Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
In rats, sesame lignans increase plasma γ-tocopherol concentrations and inhibit γ-tocopherol degradation to its metabolite γ-carboxyethylhydroxychroman (γ-CEHC). To test if sesame lignan consumption inhibits γ- tocopherol metabolism in humans, muffins prepared with either corn oil (control) or sesame oil and an equimolar mixture of deuterium labeled d6-α- and d2-γ- tocopheryl...
Consuming cruciferous vegetables such as broccoli sprouts, kale, Brussels sprouts, and bok choy is associated with several health benefits, such as a decreased risk of certain cancers. Cruciferous vegetables contain the glucosinolate, glucoraphanin (GFN). Cutting, chopping or chewing these vegetables releases the enzyme myrosinase, which transforms GFN into sulforaphane (SFN)....
During fall term of 2015 and winter and spring term of 2016 I assisted in research within Dr. Emily Ho’s lab. The project that I assisted in looked at the effects of low zinc status and arsenic exposure in mice. Zinc is an essential micronutrient involved in numerous cellular processes...
Approximately ninety percent of urban Vietnamese households are connected to septic tanks, from which up to three-quarters of the sludge is reported to be dumped into waterways in residential areas. Vietnam has a considerable prevalence of antibiotic misuse and resultant antibiotic-resistant bacteria (ARB) in the human microbiome. Due to the...
Purpose:
The xanthophyll carotenoids lutein and zeaxanthin are concentrated in the macula lutea of the retina. It is thought that the two plant pigments may play a role in preventing the development of age-related macular degeneration (AMD). Exposure to damaging light plays a role in retinal deterioration and AMD. The...
Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
The consumption of cruciferous vegetables is associated with several health benefits, including cancer prevention. Many of these benefits are attributed to the phytochemical, sulforaphane (SFN), which is derived from cruciferous vegetables such as broccoli and broccoli sprouts. These vegetables contain glucoraphanin (GFN), SFN’s precursor, which is converted to SFN by...
Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...
Zinc is an essential mineral that is integral to many proteins and transcription factors that regulate key cellular functions. The normal prostate accumulates high concentrations of zinc; however, malignant tissues have significantly lower zinc levels. This unique relationship between zinc and the prostate has sparked interest in the role of...
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Emily Ho
Zinc is an essential mineral that is integral to many proteins and transcription
Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted interest in the chemo-preventative action of dietary components such as soy and green tea commonly found in Asian diets, such as soy and green tea. Studies have suggested that soy isoflavones and green tea...
Pancreatic beta cells produce and release insulin, a vital hormone that regulates blood glucose levels, and their dysfunction contributes to the development of diabetes mellitus. Dietary zinc deficiency and exposure to the toxicant inorganic arsenic have both independently been associated with diabetes, although the effects of their combination on pancreatic...
Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
As genome sequencing projects begin to come to completion, the challenge becomes one of determining how to understand the information contained within the DNA. DNA is a polymorphic macromolecule; the A- B- and Z-DNA conformations have been observed by a variety of physical techniques. The magnitude of the energetic differences...
The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
An in vitro study was conducted to investigate the metabolism and distribution of Se⁷⁵-selenite and Se⁷⁵-selenomethionine (SEM) in
chick blood. Se⁷⁵-selenite is taken up by RBC (13% within 20
minutes) and expelled into the plasma to become bound to proteins. In
contrast, Se⁷⁵-SEM showed a more gradual and continuous buildup...
The relative enrichment of skin sebaceous gland lipids with deuterium-labeled α-tocopherol was compared with plasma enrichment to evaluate the delivery of vitamin E to skin. For the first week of this study, each subject consumed a daily dose of deuterated vitamin E (150 mg of an equimolar mixture of RRR-α-[5-(C²H₃)]-(d₃)...
The target fragment production cross sections, angular
distributions, and range distributions have been measured for the
interaction of 12-16 A MeV³² S with ¹⁶⁵Ho. The fragment isobaric
yield distribution and the moving frame angular distributions have
been deduced from the data. Symmetry properties of the moving frame
angular distributions have...