Skeletal muscle damage induced by lengthening ("eccentric" or
"pliometric") contractions cause an immediate loss in maximal tetanic force (P₀) and an increase in protein degradation by unidentified endogenous mechanisms.
We hypothesized that increased proteolysis following active lengthening injury is
mediated by the Ca²⁺ dependent protease calpain. To test this hypothesis...
Background:
Osteosarcoma (OS) is an aggressive and often fatal cancer that afflicts over 1000 humans and 10,000 dogs per year in the United States. Recent evidence suggests deregulation in the signaling triad, receptor activator of nuclear factor kappa B (RANK), its activating ligand (RANKL), and the RANKL inhibitor, osteoprotegerin (OPG)...
BACKGROUND: This investigation sought to elucidate the relationship between hepatocyte growth factor (HGF)–induced metastatic behavior and the tyrosine kinase inhibitors (TKIs) crizotinib and dasatinib in canine osteosarcoma (OS). Preliminary evidence of an apparent clinical benefit from adjuvant therapy with dasatinib in four dogs is described. METHODS: The inhibitors were assessed...
Background: Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6–12 months despite these treatments. Taurolidine, a derivative of taurine, has...
Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....
Background:
Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
Myosins are actin-based molecular motors that may have specialized trafficking and contractile functions in cytoskeletal compartments that lack microtubules. The postsynaptic excitatory synapse is one such specialization, yet little is known about the spatial organization of myosin motor proteins in the mature brain. We used a proteomics approach to determine...
Growing concerns over the rise of anthelmintic resistant populations of gastrointestinal nematodes (GINs) have led producers to look for alternative means of treatment. These sentiments have been echoed by organic producers, who are restricted from the use of synthetically derived anthelmintics in the US. Chicory has emerged as a potential...
BACKGROUND: The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. Particularly, the expression and function of 5HTR2A in canine osteosarcoma has...
Background
Bcl11b, previously CTIP2, is a zinc finger nuclear transcription factor involved in the development of keratinocytes, teeth, T lymphocytes, and nervous tissue. Expression of Bcl11b has been reported in human head and neck squamous cell carcinoma (HNSCC) and increased expression correlates with poorly differentiated tumors. This study aimed to...
Part 1:
White muscle disease (WMD), a degenerative muscle disease brought on by a deficiency of the essential trace nutrient selenium, is thought to be mediated by the protein Selenoprotein W (SeW). In its relationship with WMD, SeW, like many selenoproteins, binds to glutathione, serving some purpose in redox mechanisms...
Full Text:
Dr. KevinMarley
GSH Project
Dr. Samuel Bennett
Mr. Brian Arbogast
Dr. Max Deinzer
Financial
Part 1:
White muscle disease (WMD), a degenerative muscle disease brought on by a deficiency of the essential trace nutrient selenium, is thought to be mediated by the protein Selenoprotein W (SeW). In its relationship with WMD, SeW, like many selenoproteins, binds to glutathione, serving some purpose in redox mechanisms...
Full Text:
Dr. Rick Sheri
Dr. Ben Figard
Dr. KevinMarley
Dr. Phillip Whanger
Mrs. Judy Butler
Mrs. Wanda
Blastocystis spp. is a common intestinal parasite in humans and animals that has been associated with acute or chronic digestive disorders such as irritable bowel syndrome. Serotonin mediates intestinal motility, sensation, and secretory function in the normal intestinal tract. Serotonin (5-HT) signaling is decreased in animal models of colitis, as...
Research on natural environments, over the last decade, is replete with microbial diversity studies that used culture-independent approaches. The cloning and sequencing of the 16S rRNA genes has been the driving force in the expansion of awareness about the great diversity of previously undiscovered microorganisms. Well-known uncultured groups of microorganisms...
Acute phase protein (APP) measurement can be used to characterize and rapidly detect inflammation. Serum amyloid A (SAA) and haptoglobin (HP) may be useful for diagnostic and prognostic purposes in horses presenting for colic and other inflammatory diseases. The objective of this thesis was to evaluate the use of SAA...
The objective of this study was to elucidate the expression of signaling molecules associated with the Wnt signaling pathway in cartilage of prepubescent foals and determine their association with chondrocytes located at the osteochondral junction and cartilage canals. Our hypothesis was that increased expression of the components of the Wnt...
River plumes discharging into continental shelf waters have the potential to influence patchiness of larval fishes, prey, and gelatinous predators. Using a high-resolution plankton imaging system, we sampled larval fishes, copepods, and planktonic predators (ctenophores, hydromedusae, and siphonophores) across multiple freshwater pulses exiting the mouth of Mobile Bay (Alabama, USA)...
Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
The relative influences of trans-Pacific and regional atmospheric transport on measured concentrations of polycyclic aromatic hydrocarbons (PAHs), PAH derivatives [Nitro- (NPAH) and Oxy-(OPAH)], organic carbon (OC), and Particulate Matter (PM) less than 2.5 μm in diameter (PM₂.₅) were investigated in the Pacific Northwest, USA in 2010-2011. Ambient high volume PM₂.₅...
This is a bibliography of doctoral dissertations and masters' theses in forestry and related topics issued during the period from July 1981 through June 1990. The colleges and universities included are all accredited by the Society of American Foresters. The actual listings were supplied by the individual institutions. Topics covered...
The azalea lace bug (Stephanitis pyrioides Scott) is a recently detected invasive pest to the Pacific Northwest and has become a major concern in Oregon. It feeds on azaleas as well as rhododendrons causing stippling on the top side of leaves. The damage is aesthetically displeasing and affects plant vigor...
The serotonergic system plays a significant regulatory role in osteoblast differentiation and proliferation. Serotonin (five-hydroxytryptamine or 5HT) may promote or inhibit osteoblast proliferation depending upon the serotonin receptor isoforms expressed by the cell. Classically, 5HT receptor 1B (5HTR1B) reduces osteoblast proliferation by inhibiting phosphorylation of the cAMP response element binding...
Over the past 42 years clay smoking pipes have been excavated from two U.S. army posts, Fort Hoskins (35BE15) and Fort Yamhill (35PO75) and curated at Oregon State University. These two forts were established in Western Oregon in 1856 and by 1866 both had been decommissioned. Numerous theses have focused...
Millions of children are exposed to various types of violence throughout their school years. American children, by the time they are 18 years old, have seen more than 100,000 acts of violence on television alone. The effect of exposure to violence becomes a part of a child's life experience and...