Effects of lactobacilli in enteric coated capsules
were studied in piglets (Chapter I). Lactobacillus
acidophilus and Lactobacillus bulgaricus isolated from a
commercial product were formulated in capsules, enteric
coated, and then given to both Escherichia coli-challenged
and unchallenged baby pigs. Decreased
incidence and severity of diarrhea, and decreased weight
deceleration...
Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
This dissertation describes two different projects. The first is the development of an oral DNA vaccine delivery system for fish. A novel oral DNA vaccine delivery system was developed for Rainbow Trout by combining non-viral vectors (polycationic liposomes or polycationic polymer) to facilitate the DNA vaccine's uptake by cell membranes...