Innovative nanoelectromechanical switches (NEMS) have the prospects to reduce device actuation voltages as compared to traditional semiconductor devices. Current research on NEMS seeks to avoid irreversible adhesion at the nanoscopic level, which results in device failure. Minimizing leakage currents and increasing device longevity are additional goals of this approach. The...
In October, 2016, presidential candidate Donald Trump released a document titled “Contract with the American Voter.” This document promised, among many things, that within his first 100 days of his potential presidency, he would repeal and replace Obamacare. When he was unable to fulfill that promise, he employed rhetorical tactics...
Stasis theory has long stood as a foundational pillar of Western rhetoric. It is an integral component of the canon of invention, and has been in existence since the times of ancient Greek scholars. However, it is currently facing a substantive challenge to its efficacy and its very existence. This...
As more wind farms are connected to the grid, the variable nature of wind energy begins to influence grid stability. Energy storage could help smooth the variable nature of wind energy. Laboratory demonstration and exploration of the interaction between different energy storage devices and wind energy could help improve and...
Miniature satellites called cubesats have been gaining increasing popularity in
both academic and private spaceflight ventures. NASA's Jet Propulsion Laboratory
has recently been accepting design proposals for a cubesat mission to Europa, where
solar and battery power would be inadequate power sources. In this thesis, a
radioisotope powered cubesat was...
Although science is widely accepted as a fundamental source of information underlying decisions about forest management and conservation, considerably less attention has been paid to the inevitable role that normative values and beliefs play in such decisions. This thesis highlights the normative dimensions of "ecological forestry," a strategy of forest...
Student conduct has become increasingly significant in higher education as demands to address campus safety, student behaviors, and classroom management are increasingly prominent. Existing research focuses on the efficacy of student conduct policies and practices, but has not established how individuals understand student conduct as a myth, or a concept...
The greater sage-grouse (Centrocercus urophasianus: hereafter; sage-grouse) population in Modoc County California is geographically isolated and has been subsidized by translocation to prevent inbreeding depression since 2005. Despite significant efforts to increase the population through translocations and habitat improvement by cutting encroaching western juniper (Juniperus occidentalis), only a single lek...
At a time of rapid global change, a socio-ecological system (SES) approach can provide a framework through which to quantify and communicate the risks and uncertainties of coupled human-natural systems. Islands, and tropical coral reef islands in particular, can be excellent models for SES research since they may be considered...
Conservation is, among other things, the expression of a relationship between humans and nonhuman nature. This relationship can be described empirically using the methods of social science, but it can also be prescribed in the form of philosophical arguments. Scholars in the field of environmental ethics have discussed and debated...
On January 8th, 2011 tragedy struck in Tucson, Arizona. A gunman opened fire on Representative Gabrielle Giffords' "Congress on Your Corner" event, wounding thirteen and killing six ("Arizona Shooting"). Four days later, President Obama spoke to a grieving crowd at the University of Arizona's McKale Memorial Center. This study seeks...
Traditional archives have excluded marginalized people (women, people of color, and LGBTQ+ people) from sharing their histories through socially just representations. Portrayals of oppressed people that do exist in traditional archives are from the lens of the white cis-heteronormative patriarchy, and justify a narrative of colonialism, oppression, and injustice. This...
The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
Quinone outside Inhibitor (QOI) fungicides are one of the most widely used fungicide classes (FRAC 11) in the world. This popularity is the result of their ability to effectively manage a wide array of economically important pathogen species on a broad range of crops. While having mostly preventative activity, some...
National Geographic’s June 2018 magazine titled “Planet or Plastic?” drew attention to a growing problem throughout the world: ocean plastic. The eight plastic-related articles in the magazine are an example of science communication as a critical method of not only disseminating information but also raising awareness of the marine debris...
Plant-pollinator mutualisms are one of the most prevalent and economically important mutualisms in nature. Like many other ecological systems, plant-pollinator communities are threatened by anthropogenic activity, both directly (e.g., habitat conversion and fragmentation) and indirectly (e.g., climate change). While we are aware of many of the activities that adversely impact...
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Full Text:
reflect a decrease in Ezh2.
Sulforaphane Decreases Ezh2 Expression in PC3 Prostate Cancer Cells
Chelsea
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Full Text:
decrease was seen in all three
treatment wells. Actin was used as a reference to ensure that the observed
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Full Text:
decrease was seen in all three
treatment wells. Actin was used as a reference to ensure that the observed
Prostate cancer is one of the most prevalent types of cancer in the U.S. and is among the leading causes of death in men of all races. One predictor of advanced prostate cancer and aggressive tumor behavior is the overexpression of the histone methyl transferase EZH2.
