection. The Ag DAs were utilized to produce surface plasmon resonance (SPR) for strong fluorescence enhancement. We systematically investigated the plasmon-enhanced fluorescence by controlling the nanostructure dimension of the Ag DA substrate....
Ultrawideband (UWB) communication is a promising technology for wireless body area networks (BANs), especially for applications that require transmission of both low and high data rates with excellent energy efficiency. Therefore, understanding the unique UWB channel propagation characteristics around the human body is critical for a successful wireless system, especially...
Indoor localization systems have a variety of applications such as tracking of assets, indoor robot navigation, and monitoring of people (e.g. patients) in hospitals or at home. Global positioning system (GPS) offers location accuracy of several meters and is mainly used for outdoor location-based applications as its accuracy degrades significantly...
Advances in low-power digital integration and microelectro-mechanical systems (MEMS) have paved the way for micro-sensors. These sensors are equipped with data processing capabilities along with sensory circuits. Sensor data are processed on these individual sensors and transmitted to the target (sink). Lowcost integration and small sizes of these sensors have...
It is well known that multipath effects cause inter-symbol interference (ISI) for high-speed signaling and ultimately limit the achievable data rate at any frequency band. In this thesis, we study several different methods to tackle this issue and provide solutions for establishing efficient wireless links that can provide several Gbps...
This dissertation presents an incremental analog-to-digital converter (ADC) with digital digital-to-analog converter (DAC) mismatch correction. A theoretical time-domain analysis technique was developed to predict the noise performance of the incremental ADC, and a new optimization technique was proposed to minimize the output noise.
In the calibration mode, the incremental ADC...
As CMOS processes keep scaling down devices, the maximum operating frequencies of CMOS devices increase, and hence circuits can process very wide band signals. Moreover, the small physical dimensions of transistors allow the placing of many more blocks into a single chip, including highly accurate analog blocks and complicated digital...
Field biologists are in need of more specialized and technical equipment than they are able to produce on their own in order to collect data more efficiently or gather data that is not currently available. This presents a challenge for design engineers because these products are typically highly specialized and...
As the number of autonomous data collection applications keep increasing, the demand for wireless sensor networks (WSNs) has seen explosive growth. In this dissertation, an ultra-low-energy WSN transmitter is developed to reduce the energy consumption of sensor nodes in WSNs. With an ultra-low-energy transceiver, it is possible to eliminate the...
The decrease of switching times accompanied by the corresponding increase of
clock speeds and data rates, contributes to improve the overall system
computational performance. At the same time, they also affect wireless
communications due to an increment in the emissions of electromagnetic
radiation on the radio bands.
In this dissertation...
Millimeter-wave (mm-wave) technology promises high speed, high system capacity and low latency interconnects with reduced cost. Applications like high data-rate wireless links, next generation automotive sensors and security body scanners highly depend on mm-wave technology innovations. As operating frequency moves to higher mm-wave bands, shrinking antenna dimensions enable co-integration of...
Background: Having conquered water surfaces worldwide, the semi-aquatic bugs occupy ponds, streams, lakes, mangroves, and even open oceans. The diversity of this group has inspired a range of scientific studies from ecology and evolution to developmental genetics and hydrodynamics of fluid locomotion. However, the lack of a representative water strider...
Three distinct methods to achieve the stereoselective synthesis of carbon-carbon bonds were investigated, encompassing: (i) the formation of axially chiral biaryl molecules by enantioselective Suzuki cross-coupling, (ii) the synthesis of α-phenylalkylboronic esters by enantioselective chain extension, and (iii) the stereospecific synthesis of alkenes by eliminative cross-coupling of enantioenriched sp³-hybridized carbenoids....
The prevalence of Tropilaelaps mercedesae and Varroa destructor in concurrently infested A. mellifera colonies in Thailand was monitored. We also assessed the fecundity of T. mercedesae and V. destructor in naturally infested brood and in brood cells deliberately infested with both mite genera. Results showed that the natural co-infestation of...
Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
Accurate estimates of mass-exchange parameters in transient storage zones are needed to better understand and quantify solute transport and dispersion in riverine systems. Currently, the predictive mean residence time relies on an empirical entrainment coefficient with a range in variance due to the absence of hydraulic and geomorphic quantities driving...
The variegated aqueous chemistries of metal cations are applied to the design and synthesis of non-toxic solution precursors suitable for additive printing of large-area oxide electronics. Polycondensation behaviors of aqueous Al+3 and PO4 +3 are manipulated in the deposition of atomically smooth amorphous aluminum oxide phosphate (AlPO) dielectric films. AlPO...
