First, topological vector spaces are examined from a partial
order structure derived from neighborhood bases of the origin. This
structure is used to produce a minimal vector norm for every
Hausdorff locally convex space.
Then, topological vector spaces are examined to find translation
invariant measures with respect to which functions...
Motion planning is a cornerstone of autonomous robots, enabling robots to safely and efficiently perform tasks such as package delivery, infrastructure inspection, and manipulation. However, as the field of robotics matures, robotic systems are being developed that (1) are challenging to analytically model, (2) require computationally expensive model-based controllers, and...
Many nations that invest in aquaculture and fisheries for improved nutrition and food security are located in areas prone to natural disasters, such as typhoons. While all residents are vulnerable to the effects of disasters, research suggests that women are disproportionately affected at all stages of disaster management: preparedness, response,...
As a major biological model for biomedical research, maintaining healthy
zebrafish (Danio rerio) is imperative for accurate and consistent lab results. This
retrospective study focuses on Pseudoloma neurophilia, a microsporidium, because it is
the most common pathogen found in laboratory zebrafish. An online database maintained
by the Zebrafish International Resource...
The Cantor set is a compact, totally disconnected, perfect
subset of the real line. In this paper it is shown that two non-empty,
compact, totally disconnected, perfect metric spaces are homeomorphic.
Furthermore, a subset of the real line is homeomorphic
to the Cantor set if and only if it is...
The new CMOS folded source-coupled logic (FSCL)
technique intended for mixed-mode integrated circuits has
been designed. It has advantages over conventional CMOS
circuit in terms of reduced current spike, circuit delay,
logic flexibility, and layout density. A simple CPU
implemented in 2 μm CMOS technology with a 5.0 volt supply...
Aging is known to be affected by many factors such as nutrition and exercise, and more studies are needed to understand the mechanisms of aging. Aging in flies shows many similarities with humans; therefore we study mechanisms of aging in flies as a model organism. Studying aging in flies requires...
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increasing population of the elderly within the US. This has created a need to better understand the
Aging is known to be affected by many factors such as nutrition and exercise, and more studies are needed to understand the mechanisms of aging. Aging in flies shows many similarities with humans; therefore we study mechanisms of aging in flies as a model organism. Studying aging in flies requires...
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increasing population of the elderly within the US. This
has created a need to better understand the
Aging is known to be affected by many factors such as nutrition and exercise, and more studies are needed to understand the mechanisms of aging. Aging in flies shows many similarities with humans; therefore we study mechanisms of aging in flies as a model organism. Studying aging in flies requires...
Adequate energy stores are essential for survival, and sophisticated neuroendocrine mechanisms evolved to stimulate foraging in response to nutrient deprivation. Food search behavior is usually investigated in young animals, and it is not known how aging alters this behavior. To address this question in Drosophila melanogaster, we compared the ability...
There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a fundamental role in AD pathogenesis. One of the detrimental...
Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Circadian clocks generate daily rhythms in neuronal, physiological, and metabolic functions. Previous studies in mammals reported daily fluctuations in levels of the major endogenous antioxidant, glutathione (GSH), but the molecular mechanisms that govern such fluctuations remained unknown. To address this question, we used the model species Drosophila, which has a...
Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
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*† Michael FG Murphy,2,4† Kathryn J Bunch,3,4
Susan E Puumala,5 Susan E Carozza,6 Eric J Chow,7 Beth A
Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
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category (kg)
b
Cancer Dataset
a Cases Controls 0.50-1.99 2.00-2.49 2.50-2.99 3.00-3.49 3.50-3.99
Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
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.
a Data was adjusted for sex, period and region of birth. USA data was further adjusted for
Background: High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers. Methods: We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554...
Edible tree nut and peanut industries are important agricultural
industries in the United States. Major tree nuts produced
domestically are almonds, filberts, pecans,and walnuts. The United
States imports and exports some quantities of these tree nuts and
peanuts, but at the same time the U.S. imports cashew, brazil,
pignolia, and...
With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Observations of CO2 were made in the upper troposphere and lower stratosphere in the deep tropics in order to determine the patterns of large-scale vertical transport and age of air in the Tropical Tropopause Layer (TTL). Flights aboard the NASA WB-57F aircraft over Central America and adjacent ocean areas took...
