Humans and rodents experience declines in reference (long-term) and working (short-term)
memory and cognitive flexibility during the aging process. Aging changes in GluN1 and
GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both
reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor...
A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory
E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331
Humans and rodents experience declines in reference (long-term), working (short-term) memory, and...
Full Text:
Microsoft PowerPoint - EmilyEscobedo Research Poster 2013
A
A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory
E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331
Humans and rodents experience declines in reference (long-term), working (short-term) memory, and...
Full Text:
, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory
E. R. Escobedo1, K. Magnusson2,3
Humans and rodents experience declines in reference (long-term) and working (short-term)
memory and cognitive flexibility during the aging process. Aging changes in GluN1 and
GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both
reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor...
Full Text:
,
LIPOPOLYSACCHARIDE, CAN MIMIC
THE EFFECTS OF AGING ON
SPATIAL REFERENCE MEMORY
EmilyR. Escobedo, Kathy R
Humans and rodents experience declines in reference (long-term) and working (short-term)
memory and cognitive flexibility during the aging process. Aging changes in GluN1 and
GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both
reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor...
A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory
E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331
Humans and rodents experience declines in reference (long-term), working (short-term) memory, and...
Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Age-related diseases have been associated with chronic inflammation and impaired immune response, one of the hallmarks of aging. Aging individuals also have a higher susceptibility to zinc deficiency. The effects of zinc deficiency share many commonalities with the effects of aging on the immune system and zinc deficiency may be...
This thesis offers a textual analysis of Emily Bronte's
novel Wuthering Heights and, to a lesser extent, her poems
in an effort to understand fully the complicated
relationship of gender to time that characterizes her
artistic imagination.
The study emphasizes the interplay of religious,
psychological and sexual forces inherent in...
During fall term of 2015 and winter and spring term of 2016 I assisted in research within Dr. Emily Ho’s lab. The project that I assisted in looked at the effects of low zinc status and arsenic exposure in mice. Zinc is an essential micronutrient involved in numerous cellular processes...
Purpose: Many programs are available to engage people in health-promoting behaviors or behavior change, but most target specific behavior outcomes (e.g., weight loss, smoking cessation) rather than wellness. This study aimed to assess the effectiveness of a tracking-based health challenge focused on overall wellness, with or without peer support.
Methods:...
Purpose:
The xanthophyll carotenoids lutein and zeaxanthin are concentrated in the macula lutea of the retina. It is thought that the two plant pigments may play a role in preventing the development of age-related macular degeneration (AMD). Exposure to damaging light plays a role in retinal deterioration and AMD. The...
Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
The consumption of cruciferous vegetables is associated with several health benefits, including cancer prevention. Many of these benefits are attributed to the phytochemical, sulforaphane (SFN), which is derived from cruciferous vegetables such as broccoli and broccoli sprouts. These vegetables contain glucoraphanin (GFN), SFN’s precursor, which is converted to SFN by...
Sulforaphane is an isothiocyanate derived from cruciferous vegetables and has been under investigation as a cancer chemopreventive agent for over two decades. The compound is well tolerated and has been shown to slow cancer progression in several different pre-clinical models of carcinogenesis, such as of the lung, breast and colon....
Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...
One of the main ways that one can accurately gain knowledge of the experiences of students on a college campus is to talk to the students themselves. In this study, we used Photovoice, a participatory action approach, to help better understand the experiences of the students at Oregon State University...
Prostate cancer risk is significantly lower in Asian countries compared to the US, which has prompted interest in the chemo-preventative action of dietary components such as soy and green tea commonly found in Asian diets, such as soy and green tea. Studies have suggested that soy isoflavones and green tea...
Zinc is an essential mineral that is integral to many proteins and transcription factors that regulate key cellular functions. The normal prostate accumulates high concentrations of zinc; however, malignant tissues have significantly lower zinc levels. This unique relationship between zinc and the prostate has sparked interest in the role of...
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Emily Ho
Zinc is an essential mineral that is integral to many proteins and transcription
Surface waves play a vital role in air-sea interactions, and being able to easily measure them in-situ validates and improves predictive models. Here, we diagnose surface wave properties in the Bay of Bengal using modified vertical SOLO II profiling floats, which are regularly used as part of the Argo ocean...
The southwest monsoon, which may be idealized as the northward movement of the intertropical convergence zone in the Indian Ocean associated with differential heating of land and ocean, brings a seasonal reversal of currents and winds in the Bay of Bengal and the Arabian Sea. Atmospheric convection from monsoon activity...
Pancreatic beta cells produce and release insulin, a vital hormone that regulates blood glucose levels, and their dysfunction contributes to the development of diabetes mellitus. Dietary zinc deficiency and exposure to the toxicant inorganic arsenic have both independently been associated with diabetes, although the effects of their combination on pancreatic...
Parasitic infections and immune challenges can affect host reproductive fitness and, ultimately, the evolution of host populations in a myriad of ways. The fitness implications of parasitic infections range from increased host mortality to subtle changes in reproductive investment. From alterations of behaviors, sexual signaling, and competitive ability to changes...