In the past two decades, the advancement in data collection and storage have led to the accumulation of complex datasets. Consequently, various industries have sought data-driven solutions to predict and detect anomalies. Temporal patterns have emerged as potential features in prediction models that could improve the performance of the identification...
Nanostructured ZnO films were obtained via thermal oxidation of thin films formed with metallic Zn-nanoparticle dispersions. Commercial zinc nanoparticles used for this work were characterized by microscopic and thermal analysis methods to analyze the Zn-ZnO core shell structure, surface morphology and oxidation characteristics. These dispersions were spin-coated on SiO₂/Si substrates...
In the Willamette Valley of Oregon, a combination of the need for rotational crops and an increased desire for biofuel production created interest in planting Brassica napus (canola). However, questions were raised arisen over the potential damage canola production could have on the preexisting Brassica vegetable seed industry. To address...
A class of inorganic thin-film transistor (TFT) semiconductor materials has emerged involving oxides composed of post-transitional cations with (n-1)d¹⁰ns⁰ (n≥4) electronic configurations. This thesis is devoted to the pursuit of topics involving the development of these materials for TFT applications: Deposition of zinc oxide and zinc tin oxide semiconductor
layers...
We apply GENMOM, a coupled atmosphere–ocean climate model, to simulate eight equilibrium time
slices at 3000-year intervals for the past 21,000 years forced
by changes in Earth–Sun geometry, atmospheric greenhouse
gases (GHGs), continental ice sheets, and sea level. Simulated
global cooling during the Last Glacial Maximum
(LGM) is 3.8°C and...
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northern polar regions during boreal
autumn, winter, and spring, consistent with the observed po-
lar
The West Antarctic Ice Sheet Divide (WAIS Divide, WD) ice core is a newly drilled, high-accumulation
deep ice core that provides Antarctic climate records of
the past ~68 ka at unprecedented temporal resolution. The
upper 2850 m (back to 31.2 ka BP) have been dated using
annual-layer counting. Here we...
NAND flash based solid state drives (SSDs) require out-of-place updating due to the characteristics of flash memories. In addition, due to the mismatched granularity between read/write and erase operations, a cleaning policy involving garbage collection and wear leveling has to perform data migration incurring high overhead. Another challenge is that...
The primary focus of this thesis is modifying the comprehensive depletion-mode model and extending its applicability to p-channel thin-film transistor (TFT) behavior and subthreshold (subpinchoff) operation. The comprehensive depletion-mode model accurately describes depletion-mode TFT behavior and establishes a set of equations, different from those obtained from square-law theory, which can...
The primary objective of this thesis is to develop a process for fabricating integrated circuits based on thin-film transistors (TFTs) using zinc tin oxide (ZTO) as the channel layer. ZTO, in contrast to indium- or gallium-based amorphous oxide semiconductors (AOS), is perceived to be a more commercially viable AOS choice...
Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate
sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and
genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe
conditional alleles of the dicer-related helicase, drh-3, that abrogate both RNA interference and...
Sequence data from nrITS and cpDNA have failed to fully resolve phylogenetic relationships among Pinus species. Four low‐copy nuclear genes, developed from the screening of 73 mapped conifer anchor loci, were sequenced from 12 species representing all subsections. Individual loci do not uniformly support either the nrITS or cpDNA hypotheses...
Four blackberry (Rubus L. subgenus Rubus Watson) cultivars (‘Obsidian’, ‘Black Diamond’, ‘Metolius’, ‘Onyx’) and two advanced selections (ORUS 1939-4 and ORUS 2635-1) were evaluated during the establishment years of an organic production system for fresh market. The planting was established in Spring 2010 using approved practices for organic production and...
Compared to conventional amorphous silicon (a-Si) TFTs, amorphous metal oxide TFTs have superior device performance such as
higher mobility, better sub-threshold swing, and lower off-state current. Amorphous metal oxide TFTs have an additional advantage
on the device uniformity due to the lack of grain boundary issues in the poly-Si TFTs....
For continuous time, finite state and action, Markov decision
chains, optimal policies are studied; (i) a procedure for transforming
the terminal reward vector is given and it is established that this
transformation does not alter optimal policies, (ii) decision chains
with absorbing states are studied and the results obtained are...
A new model of global climate, ocean circulation, ecosystems, and biogeochemical cycling, including a fully coupled carbon cycle, is presented and evaluated. The model is consistent with multiple observational data sets from the past 50 years as well as with the observed warming of global surface air and sea temperatures...
