Metal oxide nanocrystals have attracted significant interests due to their unique chemical, physical, and electrical properties which depend on their size and structure. In this study, a continuous flow microreactor system was employed to synthesize metal oxide nanocrystals in aqueous solution. Assembly of nanocrystals is considered one of the most...
ZnO nanofilms with four distinctly different morphologies were fabricated by adjusting physical parameters including the flow rate of the solution and rpm of the rotating disk in the continuous flow mircroreactor system while keeping the same chemical precursors, precursor solution concentration, and reaction temperature. Controlled reactive species including colloidal ZnO...
Sintering of nanoparticle inks over large area-substrates is a key enabler for scalable fabrication of patterned and continuous films, with multiple emerging applications. The high speed and ambient condition operation of photonic sintering has elicited significant interest for this purpose. In this work, we experimentally characterize the temperature evolution and...
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nature of densification in photonic
sintering of nanoparticles
William Macneill, Chang-HoChoi, Chih
Compared to conventional amorphous silicon (a-Si) TFTs, amorphous metal oxide TFTs have superior device performance such as
higher mobility, better sub-threshold swing, and lower off-state current. Amorphous metal oxide TFTs have an additional advantage
on the device uniformity due to the lack of grain boundary issues in the poly-Si TFTs....
Assembly of nanocrystals is considered one of the most promising approaches to design nano-, microstructures, and complex mesoscopic architectures. A variety of strategies to induce nanocrystal assembly have been reported, including directed assembly methods that apply external forces to fabricate assembled structures. In this study ZnO nanocrystals were synthesized in...
Sintering of nanoparticle inks over large area-substrates is a key enabler for scalable fabrication of patterned and continuous films, with multiple emerging applications. The high speed and ambient condition operation of photonic sintering has elicited significant interest for this purpose. In this work, we experimentally characterize the temperature evolution and...
Sintering of nanoparticle inks over large area-substrates is a key enabler for scalable fabrication of patterned and continuous films, with multiple emerging applications. The high speed and ambient condition operation of photonic sintering has elicited significant interest for this purpose. In this work, we experimentally characterize the temperature evolution and...
This objective of this study is to investigate the capability of nanostructured surfaces on dissipating heat flux by performing pool boiling and convective flow boiling. The generation of ultra-high heat flux from high performance electric devices has motivated a number of investigations related to advanced heat transfer especially in two-phase...
Bubble nucleation control, growth and departure dynamics is important in understanding boiling phenomena and enhancing nucleate boiling heat transfer performance. We report a novel bi-functional heterogeneous surface structure that is capable of tuning bubble nucleation, growth and departure dynamics. For the fabrication of the surface, hydrophobic polymer dot arrays are...
Hydrogel polymers are a novel class of hydrophilic materials that have large application areas in both the industrial and medical fields. Carboxymethyl cellulose (CMC) has received attention as a hydrogel polymer. Methods to modify the mechanical properties of gels and films made from CMC are of interest in our lab...
PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
The need to develop a shorter life cycle wheat cultivar which
would be more adapted to multiple cropping systems prompted this
study. Thus the following information was obtained.
Greatest variations in developmental patterns were found in the
stem elongation, booting, inflorescence emergence and anthesis for
five winter and five spring...
The multimedia capabilities of computers have recently become the focus of computer developers due to the increasing demand for advanced computer graphics and new media capabilities, such as video conferencing, 3-D visualization, and animation. To support these multimedia capabilities, specialized graphics hardware, such as MPEG encoding/decoding card, 3-D graphics card,...
An active object system is a transition-based object-oriented system suitable for the design of various concurrent systems. An AOS consists of a collection of interacting objects, where the behavior of each object is determined by the transition statements provided in the class of that object. A transition statement is a...
This dissertation focuses on a central question for six countries in Asia: what factors affect environmentalism? Numerous studies have proposed mixed theoretical explanations for the relationship between diverse values and beliefs regarding environmentalism. Although these diverse studies propose theories for the fast-growing and multifaceted environmentalism in Asia, here it is...