Mixia osmundae (Basidiomycota, Pucciniomycotina) represents a monotypic class containing
an unusual fern pathogen with incompletely understood biology. We sequenced and analyzed
the genome of M. osmundae, focusing on genes that may provide some insight into its
mode of pathogenicity and reproductive biology.
Mixia osmundae has the smallest plant pathogenic basidiomycete...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
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Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
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)
“Control” is amount of metabolite in
complete incubation without GSH.
A significant reduction of
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
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Flavin-Containing Monooxygenase S-Oxygenation of a Series
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
This study investigates a possible structural break in the relationship between the price of Norwegian salmon
exported to the EU and prices of Chilean salmon exported to the US. A structural break is expected in the spring/summer
1997 because restrictions on price and quantum on Norwegian salmon was introduced at...
The Energy Frontier Research Center (EFRC) for
Solid-State Lighting Science (SSLS) is one of 46 EFRCs initiated in
2009 to conduct basic and use-inspired research relevant to energy
technologies. The overarching theme of the SSLS EFRC is the
exploration of energy conversion in tailored photonic structures. In
this article we...
Background:
Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH,...
Type 2 diabetes mellitus (T2DM) is a disease of multi-complications
affecting more than 20 million US adults. Hyperglycemia is the classic clinical feature of diabetes, and uncontrolled hyperglycemia leads to deadly health complications. Thus, control of blood glucose represents a major goal for diabetics. Human and rodent studies revealed another...
This study sought to understand the unique challenges that housing insecurity programs faced during the COVID-19 pandemic. An anonymous Qualtrics survey, containing closed- and open-ended questions, was sent to housing insecurity programs in Benton County, Oregon. Questions focused on how the COVID-19 pandemic affected services and how programs adjusted to...
Grounded in life span theory, this study explored how personal goals (as measured by possible selves) related to depressive symptoms in older adults. Possible selves represent individuals' ideas of what they would like to become (hoped-for selves) and what they are afraid of becoming (feared selves). Possible selves are also...
Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
People are increasingly staring at device screens which emit predominantly blue light. Because LED technology is relatively new, we do not know what effects blue light has on our long-term health. Blue light exposure leads to a dramatic decrease in longevity in Drosophila, thus this study aims to explore possible...
Inheritance of the volatile components in bush snap beans,
O.S.U. 58-110 X 'Romano' cross and reciprocal, was determined
using gas-liquid chromatographic technique with gas-entrainment
on-column trapping. A sample of 10 to 14 pods averaging 5 grams
from a single plant was found to be adequate for F₁, F₂, and backcross...
In a story of his life Les reflects on what he
has gained and what he has lost while seeking success in
the moving and shifting of military and academic life
through homes and schools all over the United States.
He describes himself as between races, languages, and
cultures.
Many natural resources such as water and forests have become more intensively used in recent years. Often, this has made it necessary to reallocate these resources from less to more efficient productive usage. The knowledge of the existing tradeoffs between alternative uses are necessary to make reallocative decisions. However, these...
Networks are a structure common to many disciplines. Research on
networks has taken different forms in domains such as graph theory, sociology,
vascular networks, small-world networks, geomorphology, ecology, evolution and
engineering. Networks may be modeled as non-spatial networks (unvalued
graphs), which contain only topological information, or as spatial networks (valued...
Ankle injuries comprise more than 15% of all sports injuries worldwide. The efficacy of the ankle taping for injury prevention has long been under scrutiny as numerous studies have shown that tape rapidly loses its ability to constrain ankle motion with exercise. Consequently, ankle braces (orthoses) are being used with...
The development of problem-solving behaviors in canines, including persistence, has implications for canine training, welfare, and the human-dog bond. Past research has shown that a variety of factors, including genetics (domestication) and training experience, play a role in a how a canine might behave during a problem-solving task. Less well...
Accelerated weathering (AW) tests have become a requirement for many wood composite products. This project monitored temperature and moisture content of specimens undergoing AW exposure for the following standards: ASTM D3434 (automatic boil test), CSA O112.9 (boil-dry-freeze), and PS2 (Section 7.17, 6-cycle VPS). Each AW procedure was conducted with three...