Both liquid and solid wastes from Pacific whiting surimi manufacturing were
characterized and value-added products were recovered. A proteinase in surimi wash
water (SWW) was determined to be cathepsin L with Mr 54,200 on SDS-substrate gel.
Heat treatment and acidification shifted the activity zone to M [subscript r] 39,500. No...
There are five main contributions of this dissertation. The first contribution is new closed-form expressions for channel capacity of a new class of channel matrices. The second contribution is the discovery of the structure for optimal binary quantizer and the associated methods for finding an optimal quantizer that maximizes mutual...
Low-power millimeter-wave (mm-wave) transceivers are of interest for achieving energy-efficient high data rate short-reach wireless and guided-wave links.
Spatial modulation or space-shift keying (SSK) can provide energy efficiency improvements by using antenna-switching or transmission direction switching for data modulation. Such links are particularly attractive at millimeter-wave frequencies due to small...
Wearable sensors with an inertial measurement unit (IMU) are popular for indoor positioning and activity pattern detection. The IMUs can be connected to a wireless transmission module, allowing users to monitor and process motion-related parameters remotely. Because of the complexity and uncertainty of signals in indoor environments, a radio frequency...
Nine Gray Podzolic soils from different physiographic regions
of Thailand were studied to determine their characteristics and
genesis in relation to their parent materials, land form, pedogenic
environment, classification and management. The clay was characterized
by X-ray diffraction and standard chemical and physical
analyses were performed. Mineralogy of the light...
I led a collaborative project involving a search for an evidence of a gravitational wave background (GWB) with all the spatial correlations allowed by general metric theories of gravity using NANOGrav’s 12.5 year data set. The search found no substantial evidence in favor of the existence of such correlations.
The...
The three studies that comprise this dissertation seek to answer significant
questions in paleoclimatology through unconventional applications of ice core
greenhouse gas data. These studies involve different gases and span the interval of time
between the Last Glacial Maximum and the Industrial Revolution, but are united by their
nontraditional use...
The purpose of this study was to investigate physical education
and sport in Thailand and, based upon expert opinion, to develop a
blueprint of physical education and sport for the nation building of
Thailand. The investigation concentrated on the history, role and
function, purpose of governmental involvement, and future prospects...
We explore the application of deep learning to the disparate fields of natural language processing and computational biology. Both the sentences uttered by humans as well as the RNA and protein sequences found within the cells of their bodies can be considered formal languages in computer science, as sets of...
Simultaneous translation, which translates concurrently with the source language speech, is widely used in many scenarios including multilateral organizations. However, it is well known to be one of the most challenging tasks for humans due to the simultaneous perception and production in two languages. On the other hand, simultaneous translation...
This dissertation consists of three essays that evaluate various types of health care policies from the social welfare perspective. Chapter 1 introduces the main ideas and framework of this dissertation. Chapter 2 evaluates the new co-payment policy, enacted on July 15, 2005 under Taiwan’s National Health Insurance (NHI). We show...
Labeling videos is costly, time-consuming and tedious. These costs can escalate in applications such as medical diagnosis or autonomous driving where we need domain expertise for annotation. Few-shot action recognition aims to solve this problem by annotation-efficient learning mechanisms.
This thesis presents MetaUVFS as the first Unsupervised Meta-learning algorithm for...
Smart home devices, such as voice assistants, smart lights, and smart video doorbells have become a part of end users' daily lives. Many of these devices combine their features with other services and smart devices to create a simple and efficient user experience. This is partly because of the contribution...
Real time indoor positioning awareness systems aim to add localization capabilities to upcoming wireless technologies that are quickly becoming an important feature for indoor environment. RF-based impulse-radio ultra-wideband (IR-UWB) is a promising technology for in-door positioning systems due to obstacle penetration capabilities, immunity to multi-path and fading, and high resolution....
Sea surface temperatures (SST) and inorganic continental input over the last 25,000 years (25 ka) are reconstructed in the far eastern equatorial Pacific (EEP) based on three cores stretching from the equatorial front (~0.01°N, ME0005-24JC) into the cold tongue region (~3.6°S; TR163-31P and V19-30). We revisit previously published alkenone-derived SST...
Incremental ADCs (IADCs) have many advantages for low-frequency high-accuracy data conversion—they are easy to multiplex between channels, need simpler digital decimation filter, and allow extended counting with a Nyquist-rate ADC. A single-loop incremental ADC was designed and fabricated in 90 nm for a biosensor interface circuit. It incorporates one integrator,...
