Greater degrees of insulin resistance are associated with increased rates of coronary artery disease (CAD) progression. However, the specific behavioral determinants of insulin resistance are not well known in patients with CAD. Although abdominal obesity contributes to insulin resistance, the extent to which abdominal obesity may modify the relationship between...
Abdominal obesity is a part of insulin resistance syndrome that is closely
linked to increased risk of coronary artery disease (CAD). Because fat tissue acts as
an endocrine target and source of hormone production, increased metabolism or
production of chemical messengers in fat tissue may result in metabolic perturbations
that...
Low physical activity levels and high serum C-reactive protein (CRP) levels are risk factors for coronary artery disease (CAD) in both men and women. However, postmenopausal women who take hormone replacement therapy (HRT) may have increased risk of CAD because of HRT-related increases in serum CRP. There are two manuscripts...
The presence of an increased accumulation of intraabdominal fat (IAF) has been linked to dyslipidemia, hyperinsulinemia, and hyperglycemia, which precede the development of type 2 diabetes and coronary artery disease (CAD). It has been shown that IAF begins depostition during childhood. Human studies suggest that regular endurance exercise, that does...
Individuals with Down syndrome (DS) have less atherosclerosis than others with and without mental retardation (MR). Why individuals with DS do not develop atherosclerosis similarly to others is not known. The insulin resistance syndrome (IRS), a common neuroendocrine disorder underlying cardiovascular disease, has not been investigated in adults with DS...
A biographical study of Denison Olmsted, focusing upon his
own Christian world view and its connection with his various
activities in science, supports the view that religion served as a
significant factor in the promotion of science in America during this
time period. Olmsted taught physics, meteorology and astronomy
at...
In 1981, illegal processing of rapeseed oil by a Spanish oil refinery resulted in the mass foodborne illness epidemic known as Toxic Oil Syndrome (TOS). The toxic oil associated with this epidemic was sold in neighborhood markets and by itinerant salesmen as inexpensive olive oil. Ingestion of the toxic oil...
Studies were conducted to determine the effects of cyclopropenoid
fatty acids (CPFA) on the microsomal membrane of livers of rainbow
trout (Salmo gairdneri). Slab and tube gel electrophoresis of
microsomes from trout fed a CPFA diet (CPFA-microsomes) for varying
time periods showed a decrease in the number of protein bands...
Cyclopropenoid fatty acids (CPFA) are unique compounds that
contain a highly strained and reactive cyclopropene ring structure.
These compounds have been shown to cause a number of toxic effects
in a variety of animals. Rainbow trout (Salmo gairdneri) have
proven to be particularly sensitive to CPFA. Studies have revealed
that...
Cyclopropenoid fatty acids (CPFA), which are a group of
fatty acids produced by plants of the order Malvales, are known
to induce adverse physiological effects when administered to a
variety of animal species. A structurally strained cyclopropene
ring is present in all CPFA and is believed responsible for the
toxic...
A heat stable protease was identified as the cause of textural degradation in cooked arrowtooth flounder (Atheresthes stomias) muscle. Maximum proteolytic activity in the fish muscle was observed between 55°C and 60°C and myosin heavy chain appeared to be the primary substrate for the enzyme. Degradation of this myofibrillar protein...
The effect of different blanching treatments and
packaging materials on the enzymatic (lipoxygenase and
peroxidase) activity and fatty acid stability of two
different varieties of sweet corn on the cob (Jubilee and GH
2684) was evaluated during nine months of frozen storage at
-23.3°C.
The initial moisture content in the...
The DNA repair capabilities of rainbow trout (Salmo gairdneri)
were studied vising the method of autoradiography. Trout were fed a
semi-purified control diet containing 0 ppm, 50 ppm, or 300 ppm
cyclopropenoid fatty acids (CPFA) for 6-9 weeks. Liver slices were
prepared and exposed in vitro to a control treatment,...
Three studies were conducted to determine the effects of
cyclopropenoid fatty acids (CPFA) on the membrane components of livers
of rainbow trout (Salmo gairdneri). In the first study, ¹⁴C-sterculic
acid was administered by intraperitoneal injection into rainbow trout
and the trout maintained for 72 hours. The labelled sterculic acid
was...
The induction of drug-metabolizing enzymes is a
complex biochemical process manifested not only by
increases in various cytochrome P-450 isozymes and
related activities, but also by alterations in
endoplasmic reticulum membranes. Little work has been
done to examine how cytochrome P-450 inducing agents
influence other cellular processes, such as
phospholipid...