The overriding goal of this study was to provide first order estimates of dilution and tidal flushing of waste discharges released hypothetically into various Oregon estuaries during critical low flows and tides. Causal relationships between discharged wastes and subsequent estuarine response were studied. Various approaches to determine the assimilative capacity...
The purpose of this study was to examine the choice of housing
of Asian graduate students living in off-campus housing and to identify
the relationship between present housing satisfaction and housing
expenditures.
The data were collected from Asian graduate students living in
off-campus housing at Oregon State University. Questionnaires designed...
The nature of inheritance and possible associations for traits
influencing earliness and grain yield were investigated using a four
parent diallel of winter and spring wheat cultivars.
More genetic variability was observed for the traits measured in
segregating populations resulting from crosses between winter and spring
type wheats in contrast...
The Eastern California Shear Zone (ECSZ) is a broad zone of dextral shear inboard of the North American - Pacific plate boundary. Despite decades of study, the significance of a mismatch between geodetic velocities and geologic fault slip rates across the ECSZ remains incompletely understood. Geodetically determined interseismic strain across...
Black stain root disease (BSRD) is a vascular wilt disease of conifers caused by three varieties of the native, insect-vectored fungal pathogen, Leptographium wageneri (L. wageneri var. wageneri, L. wageneri var. ponderosum, and L. wageneri var. pseudotsugae). Although morphological, physiological, and ecological characteristics differ among the three varieties of L....
This study was concerned with the flow of a magnetic self-propelled
ferrohydrodynamic fluid in a horizontal circular tube subjected
to axially varying temperature and magnetic field. The first
phase of the study involved the analytical solution to the governing
equations for the velocity and temperature profiles within the fully
developed...
The persistent underrepresentation and marginalization of women of color in the disciplines of science, technology, engineering, and mathematics (STEM) are well-documented. However, much of the existing literature takes an “either/or” approach, focusing solely on the experiences of either “women” or “minorities” in STEM, without adequately examining the unique experiences of...
Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
The role of gold nanoparticles supported on ZnO in photocatalytic activity for dye degradation
was investigated. To do this, gold nanoparticles supported on ZnO (Au-ZnO) were prepared using a
simple co-precipitation method. The prepared nanocatalyst was characterized by high resolution
transmission electron microscopy, X-ray diffraction, temperature programmed reduction, X-ray
photoelectron...
This study explores how a star CEO winning a prestigious award and prior firm performance relative to competitive aspirations, defined as the performance of industry peers, influence competitor CEOs’ risk-taking. Using a difference-in-differences methodology, we find that when a star CEO wins a prominent award, competitor CEOs increase their risk-taking....
The consumption of cruciferous vegetables is associated with several health benefits, including cancer prevention. Many of these benefits are attributed to the phytochemical, sulforaphane (SFN), which is derived from cruciferous vegetables such as broccoli and broccoli sprouts. These vegetables contain glucoraphanin (GFN), SFN’s precursor, which is converted to SFN by...
Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Purpose:
The xanthophyll carotenoids lutein and zeaxanthin are concentrated in the macula lutea of the retina. It is thought that the two plant pigments may play a role in preventing the development of age-related macular degeneration (AMD). Exposure to damaging light plays a role in retinal deterioration and AMD. The...
The reaction conditions for the synthesis of Cu-BTC (BTC = benzene-1,3,5-tricarboxylic acid) were elucidated using a continuous-flow microreactor-assisted solvothermal system to achieve crystal size and phase control. A high-rate synthesis of Cu-BTC metal-organic frameworks with BET surface area of more than 1600 m²/g (Langmuir surface area of more than 2000...
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., Chang, C. H., Wannenmacher, N., Thallapally,
P. K., & Ahn, H. G. (2013). High-rate synthesis of Cu-BTC
Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted interest in the chemo-preventative action of dietary components such as soy and green tea commonly found in Asian diets, such as soy and green tea. Studies have suggested that soy isoflavones and green tea...
Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
CAPA and pyrokinin (PK) neuropeptides are produced from two different genes, capa and pyrokinin, respectively. In this study, we identified and characterized the capa and pyrokinin genes from the brown marmorated stink bug, Halyomorpha halys (Hemiptera). The capa gene encodes two CAPA-PVK (periviscerokinin) peptides (DAGLFPFPRVamide and EQ-LIPFPRVamide) and one CAPA-DH...