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Frederick A. Kamke
Accelerated weathering (AW) tests have become a requirement for many
The pyrrolizidine alkaloids (PAs) and ergot alkaloids are known natural toxicants found in livestock forage. These alkaloids contribute to large economic losses in livestock throughout the world. An understanding of the mechanisms of toxicity and development of better diagnostic tools for better management practices was investigated. Variability exists in the...
Type-2 diabetes (T2D) has become a pandemic. The main impairment in T2D is skeletal muscle insulin resistance (IR) and is often associated with obesity. Despite decades of study, the mechanisms of IR have not been fully resolved. Evidence has implicated mitochondrial dysfunction as a potential cause and/or consequence of IR....
The focus of this research was to gain an understanding of physical activity in elementary school-aged children with mental retardation (MR). The primary purpose of the first study was to investigate physical activity levels of children with and without MR in both school and out of school environments. The secondary...
Renewable energy, particularly wind power, has increased dramatically over the past two decades. In the Pacific Northwest, the power system has accommodated a large amount of new wind power. The variability of wind power has introduced many challenges, requiring additional reserve generation to be available to maintain system stability. The...
Hawaiian streams are valued for environmental, cultural, and aesthetic
qualities. Windward streams in East Maui, Hawaii are diverted to irrigate crops in
central portions of the island. Diversions typically remove 100% of the base flow and
leave downstream reaches dry most of the year. Ground water seeps and springs
contribute...
The aim of the present project was to quantify and compare differences in impact performance and damping effectiveness among various off-road bicycle suspension systems. Two experiments were conducted to compare suspensions. Fork impact performance was tested by measuring peak antero-posterior braking forces and impulses during impact with bumps of 6-...
Five unique but related studies were conducted at the Oregon State University Dairy
Wetland Treatment System (OSUDWTS), Corvallis, OR. The research site consisted of
six parallel wetland cells, which were built in 1992 and began receiving concentrated dairy
wastewater in the fall of 1993. Hydrologic, hydraulic, and water quality data...
Structural engineered wood manufacturers need a quantitative measurement technique to determine the ratio of wood to adhesive failure in their shear specimens. Visual estimation of percent wood failure has long stood as an extremely subjective quality control approach according to ASTM D5266 – Standard Practice for Estimating the Percentage of...
While robotic systems may have once been relegated to structured environments and automation style tasks, in recent years these boundaries have begun to erode. As robots begin to operate in largely unstructured environments, it becomes more difficult for them to effectively interpret their surroundings. As sensor technology improves, the amount...
A regime-switching model for market integration study is extended to incorporate dynamic trade flow information and risk perceptions based on an expected utility framework. An application of the extended model to the US-China soybean markets analysis shows that: One, the positive arbitrage rent uncounted-for in the extended model has been...
For Pacific salmon, the evolution of local adaptations depends upon the species' propensity to return, or "home", to natal streams at time of reproduction. Pacific salmon use olfactory cues to guide homing behavior, yet little is known about the genetics of olfaction in salmon. In this study, I use putatively...
The effectiveness of robot autonomy is governed by the ability to make decisions based on online sensor measurements and a prior belief of the environment. Uncertainty in the environment introduces challenges to robotic decision making. This thesis address two key robot decision making problems: exploration and navigation. The robotic exploration...
Acetaldehyde is known to be responsible for the green
or yogurt-like flavor defect of lactic cultures. This study was undertaken
to extend the knowledge of acetaldehyde production and utilization
by microorganisms normally found in mixed-strain butter cultures.
It is anticipated that the resulting information will contribute
to a more thorough...
Semi-insulating, powder samples of Cadmium Telluride (CdTe) have been studied using ¹¹¹In Time Differential Perturbed Angular Correlation (PAC) Spectroscopy. The samples have been lightly doped (~10¹² cm⁻³) with ¹¹¹In atoms, which occupy well-defined metal (Cd) lattice sites and act as probes of the local environment. These substitutional donors form a...
