A two-part study was conducted with three poorly water soluble
drugs (phenylbutazone, tolbutamide, theophylline) to develop two new
drug delivery systems based on physical-chemical approaches.
In the first part, tolbutamide and phenylbutazone were made into
solid dispersions with various excipients using a lyophilization
technique. In vitro dissolution studies of these...
Dissolution profiles of two commercial products (Motrine and Rufen®) were analyzed and compared at 8 pH levels, ranging from pH 2.0 to pH 8.0. It was demonstrated, as expected, that the rate and extent of ibuprofen dissolution dissolution was pH dependent. In vitro dissolution characteristics of the ibuprofen solid dispersion...
An oral Vibrio vaccine for salmonids was developed.
The vaccine was produced by spray coating lyophilized
formalin-killed whole cells of Vibrio anguillarum (VA LS 1-
74) onto non-pareil sugar beads. Then methacrylic acrylic
acid copolymer (Eudragit L-30D) was applied as an enteric
protective coating.
Using x-ray radiographic techniques, it was...
Sustained concentrations of active compound were maintained
in vitro and in vivo for an oral and a parenteral dosage form
respectively. The vehicle of a oral dosage form was modified and the
molecular structure of a parenteral dosage form was modified. An oral
dosage form was tested in vitro using...
The disposition of four therapeutically important antimicrobial agents was studied in llamas following intravenous bolus administration. Six llamas were each given ampicillin, tobramycin, trimethoprim and enrofloxacin at a dose of 12 mg/kg, 1 mg/kg, 3 mg/kg and 5 mg/kg of body weight with a wash out period of 3 days...
Oral administration is the most practical way of vaccination of fish. It has advantages over intraperitoneal injection and immersion methods that include no stressful handling, no interference with routine fish husbandry and antigens can be delivered to the fish in their feed.
An oral antigen delivery system was developed for...