Enhanced pool boiling critical heat fluxes (CHF) at reduced wall superheat on nanostructured
substrates are reported. Nanostructured surfaces were realized using a low temperature process,
microreactor-assisted-nanomaterial-deposition. Using this technique we deposited ZnO nanostructures
on Al and Cu substrates. We observed pool boiling CHF of 82.5 W/cm2 with water as
fluid...
The connectivity among straits of the northwest Pacific marginal seas is investigated with a primitive-equation ocean circulation model simulated for 10 years from 1994 to 2003. Over the simulation interval the temporal and spatial means and variations of the model sea surface temperature are comparable to those of the satellite...
Oomycetes are some of the most devastating pathogens, causing upwards of billions of dollars of damage each year to plants. They also diminish ecological diversity and health through the destruction of trees and shrubs. The genome sequence of Pseudoperonospora cubensis, an obligate plant pathogen and causative agent of downy mildew...
DNA four-way junctions (also known as Holliday junctions) are the primary structural intermediate during recombination, an important process responsible for biological evolution and maintenance of genomes. These junctions arise from the assembly of four nucleic acid strands to produce double-helical regions extending from a central point. Although much progress has...
The (nonlinear) response behavior of a piecewise-linear system is investigated under
both deterministic and stochastic excitations in this study. A semi-analytical procedure is
developed to predict the system behavior by evaluating the joint probability density functions
of the Fokker-Planck equations of the stochastic piecewise-linear system under random
excitations via a...
Hand-held devices are among the most successful consumer electronics in modern society. Behind these successful devices, lies a key analog design technique that involves high-performance analog-to-digital conversion combined with very low power consumption. This dissertation presents two different approaches to achieving high power efficiency from a two-step pipelined architecture, which...
Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Boiling heat transfer is studied for its ability to dissipate high fluxes and achieve heat transfer coefficients two orders of magnitude greater than single-phase heat transfer systems. Heater surface enhancement with increased surface area, varied geometry, wettability contrast and micro/nano-structures can further enhance boiling heat transfer performance through bubble nucleation...
Transparent and electrically conductive metal oxide nanoparticles have attracted much attention, and can be used to improve the performance of solar cells, transparent electrode materials, and gas sensor technology. Specifically, indium tin oxide (ITO) nanocrystals (NCs) are potentially useful nanomaterials, having technological applications in enhanced sensitivity of optical spectroscopy due...
Inkjet-printed p-type copper(I) iodide-based TFTs were successfully fabricated. As-printed copper(I) halide semiconductor films, such as CuI, CuBrI, and CuClI, were used as p-type active channel layers for TFTs. The entire process of the TFTs fabrication was maintained under 150 °C, which is compatible with flexible plastic substrates and transparent glass...
A unique microreactor-assisted nanomaterial synthesis and printing process was studied for the fabrication of patterned metal oxide nanostructured thin films. The process uses a continuous flow microreactor to control and generate a reactive chemical flux that was transported to a patterned microfluidic channel. The microreactor-assisted nanomaterial synthesis process can generate...
There is an emerging interest in developing wearable electronics as a platform, which
provides the flexibility of a wearable while maintaining its promising functionality as smart textiles. Metal-halide semiconductors are attractive materials with tunable optical and electrical properties. Researchers have widely studied and applied it for advanced
photonics and optoelectronic...
Anti-reflective coatings are applied to substrates to increase the transmittance of light in the visible range of wavelength 400 – 800 nm through the substrate by changing the refractive index at the surface and directing more light through the substrate rather than being reflected away. This project investigated the possibility...
Digital printing techniques offer several advantages in manufacturing electronics such as direct writing of materials, reduction of chemical waste, and scalability. In particular, printing can significantly simplify manufacturing processes by directly defining the channel area, the gate, and the source and drain contacts, allowing for lower costs and higher throughput...
