The relative rates of hydrogen abstraction from o-xylene,
o-diethylbenzene and a series of four benzocycloalkenes by trichloromethyl
radical were determined at 70°. The strain energies of the
hydrocarbons and the corresponding radicals were calculated. A good
correlation between the log of the relative rates and the calculated
changes in strain...
Image classification is a difficult problem, often requiring large training sets to get satisfactory results. However this is a task that humans perform very well, and incorporating user feedback into these learning algorithms could help reduce the dependency on large amounts of labeled training data. This process has already been...
Mental illness is a universal phenomenon, but cultural context has a profound influence on how it is perceived, classified, and treated. Most systematic research on public attitudes toward mental illness has been completed in Western societies. The emergence of multicultural psychotherapy in the West has helped professionals recognize the extent...
In standard training regimes, one assumes that the classes presented to a model constitute all of the classes that the model will encounter when it is deployed. In real deployment scenarios, however, a model can sometimes encounter situations or objects that it has never seen. When these scenarios are safety-critical,...
The fundamental aim of this study was to determine how Malaysians define both leisure
and recreation. Two ethnic groups, Chinese and Malays, and rural and urban variants of these
groups were included in the sample. The other objective was to determine if there were differences
in the definitions due to...
In this thesis, we introduce a novel Explanation Neural Network (XNN) to explain the predictions made by a deep network. The XNN works by embedding a high-dimensional activation vector of a deep network layer non-linearly into a low-dimensional explanation space while retaining faithfulness i.e., the original deep learning predictions can...
Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
In order to better characterize linker histone interactions with DNA, avian erythrocyte-specific linker H5 and the trypsin-resistant globular domain of H5 (GH5) were used in DNA binding studies. To begin, H5 displayed a considerably higher binding
affinity for DNA than the isolated globular domain (GH5), supporting the importance of the...
Physical Activity (PA) has been shown to significantly improve the overall health of adolescents. The health dimensions that are positively influenced by a consistent level of PA are multiple and range from body composition, chronic diseases management (diabetes, cardiovascular disease, etc.), chronic pain, and mental health (depression, anxiety, etc.). The...
A current trend in educational reform requires teachers to be proficient in employing technology in their classrooms. As a result of this trend, teachers need to be prepared to integrate technology into their teaching, and teacher preparation programs have a responsibility to prepare their students accordingly. The handheld computer (PDA)...
The types and rates of label noise in real-world data sets present a challenge to machine learning projects. In this thesis, we propose a novel approach to address this issue. Our method combines a noise modelling technique for correcting label noise across the entire data set with a robust loss...
This paper discusses opportunities for developments in spatial clustering methods to help leverage broad scale community science data for building species distribution models (SDMs). SDMs are critical tools that inform the science and policy needed to mitigate the impacts of climate change on biodiversity. Community science data span spatial and...
Zinc is an important micronutrient involved in many cellular processes, including those part of immune function; however, about 15% of the US population is at risk for marginal zinc deficiency. This can lead to immune system complications including the generation of inflammatory cytokines. Aging is another factor that worsens the...
Crowdsourcing is a popular paradigm to address the high demands for labeled data in big data deluge. It aims to produce accurate labels by effectively integrating noisy, non-expert labeling from crowdsourced workers (annotators). The machine learning community has been studying effective crowdsourcing methods for many years, and many models and...
Many conditions affecting hydrogen (H₂) production by the cyanobacterium, Synechocystis sp. PCC 6803, were optimized to yield maximum H₂ accumulation. Biological H₂ production from photosynthetic species is a promising form of renewable energy since an abundant supply of sunlight hits the Earth every day, and photosynthetic bacteria can harness this...
Known as the fourth industrial revolution, digitization is an ongoing trend in all fields, in which various industries are integrating information technologies to support and improve their businesses. Nuclear technology industries have also increased their interest in data-driven methods by leveraging the potential of pattern recognition to identify anomalies and...
Bayesian Optimization (BO) methods are often used to optimize an unknown function f(•) that is costly to evaluate. They typically work in an iterative manner. In each iteration, given a set of observation points, BO algorithms select k ≥ 1 points to be evaluated. The results of those points are...
DHA (22:6,ω3), but not EPA (20:5,ω3), attenuates Western diet (WD)-induced hepatic fibrosis in a Ldlr[superscript −/−] mouse model of nonalcoholic steatohepatitis. We examined the molecular basis for the differential effect of dietary EPA and DHA on WD-induced hepatic fibrosis. DHA was more effective than EPA at preventing WD-induced effects on...