EZH2 functions in the...
Full Text:
reflect a decrease in Ezh2.
Sulforaphane Decreases Ezh2 Expression in PC3 Prostate Cancer Cells
Chelsea
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...
Dibenzo[def,p]chrysene (DBC) is a polycyclic aromatic hydrocarbon (PAH) and an IARC classified 2A probable human carcinogen. Mouse progeny transplacentally exposed to DBC have been shown to develop lung and liver tumors, with liver tumors developing predominantly in males later in life. Sulforaphane (SFN) is an isothiocyanate that plays a crucial...
Ecological domains seeking to understand the environment and the behavior of species have received little attention in machine learning (ML), despite the fact that environmental changes have a significant impact on humans as well as ecosystems. Some ecological problems can be formulated similarly to other common ML applications, but there...
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
We present a new high-precision, high-resolution record of atmospheric methane from the West Antarctic Ice Sheet (WAIS) Divide ice core covering 1000–1800 C.E., a time period known as the late preindustrial Holocene (LPIH). The results are consistent with previous measurements from the Law Dome ice core, the only other high-resolution...
We report a decadally resolved record of atmospheric CO₂ concentration for the last 1000 years, obtained from the West Antarctic Ice Sheet (WAIS) Divide shallow ice core. The most prominent feature of the pre-industrial period is a rapid ∼7 ppm decrease of CO₂ in a span of ∼20–50 years at...
Stable surface adhesion of cells is one of the early pivotal steps in bacterial biofilm
formation, a prevalent adaptation strategy in response to changing environments. In Pseudomonas
fluorescens, this process is regulated by the Lap system and the second messenger cyclic-di-GMP.
High cytoplasmic levels of cyclic-di-GMP activate the transmembrane receptor...
In recent years the conservation community has engaged in debate over value in nonhuman nature, especially as it relates to motivations for conservation. Many have expressed the assumption that more people are willing to support conservation when emphasis is placed on the human benefits of nonhuman nature, rather than the...
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
Full Text:
: a source and sink for polycyclic aromatic
hydrocarbons in the marine environment
Authors
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
Full Text:
: a source and sink for polycyclic aromatic
hydrocarbons in the marine environment
Authors
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
Full Text:
: a source and sink for polycyclic aromatic hydrocarbons in the marine 1
environment 2
Chelsea M
Polycyclic aromatic hydrocarbons (PAHs) on virgin polystyrene (PS) and PS marine debris led us to examine PS as a source and sink for PAHs in the marine environment. At two locations in San Diego Bay, we measured sorption of PAHs to PS pellets, sampling at 0, 1, 3, 6, 9...
Full Text:
: a source and sink for polycyclic aromatic hydrocarbons in the marine 1
environment 2
Chelsea M
OBJECTIVE: To evaluate the effectiveness of a 3-month treadmill desk intervention in eliciting changes in physical activity and sedentary behavior among overweight/obese office workers. METHODS: A randomized controlled trial was conducted among overweight/obese office workers (n=41; mean age = 40.1 ± 10.1 years) at a private workplace. Participants were randomly...
Trends and sources of lead (Pb) aerosol pollution in the North Pacific rim of North America from 1850 to 2001 are investigated using a high-resolution (subannual to annual) ice core record recovered from Eclipse Icefield (3017 masl; St. Elias Mountains, Canada). Beginning in the early 1940s, increasing Pb concentration at...
Contaminants used at low elevation, such as pesticides on crops, can be transported tens of kilometers and deposited in adjacent mountains in many parts of the world. Atmospherically deposited organic contaminants in the Sierra Nevada Mountains of California, USA, have exceeded some thresholds of concern, but the spatial and temporal...
Advances in trace gas analysis allow localised, non-atmospheric features to be resolved in ice cores, superimposed on the coherent atmospheric signal. These high-frequency signals could not have survived the low-pass filter effect that gas diffusion in the firn exerts on the atmospheric history and therefore do not result from changes...
We present high-resolution measurements of carbon monoxide (CO) concentrations from a shallow ice core of the North Greenland Eemian Ice Drilling project (NEEM-2011-S1). An optical-feedback cavity-enhanced absorption spectrometer (OF-CEAS) coupled to a continuous melter system performed continuous, online analysis during a four-week measurement campaign. This analytical setup generated stable measurements...