The continuous development of higher performing battery materials has emerged in parallel with the development of new manufacturing processes. Nanomaterials are one solution to addressing the cycling and performance challenges that limit existing battery cells. However, many of the methods used today for nanomaterial synthesis are high temperature batch methods...
The various solution-based processes, spin coating, inkjet printing, microreactor assisted nanoparticle deposition (MANDTM) and spin-successive ionic layer absorption and reaction (Spin-SILAR) were used to demonstrate thin film electronics and anti-reflective coatings. Several aspects of thin film transistors (TFTs) were tested including a range of temperatures, annealing atmosphere, and deposition methods....
To assess the conversion and embedment of yttrium nitrate to yttrium oxide using selective laser melting, a thermodynamic approach for laser power and scan speed predictions on surface temperature, recoil pressure, and resulting track morphology window are employed. Inkjet printing is used to deposit the liquid film of yttrium nitrate...
The primary goal of this thesis is to synthesize titanium dioxide nanorods using a continuous flow microreactor. Titania powder, one of the most important particulate materials is used for many purposes owing to its excellent optical properties of a high refractive index leading to high hiding power and whiteness of...
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Chih-Hung Chang
The primary goal of this thesis is to synthesize titanium dioxide nanorods
The primary goal of this thesis is to fabricate a magnetic film between the coplanar transmitted stripline for crosstalk suppression. Crosstalk is caused from undesired inductive and capacitive coupling of signals between two conductors. The effective crosstalk suppression results from the inductive coupling of circuit elements through the lossy properties...
Photoluminescence (PL) materials have attracted a lot of attention in last several decades. Recently PL materials, which can convert low-efficiency Ultraviolet (UV) or Infrared (IR) light to high-efficiency visible light, have been widely applied in the research of improving conversion efficiency of solar cell. As one of the most common...
CuInGaSe₂ (CIGS), a promising thin film solar cell material, has gained lots of
attention in decades due to its high energy conversion efficiency and potential lower
manufacture cost over conventional Si solar cells. As a cheaper processing method
compared to vacuum-based techniques, solution-based deposition has been
successfully applied to fabricate...
Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
The focus of this study is to develop a general and low-cost solution-based
process to fabricate micro- and nano-structured semiconductors that are suitable
for electronics. This process uses simple metal halide precursors dissolved in a
solvent (organic or aqueous) and is capable of forming uniform and continuous
thin films via...
As a group of promising semiconductor materials, metal chalcogenides in thin film form have been widely used in electronics and optoelectronics applications, such as solar cell devices and photon sensors. Unfortunately, the film size and product throughput are limited by the current vacuum-based thin film deposition techniques. Solution-based thin film...
Zinc Sulfide (ZnS) thin film, with a wide band gap, has been used for many applications, such as buffer layer for CIGS solar cells, light emitting diodes and thin film electroluminescent devices.
In this work, ZnS thin films were prepared using two different deposition processes. In the first method, ZnS...
This paper presents a new mechanical design of an anthropomorphic robot hand. The hand is designed such that it is adaptive, backdrivable, modularized to provide both dexterity and robustness. The hand has 18 joints, 14 degrees of freedom, and a new joint mechanism called an active DIP-PIP joint for the...
The continuous microreactor-assisted solution deposition (MASD) process was used for the deposition of CdS thin films on fluorine-doped tin oxide (FTO) glass. The MASD system, including a T-junction micromixer and a microchannel heat exchanger is capable of isolating the homogeneous particle precipitation from the heterogeneous surface reaction. The results show...
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Chih-Hung Chang
The continuous microreactor-assisted solution deposition (MASD) process
was
Recent advances in nanocrystalline materials production are expected to impact the development of next generation low-cost and/or high efficiency solar cells. For example, semiconductor nanocrystal inks are used to lower the fabrication cost of the absorber layers of the solar cells. In addition, some quantum confined nanocrystals display electron-hole pair...
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Chih-Hung Chang
Recent advances in nanocrystalline materials production are expected to
The significance of the various carbon cycling pathways in driving the sharp sulfate methane transition (SMTZ) observed at many locations on continental margins is still a topic of debate. Unraveling these processes is important to our understanding of the carbon cycle in general and to evaluate whether the location of...