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cells . —Lytle, K. A., C. M.
Depner, C. P. Wong, and D. B. Jump. Docosahexaenoic acid
attenuates
The advancement of artificial intelligence (AI) has led to transformative developments across multiple sectors, fostering innovation and redefining our interactions with technology. As AI matures and becomes integrated into society, it offers numerous opportunities to address global challenges and revolutionize a wide array of human endeavors. These advances are driven...
IoT networks can be viewed as collections of Internet-enabled physical devices and objects, embedded with sensor, actuator, computation, storage and communication components, that are capable of connecting and exchanging data to one another. In recent years, organizations have allowed more and more IoT devices to be connected to their networks,...
Many problems in ecology and conservation biology can be formulated and solved using machine learning algorithms for multi-label classification. This dissertation addresses three topics related to predicting the distributions of multiple species. It improves existing methods and proposes a new modeling paradigm to address the multi-species, multi-label problem. The first...
The continuous improvement of construction operations requires a systematic approach of monitoring and making appropriate control actions. However, the lack of real-time information hinders this workflow and eventually compromises timely and effective decision-making. Project managers spend a great deal of time and effort to solve problems emerging from lack of...
Sequential supervised learning problems arise in many real applications. This dissertation focuses on two important research directions in sequential supervised learning: efficient training and feature induction.
In the direction of efficient training, we study the training of conditional random fields (CRFs), which provide a flexible and powerful model for sequential...
In this comprehensive thesis, we present a series of experiments and findings that highlight the
critical importance of TDC Voltage Sensors in the hardware security domain. Our research begins
by introducing a novel self-calibrating module, demonstrating its efficiency through preliminary
calibration tests. We then delve into the Peak-to-Peak tests, which...
With the advent of Artificial Intelligence (AI) in every sphere of life in today's day and age, it has become increasingly important for non-AI experts to be able to comprehend the underlying logic of how AI systems work, assess them and find faults in these systems, particularly when they are...
We consider the problem of supervised classification of bird species from audio recordings in a real-world acoustic monitoring scenario (i.e. audio data is collected in the field with an omnidirectional microphone, without human supervision). Obtaining better data about bird activity can assist conservation efforts, and improve our understanding of their...
An ability to meet the changing demands associated with development
promotes purpose in life, a defining feature of psychological well-being. Midlife
adults consistently report higher purpose in life compared to older adults. However,
less is known about the dynamics of purpose in life in the transition from middle to
older...
Aggressive random testing tools (“fuzzers”) are impressively effective
at finding compiler bugs. For example, a single test-case
generator has resulted in more than 1,700 bugs reported for a single
JavaScript engine. However, fuzzers can be frustrating to use:
they indiscriminately and repeatedly find bugs that may not be severe
enough...
In recent decades, the concept of transnational higher education has flourished and international branch campuses (IBCs) have proliferated. Some countries have gone as far as designating areas as education hubs and have attracted foreign universities to operate branch campuses on their soils. While researchers have studied what motivates universities to...
Advanced low power devices promote the development of micro power generators (MPGs) to replace the batteries to power them. Due to the trend in decreasing integrated circuit (IC) supply voltages, power supply designers are facing more and more serious challenges. The objective of this research is to design a power...
Soft magnetic composites, consisting of fine metallic particles in a non-magnetic, insulating matrix, have great potential for integrated inductor and antenna applications. The dielectric and magnetic properties of soft magnetic composites can be tailored by the choice of matrix as well as particle composition, size, and concentration for reduction in...
The various solution-based processes, spin coating, inkjet printing, microreactor assisted nanoparticle deposition (MANDTM) and spin-successive ionic layer absorption and reaction (Spin-SILAR) were used to demonstrate thin film electronics and anti-reflective coatings. Several aspects of thin film transistors (TFTs) were tested including a range of temperatures, annealing atmosphere, and deposition methods....
In this dissertation, my research work on excited state dynamics of small organic molecules in solutions is presented. Using femtosecond stimulated Raman spectroscopy (FSRS) as the main experimental tool, the excited state hydrogen-bonding dynamics (ESHBD) of Coumarin 102, a common laser dye molecule, in ethanol solution is examined with <150...