Collaborative governance plays a significant role in forest management on public land in the Pacific Northwest. The method of governance offers the unique ability to engage a diverse range of stakeholders to reach consensus regarding forest management action. Evaluating the dynamics of the collaborative and its members is essential to...
Managing riparian areas in the dry forests of the intermountain west for diverse public values can create conflict, potentially limiting social acceptance in landscape-scale restoration projects. This thesis examined accelerated landscape-scale restoration as part of a broader shift toward ecosystem management on national forestland, which incorporates social values into forest...
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Emily Jane Davis
Managing riparian areas in the dry forests of the intermountain west for
Natural resource challenges in the American West feature a suite of actors and processes operating at different spatial and political scales, and crossing several administrative jurisdictions. I applied concepts of new environmental governance to Oregon’s greater sage-grouse (Centrocercus urophasianus) conservation strategy, focusing, in particular, on features of voluntary conservation arrangements...
This thesis is an offering, request, testimonio, refusal, and compliance to the discipline of anthropology and higher education. In this thesis, I engage with different forms of storytelling to highlight the relationships of mixed-status families in the United States. To accomplish this, I draw on the experiences of my mother...
Informal higher education science learning programs are increasingly being used as a tool to build scientific research capacity. However, there is low understanding of the impact that these programs on their target audiences, which is important to future capacity building efforts and program design. The purpose of this research project...
This study addressed the following question: "How does facilitating informal explorations with friends and family outside of a science course help students who are enrolled in the course?" The context was a physics course for prospective elementary and middle school teachers. This was a qualitative study that analyzed student responses...
The individual through earliest recorded history reveals contradictory views of the
human life-span. "Am I a free and unique individual, able to make choices and decide my
own destiny?, or, "Am I only a victim of circumstance, a speck of dust in the universe's
whirlwind of fate?"
Each view is...
For the last 30 years, the population of Mexico has grappled with overweight, obesity, and associated chronic diseases, such as type-2 diabetes and hypertension. To standardize care among healthcare providers and dietitians, an official nutritional guideline was published in the early 2000s, which included a non-modifiable food-based dietary guideline in...
Animals can be naturally exposed simultaneously to multiple stressors. These include habitat changes, contaminants, diseases, invasive species, parasitism, and predation. Exposure to various combinations of biotic and abiotic stressors may induce behavioral changes that affect the way an individual interacts within its environment.Like other groups of organisms, amphibians are exposed...
The purpose of the study was to investigate the effectiveness of therapeutic non- directive play treatment with third grade boys who were low achievers in reading and to determine how treatment was associated with changes in reading achievement: vocabulary and comprehension; reading attitude and academic self-concept; role expectations and self-adequacy....
About one-quarter of the U.S. adult population lives with a disability, yet ableist presentations of disability as a tragedy in need of a cure (i.e., the medical model) continue to predominate, even in higher education. Previous, qualitative research showed that people with disabilities (PWDs) desire changes in individual and societal...
Mutualistic associations between corals and symbiotic microalgae of the genus Symbiodium power tropical reef ecosystems, hotspots of marine biodiversity that buffer coastlines, support tourism- and fisheries-based economies, and offer untapped potential for discovery of novel pharmaceutical compounds. However, reef ecosystems are declining at an alarming rate, in large part due...
Camelids are known for frequent occurrence of general ill-thrift. In other species, neutrophil dysfunction has been identified as a cause of ill-thrift, and linked to chronic fungal and bacterial infections. However, no reference values exist for neutrophil function testing in camelids, which inhibits accurate evaluation of neutrophil deficiency in this...
The lionfish (Pterois volitans) is a successful invasive predator with large impacts on native fish populations in the western Atlantic. Lionfish predation may affect competition between prey species so it is important to understand whether lionfish display preferences between prey species. I investigated lionfish and native graysby grouper prey preference...
Glycomacropeptide (GMP) is a bioactive peptide found in the dairy product whey, along with whey protein isolate (WPI). Past studies have shown that digested GMP retains bioactivity in rodent guts. This study tested whether GMP or GMP-derived peptides or whey protein or whey protein-derived peptides inhibit pro-inflammatory cytokines. THP-1 cells...
The prevalence of obesity is increasing worldwide, causing a subsequent increase in insulin resistance (IR), metabolic disorders, and cardiovascular diseases. Although these conditions significantly impact both the individual and society, their etiologies have not been discovered, inhibiting potential prevention and treatment. Alterations to mitochondrial metabolism are implicated in the development...
Understanding how N availability influences base cation stores is critical for long-term ecosystem sustainability. Indices of nitrogen (N) availability and the distribution of nutrients in plant biomass, soil, and soil water were examined across ten young, unpolluted Douglas-fir (Pseudotsuga menziesii) stands in the Oregon Coast Range spanning a three-fold soil...
Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
There is limited information available on production of trailing blackberry, particularly certified organic plantings, which are of interest to growers as there is increased consumer demand and a price premium over conventionally-produced fruit. Various production strategies were evaluated for their effect on yield, biomass production, carbon (C), and nutrient concentrations...