Copper sulfides (Cu[subscript x]S) are compound semiconductor materials that exhibit considerable optical and electrical properties varying significantly as a function of the composition. Copper sulfide thin films can be used in many applications, such as solar control coatings, solar cells, photothermal conversion of solar energy, electroconductive coatings, and microwave shielding...
To become a competitor for fossil fuels such as coal, solar installations will need to be produced and installed at a price equal to or below grid parity. This price can be approached by either reducing the overall system cost or increasing system efficiency. The focus of this paper is...
We investigate the response of multi-layer epitaxial graphene and chemical vapor deposition (CVD)-grown single-layer graphene to strong terahertz (THz) fields. Contrary to theoretical predictions of strong nonlinear response, the transmitted fields exhibit no harmonic generation, indicating that the nonlinear response is limited by fast electron thermalization due to carrier-carrier scattering....
Platelet-rich plasma (PRP) has been applied as a hemostatic agent since the 1970s, and a potent source of autologous growth factors since the 1990s. PRP is rich in growth factors such as platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), fibroblast growth factor (FGF)...
Continuous process scale-down and emerging markets for low-power/low-voltage mobile systems call for low-voltage analog integrated circuits. Switched-capacitor circuits are the building blocks for analog signal processing and will encounter severe overdrive problems when operating at low-voltage conditions. There are several well-known techniques to bypass the problem. These approaches include: (1)...
The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
This study was undertaken to analyze the opinions of
elementary school teachers in Korea about actual and desired
levels of computer education and the sources of computer
anxiety, with the object of developing guidelines for
a teacher training program. A survey instrument was developed
and tested to provide basic sample...
We report ultrafast pump-probe spectroscopy examining exciton dynamics in atomically thin MoS2. Spectrally and temporally resolved measurements are performed to investigate the interaction dynamics of two important direct-gap excitons (A and B) and their associated broadening kinetics. The two excitons show strongly correlated interexcitonic dynamic, in which the transient blue-shifted...
Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
As decomposers, fungi are key players in recycling plant material in global carbon cycles. We hypothesized that genomes of early diverging fungi may have inherited pectinases from an ancestral species that had been able to extract nutrients from pectin-containing land plants and their algal allies (Streptophytes). We aimed to infer,...
Schizopora paradoxa KUC8140 is a white rot wood degrader commonly found in Korea. Tolerance to heavy metals and polycyclic aromatic hydrocarbons and dye decolorization activity make this strain a potential candidate for mycoremediation. We report the genome sequence of S. paradoxa KUC8140 containing 44.4 Mbp. Based on ab initio gene...
We show that the transmission of a terahertz (THz) pulse through single-layer graphene is strongly
nonlinear. As the peak electric field of the THz pulse exceeds 50 kV/cm, the graphene becomes
increasingly transparent to the THz radiation. When field strength reaches 800 kV/cm, the increased
transparency corresponds to a two-fold...
The catalytic activity of a monolithic catalyst with nanosized Pt and Au particles on ZnO/Al₂O₃ (Pt-Au/ZnO/Al₂O₃/M) prepared by a wash-coat method was examined, specifically for toluene oxidation. FE-SEM image showed clearly the formation of a ZnO/Al₂O₃ layer on the monolith. Nanosized Pt-Au particles on ZnO/Al₂O₃/M with different sizes could be...
In this work, stainless steel wire cloth (SSWC) for metallic support was thermally treated to increase the adhesive strength of Al₂O₃ by improving superficial roughness. After coating Al₂O₃ on SSWC, Pt particles as a catalytic component were deposited on the Al₂O₃/SSWC. These supports and catalysts were characterized by N₂ gas...
A significant body of research demonstrates that phytochemical intake favorably influences hepatic metabolism via a number of different biological mechanisms. Other research has shown a positive effect of certain phytochemicals on kidney health, specifically in ameliorating symptoms of kidney disease. The current research used three separate studies that tested the...
Metabolic improvements and changes in gene expression were measured in mice fed polyphenol-rich extracts derived from apples and sweet cherries, and the common phytochemicals, quercetin and ellagic acid. Polyphenol-rich extracts were produced by solid phase extraction and column chromatography. Extracts and purified compounds were mixed into a high-fat (HF, 60%...