Amines formed by biosynthesis in germinated barley have been
suggested as precursors for N-nitrosodimethylamine (NDMA) in barley
malt dried by direct-fired kilning. This hypothesis was verified by
germinating raw barley and exposing the resulting malt roots and
clean malt to nitrous acid. Quantitation of the NDMA formed indicated
that malt...
The study was conducted to obtain information concerning the factors affecting the differences in the marginal propensities to consume of farm and nonfarm families observed by Friedman and Lee
and Phillips. As a first step a theoretical framework was developed which indicated the factors affecting the marginal propensity to consume....
In 1996, China started to increase its annual soybean imports at a tremendously high speed. It has become one of the most important soybean import markets for the world's largest soybean producers: the United States, Brazil and Argentina. In the meantime, the Dalian Commodity Exchange (DCE), a Chinese soybean futures...
Little, if any, quantifications have been made on the contribution of the vertebral column during jumping in quadrupedal mammals. Previous studies of jumpers have focused on the morphological and physiological specializations of the hindlimbs. In this study, such specialization was measured during the supramaximal jumps of the Pacific jumping mouse...
Substantial scientific investment has been directed towards understanding factors that influence distribution patterns and animals' remarkable ability for precise orientation and navigation, yet fundamental gaps in our knowledge remain. In my dissertation, I applied emerging genetic technologies to conduct a top-down and bottom-up investigation of animal movement and cue perception....
Winegrapes are an important crop for Oregon agriculture, ranking amongst the top ten agricultural commodities based on farmgate value. The most widely planted winegrape cultivar in the state is ‘Pinot noir’ (Vitis vinifera L.), and the majority of acreage is produced in the Willamette Valley. Production of quality ‘Pinot noir’...
The purpose of this study was to evaluate the impact sediment has on the survival of
bacteria in a typical rangeland stream. This information is an important component in
determining a time integrated prediction of bacterial numbers in the stream sediment and
overlying water. Bacterial survival in stream is a...
Over two million people experience homelessness in the United States, but homeless people are often marginalized by invisibility and stigmas surrounding poverty within their local communities. This research seeks to amplify the voices of Corvallis area homeless women as a means to understand their everyday lived experiences. Six women residing...
Perturbed angular correlation (PAC) spectra of fully yttria-stabilized (cubic) zirconia with Y₂0₃ contents of 35.4 wt. %, 27.8 wt. %, and 16.9 wt. %, respectively, were measured using the isotope ¹⁸¹Ta as probe nucleus. PAC spectra in cubic zirconia are characterized by a wide frequency distribution due to contributions of...
Population genetic techniques are now preeminent in differentiating wild populations. Natural resource managers rely on them in their efforts to restore viable populations of fish and wildlife. Overfishing adversely impacted Yelloweye Rockfish (Sebastes ruberrimus) on the U.S. West Coast in the late 20th century. Management actions included shutting down the...
The objective of this dissertation was to understand the physical mechanisms affecting inversion events in a complex forested mountain landscape. This work was motivated by the long-term studies of climate at the Andrews Forest, short-term studies of vertical temperature, light, wind, and moisture gradient in old-growth trees, and interest in...
State and federal aid payments to local governments have grown explosively over the last fifteen years. One reason for this growth is that the donor governments can alter a local government's budget choices through grants. Grants have not remedied social problems, however, because the local governments' responses to grants were...
Proper immune function is indispensable, as failure to mount an immune response against a pathogen can lead to serious complications or even death. T cells act by enhancing the activation of phagocytic cells as well as the activation of B cells. Their widespread influence on an immune response makes optimal...
Engineering education research has led to a greater understanding of the gap in preparedness of students for the engineering industry. Multiple studies comparing the workplace and academic contexts and the participants in those contexts (i.e., students, faculty, and engineering practitioners) have emphasized similarities and differences between the two contexts by...
Perturbed angular correlation (PAC) spectroscopy of dilute zirconia alloys
and YBa₂Cu₃0₇₋x, ceramic superconductors at elevated temperature have been
measured using ¹¹¹Cd as the probe.
The oxygen vacancy concentration in the zirconia samples was controlled by
doping with yttrium or indium, which introduce vacancies, or with niobium, which
removes vacancies. A...