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Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
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treated with DMSO, 0.1% (v/v), TCDD (1 nM),
or raloxifene (20 and 30mM, respectively) for 4h. Bars
Methods have been developed to measure the time required to
complete replication of an adenovirus DNA molecule and the time
between rounds of replication of the viral genomes. These methods
show that 22 minutes are required to complete replication of an
adenovirus DNA molecule at 37° C and that this...
The effects of household exposure to cigarette smoke on the incidence of respiratory illness were examined among 1007 18 month old children at Lu-wan District, Shanghai City, People's Republic China. The passive smoking quantity was estimated by summing the total daily cigarette consumption of family members. No mothers who smoked...
Superpopulation capture–recapture models are useful for estimating the abundance of long-lived, migratory species because they are able to account for the fluid nature of annual residency at migratory destinations. Here we extend the superpopulation POPAN model to explicitly account for heterogeneity in capture probability linked to reproductive cycles (POPAN-τ). This...
Aims:
While lateral root mass is readily detectable with ground penetrating radar (GPR), the roots beneath a tree (below-stump) and overlapping lateral roots near large trees are problematic for surface-based antennas operated in reflection mode. We sought to determine if tree size (DBH) effects GPR root detection proximal to longleaf...
During SHEBA, thin ice and freshening of the Arctic Ocean surface in the Beafort Sea led to speculation that perennial sea ice was disappearing [McPhee et al., 1998]. Since 1987, we have collected salinity, δ¹⁸O and Ba profiles near the initial SHEBA site and, in 1997, we ran a section...
Biodegradable poly(ethyleneglycol)-poly(valerolactone)-poly(ethyleneglycol) [PEG-PVL-PEG] copolymers were synthesized through ring opening polymerization of δ-valerolactone (VL) followed by the coupling of monomethoxy poly(ethyleneglycol-poly(valerolactone) (mPEG-PVL) with hexamethylene diisocyanate (HDI). The copolymers were characterized by ¹H NMR, FT-IR, and GPC. Block copolymers of PEG and PVL with different VL/PEG molar ratios were successfully synthesized. One...
Aerobic oxidation is important in the cycling of methane in the sediments of Lake Washington. About half of the methane flux from depth is oxidized to CO, in the upper 0.7 cm of the sediments and the remainder escapes into the water column. In terms of the total carbon budget...
Chemical and microbial soil properties were assessed in paired unfertilized and urea fertilized (>89 g N·m–2) plots in 13 second-growth Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) stands distributed throughout western Washington and Oregon. A decade following the termination of fertilization, fertilized plots averaged 28% higher total N in the O layer...