Index Catalog // ScholarsArchive@OSU

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Creator:: Snow, Erika
Abstract:: Respiratory illnesses caused by both viral and bacterial infection are serious issues for global healthcare providers. With the emergence of new, drug-resistant forms of these diseases, innovative drugs and treatment therapies are needed. M tuberculosis is an infection that affects a large portion of the world’s population each year. Aerosol...
Resource Type:: Presentation and Undergraduate Thesis

Comparing the Ovarian Expression of Sperm Acrosome Associated 3 Protein in Young and Adult Queens

Creator:: Ramsey, Ann M.
Abstract:: The purpose of this thesis was to quantify sperm acrosome associated 3 (SPACA3) protein expression in the ovaries of young (3.0±0.9 months, n=11) and adult (10.4±2.8 months, n=11) queens. It was hypothesized that SPACA3 expression would not differ between age groups. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded feline ovarian sections...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Luiz Bermudez, Committee Member, representing Veterinary Sciences

Cardiovascular Medications and Overall Survival in Lung Cancer Patients: A Systematic Review

Creator:: Du, Catherine
Abstract:: Lung cancer is one of the leading causes of death in the United States. While 90% of lung cancer is due to tobacco smoking, the next major risk factor is pre-existing disease. Cardiovascular disease is reported in 23% of patients diagnosed with lung cancer. A systematic review was conducted to...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Luiz Bermudez, Committee Member, representing Department of Microbiology

Mycobacterium tuberculosis Selective Adenosine Kinase Nucleoside Polymers for Inhalation Therapy

Creator:: Snow, Erika
Abstract:: Respiratory illnesses caused by both viral and bacterial infection are serious issues for global healthcare providers. With the emergence of new, drug-resistant forms of these diseases, innovative drugs and treatment therapies are needed. M tuberculosis is an infection that affects a large portion of the world’s population each year. Aerosol...
Resource Type:: Honors College Thesis
Full Text:: , representing Department of Biomedical Sciences Luiz Bermudez, Committee Member, representing

Identification of Mycobacterium smegmatis Surface Proteins for Stimulation of Anti-Mycobacterial Killing Activity of Macrophages

Creator:: Islam, Sabrina
Abstract:: Mycobacterium avium subspecies hominissuis (M. avium) is a ubiquitous, acid-fast organism found in water and soil. This opportunistic pathogen is a common causative of pulmonary diseases in immunocompromised individuals and prevalent infection in HIV/AIDS patients. As a primary defense response against infection, immune cells such as macrophages phagocytize M. avium...
Resource Type:: Masters Thesis
Full Text:: into the future. I am grateful to Dr. Luiz Bermudez for welcoming me into the program, always being

Flavin-containing monooxygenase : metabolism and toxicity of anti-tuberculosis drug ethionamide in lung

Creator:: Singh, Priti B.
Abstract:: Multiple drug resistance (MDR) Tuberculosis (TB), leads to increased use of “second-line” drugs; one of the most effective is ethionamide (ETA). ETA is a prodrug metabolized by a mycobacterial flavin-containing monooxygenase (EtaA) as well human flavin-containing monooxygenases (FMOs). Of the five functional FMOs of humans, FMOs 1, 2, and 3...
Resource Type:: Masters Thesis
Full Text:: to thank Dr. Luiz Bermudez for his scientific contributions and guidance that encouraged me to

Systematics of the genus Torrubiella

Creator:: Johnson, Desiree M.
Abstract:: Torrubiella is a genus of entomopathogenic fungi in the Clavicipitaceae (Ascomycota). Species of the genus produce superficial perithecia on a loose mat of hyphae that forms directly on the host. The genus is estimated to contain about 70 species. Torrubiella is hypothesized to be a close relative of Cordyceps because...
Resource Type:: Masters Thesis
Full Text:: persistence. I am grateful to the members of my committee: Aaron Liston, Jeffrey Stone, and Luiz Bermudez

Role of Plc in the germination of Clostridium perfringens food poisoning isolate SM101

Creator:: Bond, Colton B.
Abstract:: Clostridium perfringens is the causative agent of gas gangrene and the 3rd most common cause of type A food borne disease in the United States. Critical to the pathogenicity of C. perfringens is the ability of this bacterium to produce highly resistant, metabolically dormant spores that can resume metabolic function...
Resource Type:: Masters Thesis

Molecular mechanism of germination of Clostridium perfringens spores

Creator:: Paredes-Sabja, Daniel
Abstract:: Clostridium perfringens is the causative agent of a wide variety of diseases in animals and humans. C. perfringens can produce more than 15 toxins. However, individual strains produce a subset of these toxins. Although a small percentage of C. perfringens isolates (mostly belonging to type A) produce C. perfringens enterotoxin...
Resource Type:: Dissertation

Characterization of Sporulation and Germination Genes in Clostridium perfringens

Creator:: Talukdar, Prabhat Kumar
Abstract:: Clostridium perfringens is a Gram-positive, anaerobic, spore-forming bacterium that can produce as many as 17 different toxins and are responsible to cause a wide array of gastrointestinal (GI) and histotoxic diseases in humans and animals. As individual strains produce a subset of these toxins, C. perfringens strains can be classified...
Resource Type:: Dissertation
Full Text:: helps me to overcome difficult times in my research. I also want to thank Dr. Luiz Bermudez, Dr

New Insights into the Molecular Mechanism of Clostridium perfringens Spore Germination