A quantal response model, more general than the usual logistic
model, is introduced. This model takes into account sources of
variability, or experimental error, other than that arising from variability
in response between individual organisms (or other objects on
test). It is assumed that this extra source of variation is...
Support for low-carbon energy and opposition to new large dams encourages global development of small hydropower facilities. This support is manifested in national and international energy and development policies designed to incentivize growth in the small hydropower sector while curtailing large dam construction. However, the preference of small to large...
Arthropod communities in pear are conceptualized as hierarchically
organized systems in which several levels of organization or subsystems
can be recognized between the species population level and the community
as a whole. An individual tree is taken to be the community habitat with
arthropod subcommunities developing on leaf, fruit and...
The tropical Pacific Ocean is a climatically important region, home to El Niño and the Southern Oscillation. The simulation of its climate remains a challenge for global coupled ocean–atmosphere models, which suffer large biases especially in reproducing the observed meridional asymmetry across the equator in sea surface temperature (SST) and...
This study develops an improved method for understanding
economic production relationships in small scale
fisheries. This method postulates that gross revenue is a
function of physical input quantities, and is based upon
the transcendental logarithmic function to derive factor
share equations for each of the five inputs in the model....
Unlike other biosensing, electrochemical biosensor has the advantages of robustness, easy miniaturization, excellent detection limits, and capability in handling small analyte volumes. The detection selectivity of the electrochemical biosensors is mainly supported by bioreceptors. However, these receptors always suffer from the performance variation caused by the environment and the thermal-...
The natural environment provides important services and benefits to peoples’ health and lives. Conversely, environmental disservices can have negative impacts on humans such as through pollution, chemical toxins, and climate change. The combination of environmental services and disservices encompass how human health and wellbeing, and the environment are connected. As...
Data from nuclear ribosomal internal transcribed spacer regions (nrITS) and chloroplast DNA (cpDNA) have failed to resolve phylogenetic relationships in Pinus. To provide greater interspecific resolution, five low-copy nuclear genes were developed from mapped conifer anchor loci. Four genes were sequenced from species representing all Pinus subsections. Individual loci do...
Solid state luminescent sulfides are prepared as powders in order to elucidate the relationship between structure and light emission. While the sulfides studied in this dissertation are known phosphors, materials are investigated in a variety of new ways. Elementary properties and structures of MgS are reviewed, and preparation of MgS...
Simultaneous speech translation (SimulST) is widely useful in many cross-lingual communication scenarios, including multinational conferences and international traveling. Since text-based simultaneous machine translation (SimulMT) has achieved great success in recent years. The conventional cascaded approach for SimulST uses a pipeline of streaming ASR followed by simultaneous MT but suffers from...
In a process called quorum sensing (QS), the bacterial pathogen Pseudomonas aeruginosa uses small diffusible signals to coordinate cooperative behaviors via secreted “public goods”. Under QS-dependent growth conditions, social cheaters arise with mutations in lasR, the gene for the primary QS signal receptor. These cheaters do not produce public goods....
Most pathogen detection tests are imperfect, with a sensitivity < 100%, thereby resulting in the potential for a false negative, where a pathogen is present but not detected. False negatives in a sample inflate the number of non-detections, negatively biasing estimates of pathogen prevalence. Histological examination of tissues as a...
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Fisheries and Aquaculture, Mississippi State University, PO
Box 9690, Mississippi State, MS, 39762, United
To improve the deproteinization (DP) efficacy of shrimp shell powders (SSP) for preparing chitin, Serratia marcescens B742 mutants were prepared using 2% diethyl sulfate (DES), UV-irradiation, and/or microwave heating treatments. Both single-stage and multi-stage mutations were investigated for optimizing S. marcescens B742 mutation conditions. Under the optimized mutation conditions (2%...
Infection with Helicobacter pylori is a major risk factor for the development of gastric cancer, and infection with strains carrying the virulence factor CagA significantly increases this risk. To investigate the mechanisms by which CagA promotes carcinogenesis, we generated transgenic zebrafish expressing CagA ubiquitously or in the anterior intestine. Transgenic...
The putative methyltransferase LaeA is a global regulator that affects the expression of multiple secondary metabolite gene clusters in several fungi, and it can modify heterochromatin structure in Aspergillus nidulans. We have recently shown that the LaeA ortholog of Trichoderma reesei (LAE1), a fungus that is an industrial producer of...
