The inhibition of S-aden.osylmethionine: Δ²⁴-sterol methyltransferase
(EC 2.1.1.41) activity by endogenous cellular components has
been studied in vitro. The principal inhibitors were Na⁺ and K⁺; Cs⁺,
NH₄⁺ and Li⁺ were also shown to inhibit the reaction. The inhibition
by potassium cation has been studied, and we have found that energy...
The generation of the methyl group of methionine, and is also involved in thymidylic acid and purine biosynthesis. The understanding of the mechanisms and controls involved in one-carbon metabolism is incomplete, and is complicated by the existence of conjugated folate cofactors containing up to seven glutamic acid residues. The information...
The efficacy of DNA extraction protocols can be highly dependent upon both the type of sample being investigated and the types of downstream
analyses performed. Considering that the use of new bacterial community analysis techniques (e.g., microbiomics, metagenomics) is becoming
more prevalent in the agricultural and environmental sciences and many...
Stein's Pillar area, central Oregon / Aaron C. Waters -- Seismic reflection studies of buried channels off the Columbia River / Joseph W. Berg, Jr., John M. King, and Paul R. Carlson.
Over a 3.5-year period, 4 Rocky Mountain goats (Oreamnos americanus), housed at a single facility, developed clinical disease attributed to infection by Caprine arthritis encephalitis virus (CAEV). Ages ranged from 1 to 10 years. Three of the goats, a 1-year-old female, a 2-year-old male, and a 5-year-old male, had been...
Hmong women in the U.S. have low rates of breast and cervical cancer screening, and the factors that influence screening in this population are not well-understood. This qualitative study explored family and clan influences on Hmong women’s breast and cervical cancer screening attitudes and behavior. We conducted in-depth interviews with...
Background: Considering the pharmacokinetic and pharmacodynamic aspects of different medications, it is plausible that the age of a smoker could affect the half-life of these drugs. The aim of this study was to compare the effectiveness of smoking cessation drugs (nicotine replacement therapy, bupropion, and varenicline) used either in isolation...
There is increasing evidence that aging is affected by biological (circadian) clocks – the internal mechanisms that coordinate daily changes in gene expression, physiological functions and behavior with external day/night cycles. Recent data suggest that disruption of the mammalian circadian clock results in accelerated aging and increased age‐related pathologies such...
A mathematical model of Limiting Dilution Analysis for two limiting
parameters is presented and investigated. Limiting Dilution Analysis is a microbiological
cell assay developed for immunological application. In the given
case we deal with the interaction between B lymphocytes, macrophage derived
factor and T-independent antigens. The state of the art...