Creator:: Banawas, Saeed S.
Abstract:: C. perfringens is a spore-forming, gram-positive, anaerobic pathogenic bacterium capable of causing a wide variety of diseases in both humans and animals. However, the two most common illnesses in humans are C. perfringens type A food poisoning (FP) and non-food-borne (NFB) gastrointestinal (GI) illnesses. Interestingly, these two major diseases are...
Resource Type:: Dissertation
Full Text:: graduate student. I wish also to thank my thesis committee members, Dr. Daniel Rockey, Dr. Luiz Bermudez

Collaborative Neighborhood-Scale Sustainability Assessment and Planning using the Spatial Optimization for Urban Resource Conservation and Engagement (SOURCE) Tool : Applying the Analytic Hierarchy Process for Spatial Decision Support

Creator:: Gutierrez, Evan Erasmo
Abstract:: A fundamental problem that emerges during the planning of a city or neighborhood is how to prioritize sustainable development criteria and where to focus efforts. Solving this problem is a complex task requiring an integrated approach, which considers environmental, economic, and social criteria, as well as stakeholder preferences. Given the...
Resource Type:: Dissertation

Pseudoloma neurophilia : progression of infection and transmission characteristics of a microsporidian parasite in a model vertebrate, Danio rerio

Creator:: Sanders, Justin L.
Abstract:: The microsporidian parasite, Pseudoloma neurophilia, is the most commonly diagnosed infectious disease in laboratory populations of the zebrafish, Danio rerio. Infections by P. neurophilia are generally subclinical, however, they can become acute either incidentally or due to experimental immune suppression. Non-protocol induced variation can confound results in laboratory experiments using...
Resource Type:: Dissertation
Full Text:: . Luiz Bermudez, Kathy O'Reilly, Michelle Steinauer, and Robert Tanguay, for their guidance, advice

Clostridium perfringens spores : inactivation, germination, and formation

Creator:: Udompijitkul, Pathima
Abstract:: The enterotoxin-producing Clostridium perfringens type A isolates are responsible for the third most common foodborne illness in the United States and can also cause non-foodborne human gastrointestinal (GI) diseases such as antibiotic- associated and sporadic diarrheas. Three important factors contribute to the ability of C. perfringens to cause GI diseases,...
Resource Type:: Dissertation
Full Text:: appreciations are for my thesis committee, Dr. Luiz Bermudez, Dr. Dan Rockey, Dr. Alan Bakalinsky, and Dr

Vaccinia virus I7L core protein proteinase

Creator:: Byrd, Chelsea M.
Abstract:: Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Resource Type:: Dissertation
Full Text:: committee members, Dan Arp, Dan Rockey, Walt Ream, and Luiz Bermudez for constructive criticism, freedom

Understanding chlamydial biology through genome sequencing and comparative genomics

Creator:: Jeffrey, Brendan
Abstract:: The human pathogen Chlamydia trachomatis displays different phenotypes between serovars both in vivo and in vitro. The study of chlamydial biology has been hampered by the lack of a tractable genetic system. Here, chlamydial isolates with known phenotypes as well as strains generated though recombination were fully sequenced to address...
Resource Type:: Dissertation

Molecular characterization of an HIV-1 drug target and antiviral compound development

Creator:: Maselko, Maciej
Abstract:: The Human Immunodeficiency Virus -1 (HIV-1) has been the source of substantial human misery since it was first discovered in the early 1980s. Despite remarkable progress that has been made towards understanding HIV- 1, there is no cure, no vaccine and life-prolonging therapies are beyond the reach of millions in...
Resource Type:: Dissertation

Bacterial pathogens and associated toxins involved in erythrophore cell aggregation

Creator:: Hutchison, Janine R.
Abstract:: Current detection methods for bacterial contamination rely on structure based detection of proteins and nucleic acids. While these methods are easy to use and reliable, they cannot evaluate the toxicity of a sample and the potential to cause disease. Previously, erythrophore cells derived from Betta splendens had been suggested as...
Resource Type:: Dissertation
Full Text:: thank my committee members Dr. Luiz Bermudez, Dr. Mahfuz Sarker, Dr. Martin Schuster, and Dr. Phil

Clostridium perfringens sporulation and gliding motility

Creator:: Huang, I-Hsiu
Abstract:: Clostridium perfringens type A isolates, an anaerobic enterotoxigenic spore forming bacterium, are the third leading cause of food-borne disease in the United States. Factors that contribute to the virulence of C. perfringens include the ability of the bacterium to form heat resistant spores and to produce an enterotoxin (CPE). Although...
Resource Type:: Dissertation
Full Text:: . Also many thanks to my committee members, Dr. Luiz Bermudez, Dr. Claudia Hase, Dr. Emily Ho, Dr. Dan

Analysis of chlamydial and host proteins associated with infection

Creator:: Chu, Hencelyn
Abstract:: Chlamydiae are obligate intracellular bacteria that infect a variety of eukaryotic hosts and affect normal host processes. Within host cells, their developmental cycle takes place inside non-acidified vacuoles termed inclusions. An inclusion membrane composed primarily of secreted chlamydial synthesized proteins called Incs encloses the inclusion. At this location, Incs have...
Resource Type:: Dissertation
Full Text:: , Dr. Luiz Bermudez, Dr. Mahfuz Sarker, Dr. Karen Guillemin, and Dr. Barbara Taylor who all have an

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