High-pressure torsion (HPT) is an effective severe plastic deformation (SPD)
technique to produce bulk nanostructured materials (BNMs). These BNMs often show a combination of exceptional mechanical and physical properties. Processing of single metals and alloys by HPT has been understood that the homogenous microstructures can be achieved throughout the disk...
To become a competitor for fossil fuels such as coal, solar installations will need to be produced and installed at a price equal to or below grid parity. This price can be approached by either reducing the overall system cost or increasing system efficiency. The focus of this paper is...
Analysis of observations on sequential events over time is common in real life. Sequential measurements over time describing the behavior of systems are usually called time series data, which have been collected in a wide range of disciplines. Over the years there have been multiple research areas in studying stochastic...
Networks of distributed, remote sensors are providing ecological scientists with a view of our environment that is unprecedented in detail. However, these networks are subject to harsh conditions, which lead to malfunctions in individual sensors and failures in network communications. This behavior manifests as corrupt or missing measurements in the...
Epigenetic changes, including aberrant DNA methylation, result in altered gene expression and play an important role in
carcinogenesis. Phytochemicals such as sulforaphane (SFN) and 3,3'-diindolylmethane (DIM) are promising chemopreventive
agents for the treatment of prostate cancer. Both have been shown to induce re-expression of genes, including tumor
suppressor genes silenced...
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Methylation in Normal Prostate Epithelial Cells and Prostate
Cancer Cells
Wong CP, Hsu A, Buchanan A
Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
We use femtosecond stimulated Raman spectroscopy (FSRS) to illuminate the choreography of intermolecular excited-state proton transfer (ESPT) of photoacid pyranine (8-hydroxypyrene-1,3,6-trisulfonic acid, HPTS) in water. The multidimensional reaction coordinate responsible for photoacidity is revealed to involve sequential activation of characteristic skeletal motions during the ca. 1 ps preparation stage preceding...
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
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the colon
Praveen Rajendran1, Wan-Mohaiza Dashwood1, Li Li1, Yuki Kang2, Eunah Kim1, Gavin Johnson1
A major difficulty in modeling multiphase flow in porous media is the emergence of trapped
phases. Our experiments demonstrate that gas can be trapped in either single-pores, multipores, or in large
connected networks. These large connected clusters can comprise up to eight grain volumes and can contain
up to 50%...
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presence of thin adsorbed water films, see Wong et al., 1992]. For a three-phase-system
with a simple-cubic
A novel table-top, microreactor-assisted nanomaterial deposition (MAND™) process, which combines the merits of microreaction technology with solution-phase nanomaterial synthesis and film deposition, was used to grow a nanostructured ZnO anti-reflective coating on a textured silicon substrate from aqueous solution. The subwavelength, anti-reflective nanostructures mimicked the structure and performance of the...
From June 2009 to July 2010, we conducted 27 continuous-flow surveys of surface water CO₂ partial pressure (pCO₂) along the longitudinal axis of the Neuse River Estuary (NRE), North Carolina ranging from the tidal freshwater region to the polyhaline border with the Pamlico Sound. Lateral transects were also conducted at...
Ambient ultraviolet-B radiation can harm amphibian eggs, larvae and adults. However, some amphibians avoid UV-B radiation when given the opportunity. The strawberry poison dart frog, Oophaga pumilio, is diurnal and males vocalize throughout the day in light gaps under forest canopies that expose them to solar radiation. Previous studies have...
Transportation systems are facing safety and operational challenges with a cost of billions of dollars annually in lost production time and wasted fuel. Infrastructure expansion, previously held as a panacea to most transportation challenges has lost its appeal due to financial, land-use and environmental constraints. Interest is surging in intelligent...
The biogeochemical processes that occur in marine sediments on continental margins are complex; however, from one perspective they can be considered with respect to three geochemical zones based on the presence and form of methane: sulfate-methane transition (SMTZ), gas hydrate stability zone (GHSZ), and free gas zone (FGZ). These geochemical...
BACKGROUND: Low levels of moderate-to-vigorous physical activity are associated with adverse health consequences.
OBJECTIVE: The intent of the study was to determine the feasibility and efficacy of a 12-week physical activity promotion program
targeting children, which was delivered to parents through mobile phones.
METHODS: Potential participants were recruited through advertisements...
Many applications in computer graphics and geometry processing rely on the ability to
locally orient 2D and 3D entities on a surface, or inside a volume, such as the sinusoidal
kernels in Gabor noise, the color and geometry textures in pattern synthesis, and the
finite elements in remeshing. In these...