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess neutral lipids within the parenchymal cells of the liver. The primary etiology is diet-induced and most often exists as a comorbidity with obesity, metabolic syndrome, and/or Type 2 Diabetes. The development of excess liver lipid can be self-limiting...
The effect of cosputtered catalyst on growth and alignment of carbon nanotubes (CNTs) grown by plasma enhanced chemical vapor deposition (PECVD) was investigated. Aligned CNTs were observed using a cosputtered catalytic metal deposited directly on boro-aluminosilicate glass. Catalytic metal alloys were sputtered directly onto the substrate using magnetron sputtering. Deposition...
Aging is a complex process associated with physiological changes in numerous organ systems. In particular, aging of the immune system is characterized by progressive dysregulation of immune responses, resulting in increased susceptibility to infectious diseases, impaired vaccination efficacy, as well as systemic low grade chronic inflammation. Increasing evidence suggest that...
Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Metal Organic Framework (MOF) materials, consisting of metal ions with organic linkers, have a functional cavity structure which can be utilized in applications such as catalyst, micro sensing, and gas absorption. Due to MOF materials' selective gas adsorption property, interest in MOF materials has intensified in the last few years,...
Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. The nonproteinogenic amino acid capreomycidine is the signature residue found in the tuberactinomycin family of antitubercular peptide antibiotics and an important element of the pharmacophore. Recombinant VioG, a single module peptide synthetase from the viomycin gene cluster cloned...
Calcium activated proteases, or calpains, are activated in cardiac muscles under conditions of ischemia/reperfusion and hypoxia. Their activity in skeletal muscle under similar conditions is poorly understood. We tested the hypothesis that hypoxia elevates calpain-mediated proteolysis in isolated glycolytic (extensor digitorum longus, EDL) and oxidative (soleus, SOL) mouse muscles studied...
Endothelial activation with increased expression of cellular adhesion molecules, chemokines and pro-inflammatory cytokines critically contributes to vascular inflammation and the initiation and progression of atherosclerosis. By affecting redox-sensitive cell signaling pathways and transcription factors, redox-active transition metal ions, such as copper and iron, may play an important role in these...
Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...
Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
Acute lymphoblastic leukemia (ALL) encompasses a spectrum of lymphoid progenitors that have undergone malignant transformation and clonal proliferation at various stages of differentiation. Some cases of ALL have been documented to have prenatal origins and in particular neonatal exposure to various environmental pollutants is associated with increased disease risk, including...
Osteoporosis is a common metabolic bone disease, affecting a third of women and a fifth of men over age 65. In the US, annual health care costs associated with osteoporosis are estimated to be over $20 billion. Osteoporosis is associated with increased fracture risk, which has been demonstrated to predict...
Type 2 diabetes mellitus (T2DM) is a disease of multi-complications
affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
Metabolic syndrome (MetS) and abdominal obesity (AbOb) increase the risk of
developing cardiovascular disease and diabetes. Energy restriction (ER), highprotein
(PRO) intake and high-intensity interval training (HIT) can independently
improve MetS and AbOb. However, ER reduces metabolically active lean body
mass (LBM) in addition to body fat (BF). Purpose: To...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
Non-alcoholic fatty liver disease (NAFLD) is defined as excess hepatic lipid accumulation, in the absence of excess alcohol consumption and chronic liver disease. NAFLD can range in severity from simple fatty liver (steatosis) to non-alcoholic steatohepatitis (NASH). NASH is defined as hepatic steatosis with inflammation and hepatic injury and describes...
Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
Epidemiological evidence has demonstrated a reduced risk of prostate cancer associated with cruciferous vegetable intake. Follow-up studies have attributed this protective activity to the metabolic products of glucosinolates, a class of secondary metabolites produced by crucifers. The metabolic products of glucoraphanin and glucobrassicin, sulforaphane and indole-3-carbinol respectively, have been the...
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Prostate Cancer
*Dr. Emily Ho
Oregon State University
BPHS Department
Milam Hall Room #103