Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
The analysis of oxidative stress-induced post-translational modifications remains challenging due to the chemical diversity of these modifications, the possibility of the presence of positional isomers and the low stoichiometry of the modified proteins present in a cell or tissue proteome. Alcoholic liver disease (ALD) is a multifactorial disease in which...
Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis
(M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that allow it to
colonize and persist in austere environments, such as residential and commercial water systems. M. avium is also an
opportunistic pathogen...
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dismutase in macrophages and neutrophil survival
Michael McNamara1,4†, Shin-Cheng Tzeng3,4†, Claudia
Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis
(M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that allow it to
colonize and persist in austere environments, such as residential and commercial water systems. M. avium is also an
opportunistic pathogen...
Pathogenic mycobacteria are important agents causing human disease. Mycobacterium avium subsp. hominissuis
(M. avium) is a species of recalcitrant environmental pathogen. The bacterium forms robust biofilms that allow it to
colonize and persist in austere environments, such as residential and commercial water systems. M. avium is also an
opportunistic pathogen...
Bacteriophage S-CRM01 has been isolated from a freshwater strain of Synechococcus and shown to
be present in the upper Klamath River valley in northern California and Oregon. The genome of this
lytic T4-like phage has a 178,563 bp circular genetic map with 297 predicted protein-coding genes
and 33 tRNA genes...
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. 3
Cameron Thrash1, Samuel E. Bennett3, Shin-Cheng Tzeng4 and Claudia S. Maier4 4
1Department of
Bacteriophage S-CRM01 has been isolated from a freshwater strain of Synechococcus and shown to
be present in the upper Klamath River valley in northern California and Oregon. The genome of this
lytic T4-like phage has a 178,563 bp circular genetic map with 297 predicted protein-coding genes
and 33 tRNA genes...
Bacteriophage S-CRM01 has been isolated from a freshwater strain of Synechococcus and shown to
be present in the upper Klamath River valley in northern California and Oregon. The genome of this
lytic T4-like phage has a 178,563 bp circular genetic map with 297 predicted protein-coding genes
and 33 tRNA genes...
The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
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detection and identification
Yury V. Vasil’ev, Shin-Chen Tzeng, Lin Huang and Claudia S. Maier
The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
The ability of salmon plasma protein (SPP) obtained from Chinook salmon at the Klaskanine Fish Hatchery (Astoria, OR) to inhibit protease enzymes found in Pacific whiting (PW) surimi and salmon mince as well as the effect of SPP on the gelation properties of PW surimi under various heating conditions was...
Freshwater cyanobacterial blooms are a nuisance and health threat in the Pacific Northwest. The accepted methods of characterizing these blooms by microscopic cell counts cannot differentiate between toxic and non-toxic strains of the cyanobacterium Microcystis. Also, there is limited understanding of freshwater cyanophage that may control bloom dynamics. In order...
Mycobacterium avium subsp. hominissuis (MAH) is a pervasive environmental bacterium that can cause opportunistic infections in humans. Among the most robust and hardy members of the Mycobacterium genus, M. avium can persist and thrive in a range of challenging environments, including many which place it in direct contact with humans....
Obesity is a major public health problem and is a risk factor for hypertension, diabetes, heart disease and cancer. In addition, the prevalence of obesity appears to be increasing worldwide, making it important to determine the nature and extent of obesity in populations at risk. The aim of this study...
Resistive random access memory (RRAM) is a non-volatile memory technology based on resistive switching in a dielectric or semiconductor sandwiched between two different metals. Also known as memristors, these devices are potential candidates for a next-generation replacement for flash memory. In this thesis, bipolar resistive switching is reported for the...
The high level of parallelism in throughput processors such as GPGPUs has resulted in significantly changed on-chip data traffic behaviors. This demands new research to identify and address the limiting factors of networks-on-chip (NoCs) in the context of throughput processors. In this work, we first quantitatively analyze the performance of...
The metal organic framework, MOF-74(Ni), was synthesized in a continuous flow microwave-assisted reactor obtaining a high space-time yield (~90 g h⁻¹ L⁻¹) and 96.5% conversion of reagents. Separation of the nucleation and growth steps was performed by using uniform and rapid microwave heating to induce nucleation, which allowed a substantial...
The Machine Learning (ML) algorithms are increasingly explored in varies of fields including designing and optimizing computer systems. Recent research, such as optimizing memory/cache prefetching by ML training or predicting traffic pattern in throughput processors, also exhibits a promising future of introducing ML into computer system design and optimization. Throughput...
The genomes of five Cochliobolus heterostrophus strains, two Cochliobolus sativus strains, three additional Cochliobolus species (Cochliobolus victoriae, Cochliobolus carbonum, Cochliobolus miyabeanus), and closely related Setosphaeria turcica were sequenced at the Joint Genome Institute (JGI). The datasets were used to identify SNPs between strains and species, unique genomic regions, core secondary...