The relative bioavailability and pharmacodynamics
of tolbutamide from two different commercially available
tablet products has been evaluated in healthy subjects
in a single dose cross over study. Products were aged
by exposing tablets to 98% relative humidity for 3 days
at ambient temperature which was found to differentially
affect both...
A two-part study was conducted with three poorly water soluble
drugs (phenylbutazone, tolbutamide, theophylline) to develop two new
drug delivery systems based on physical-chemical approaches.
In the first part, tolbutamide and phenylbutazone were made into
solid dispersions with various excipients using a lyophilization
technique. In vitro dissolution studies of these...
Rats given morphine-codeine combinations exhibited significantly
increased hotplate reaction times compared with rats given
an analgesic dose of one agent alone. Genera, species, sex, protein
binding and metabolism were studied as possible implicating factors
for the increased reaction times. Both male and female rats exhibited
increased reaction time, and showed...
The purpose of this study was to monitor coronary responses
occurring in the S-T segment of an electrocardiogram before, during
and after exercise following a "standard" carbohydrate-loading schedule with varied vitamin B-6 supplementation. The study was conducted
using four college-aged males who had been training a minimum of two
years...
Reported here is an investigation to determine if azinphos-methyl (AZM), an
organophosphate insecticide, adducts to hemoglobin, and if so, whether the
hemoglobin adduct could be used as a quantitative marker of occupational AZM
exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin
in erythrocytes forming an...
Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is
found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and
cauliflower. I3C has been shown to have anticarcinogenic activity against many
chemical carcinogens in multiple target organs in animal models. However, the
anticarcinogenic activity of I3C is considered indirect since...
Representing the most common flavonoid consumed in the American diet, the flavanols and their polymeric condensation products, the proanthocyanidins, are regarded as functional ingredients in various beverages, whole and processed foods, herbal remedies and supplements. Their presence in food affects food quality parameters including astringency, bitterness, sourness, sweetness, salivary viscosity,...
Wheat (Triticum aestivum) is one of the world’s major staple food crops, with flour produced from starchy endosperm being used for breads, cakes, noodles and various other wheat-based foods. The unique bread making properties of wheat are primarily attributed to its gluten-forming storage proteins: gliadins and glutenins. This study investigated...
Data were taken, following irradiation exposure to
100r and 300r cumulative dose, on 89 rabbits of three
breeds that vary greatly in body size. Hematological,
intestinal motility, and ear vascularity examinations
were performed. Least square estimates have been obtained and an analysis of variance has been conducted in
order estimate...
Newborn rats exhibit a torporous response to cold stress at 2°C
from which they revive after several hours exposure even though
respiratory, cardiovascular, and muscular movements have ceased.
At less severe temperatures (20 to 25°C) the rats respond with a non-torporous
decrease in metabolic and physiologic activity and a lowering...
In three separate trials rats were fed either a basal diet deficient
in selenium and vitamin E or the same diet supplemented with
one or both of these factors. In addition to these treatments in two
of the trials, ethoxyquin was included to provide adequate lipid antioxidant
protection and to...
In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate) metabolism have demonstrated that at least three ether soluble metabolites are formed in a microsomal system fortified with reduced triphosphopyridine nucleotide (NADPH). One of the metabolites was identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam. The other two metabolites did not possess...
The effects of x-irradiation on quantitative genetic traits was
investigated by comparing the response of irradiated mice to selection
for litter size and 28-day weight with the response to selection
for the same two traits in non-irradiated lines. Irradiated lines
were maintained at three levels of x-irradiation, 25 r, 50...
In vitro studies of Mobam (4-benzo(b)thienyl N-methylcarbamate)
metabolism have demonstrated that at least three ether soluble
metabolites are formed in a microsomal system fortified with reduced
triphosphopyridine nucleotide (NADPH). One of the metabolites was
identical to 4HBT (4-hydroxy benzothiophene), the phenol of Mobam.
The other two metabolites did not possess...
An investigation of Mn uptake by five-day-old excised barley
roots revealed that a metabolically-mediated process was involved.
In short-term experiments, the rate of Mn absorption was comparable
to that of the macronutrient cations. Like other metabolically
absorbed cations, the Mn absorption rate was a direct function of
the ambient concentration...