Prior studies of modem scientific internationalism have been written primarily from
the point of view of scientists, with little regard to the influence of the state. This
study examines the state's role in international scientific relations. States sometimes
encouraged scientific internationalism; in the mid-twentieth century,t hey often
sought to restrict...
Paleoclimate records from glacial Indian and Pacific oceans sediments document millennial-scale fluctuations of subsurface dissolved oxygen levels and denitrification coherent with North Atlantic temperature oscillations. Yet the mechanism of this teleconnection between the remote ocean basins remains elusive. Here we present model simulations of the oxygen and nitrogen cycles that...
Paleoclimate records from glacial Indian and Pacific oceans sediments document millennial-scale fluctuations of subsurface dissolved oxygen levels and denitrification coherent with North Atlantic temperature oscillations. Yet the mechanism of this teleconnection between the remote ocean basins remains elusive. Here we present model simulations of the oxygen and nitrogen cycles that...
A computer simulation program, Controlled Atmosphere Simulation (CAS), was written in Microsoft Visual Basic 3.0, Professional Edition to evaluate energy use by three type of atmosphere generators used in fruit storage warehouses. The program consists of pulldown time and energy use models for a membrane air separator, an ammonia fractionating...
Biogenic opal, organic carbon, organic matter stable isotope, and trace metal data from
a well-dated, high-resolution jumbo piston core (EW0408–85JC; 59° 33.3′N, 144° 9.21′W,
682 m water depth) recovered from the northern Gulf of Alaska continental slope reveal
changes in productivity and nutrient utilization over the last 17,000 years. Maximum...
Turbidite deposition along slope and trench settings is evaluated for the Cascadia and Sumatra-Andaman subduction zones. Source proximity, basin effects, turbidity current flow path, temporal and spatial earthquake rupture, hydrodynamics, and topography all likely play roles in the deposition of the turbidites as evidenced by the vertical structure of the...
Three-dimensional laser scanning has revolutionized spatial data acquisition and can be completed from a variety of platforms including airborne (ALS), mobile (MLS), and static terrestrial (TLS) laser scanning. MLS is a rapidly evolving technology that provides increases in efficiency and safety over static TLS, while still providing similar levels of...
The Last Interglacial (LIG) represents an invaluable case study to investigate the response of components of the Earth system to global warming. However, the scarcity of absolute age constraints in most archives leads to extensive use of various stratigraphic alignments to different reference chronologies. This feature sets limitations to the...
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Academy, Clinicilor 5, PO Box 58, 400006 Cluj-Napoca, Romania.
r Ltd. This is an open access article
The goal of this study was to optimize a through-boring pattern that will provide adequate preservative penetration while minimizing the reduction in overall pole bending strength. Hole spacing was developed using longitudinal and transverse chemical penetration data from previous studies. Finite element analysis was used as a preliminary assessment tool...
In the tropics, widespread deforestation and conversion of primary forests to agricultural and pasture lands has resulted in losses of composition, structure, and functions of forest landscapes. Deforestation in the tropics is typically preformed via slash-and-burn practices; the byproducts from combustion have been identified as the second-highest form of anthropogenically...
The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
The literature on first-generation South Asian American (SAA) mental health is limited despite the increased focus of studies on help-seeking behaviors and subjective well-being over the past decade. Therefore, we designed a web-based survey seeking to address two research questions. Research Question 1 informed Study 1 of this dissertation project:...
Advances in forest carbon mapping have the potential
to greatly reduce uncertainties in the global carbon
budget and to facilitate effective emissions mitigation strategies
such as REDDC (Reducing Emissions from Deforestation
and Forest Degradation). Though broad-scale mapping
is based primarily on remote sensing data, the accuracy of
resulting forest carbon...
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Botany and Plant Physiology, University of Buea, PO Box 63, Buea, Cameroon
16Department of Biology
Mild mutations in BRCA2 (FANCD1) cause Fanconi anemia (FA) when homozygous, while severe mutations cause common cancers including breast, ovarian, and prostate cancers when heterozygous. Here we report a zebrafish brca2 insertional mutant that shares phenotypes with human patients and identifies a novel brca2 function in oogenesis. Experiments showed that...
Subduction zone earthquake and tsunami hazards affect tens of millions worldwide and the recurrence of these disasters can be evaluated with paleoseismic techniques, because earthquake cycles (and their supercycles) typically span many millennia. In these three chapters, I discuss a suite of analyses I use to evaluate the sedimentary record...