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- Creator:
- Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
- Abstract:
- Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
- Full Text:
- OR 97331, USA 8 ‡Superfund Research Center, Oregon State University, Corvallis, OR 97331, USA 9
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- Creator:
- Madeen, Erin, Corley, Richard A., Crowell, Susan, Turteltaub, Kenneth, Ognibene, Ted, Malfatti, Mike, McQuistan, Tammie J., Garrard, Mary, Sudakin, Dan, and Williams, David E.
- Abstract:
- Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
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- dietary intake of 280 ng per 70 kg individual with 700 ng considered as a high-level intake.9 Finally, a
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- Creator:
- Filichkin, Sergei A., Breton, Ghislain, Priest, Henry D., Dharmawardhana, Palitha, Jaiswal, Pankaj, Fox, Samuel E., Michael, Todd P., Chory, Joanne, Kay, Steve A., and Mockler, Todd C.
- Abstract:
- BACKGROUND: Circadian clocks provide an adaptive advantage through anticipation of daily and seasonal environmental changes. In plants, the central clock oscillator is regulated by several interlocking feedback loops. It was shown that a substantial proportion of the Arabidopsis genome cycles with phases of peak expression covering the entire day. Synchronized...
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- ; Accepted January 15, 2011; Published June 9, 2011 Copyright: � 2011 Filichkin et al. This is an open
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- Creator:
- Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
- Abstract:
- The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
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- ** ** ** * 4.0 3.0 2.0 1.0 0.0 Lean Obese R el at iv e ex pr es si on FX R Sh p Fg f1 9 ** ** a
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- Creator:
- O'Neill, Kate A., Murphy, Michael F. G., Bunch, Kathryn J., Puumala, Susan E., Carozza, Susan E., Chow, Eric J., Mueller, Beth A., McLaughlin, Colleen C., Reynolds, Peggy, Vincent, Tim J., Von Behren, Julie, and Spector, Logan G.
- Abstract:
- Background: High birthweight is an established risk factor for childhood leukaemia. Its association with other childhood cancers is less clear, with studies hampered by low case numbers. Methods: We used two large independent datasets to explore risk associations between birthweight and all subtypes of childhood cancer. Data for 16 554...
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- *† Michael FG Murphy,2,4† Kathryn J Bunch,3,4 Susan E Puumala,5 Susan E Carozza,6 Eric J Chow,7 Beth A
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- Creator:
- Jacobson, Terry A., Maki, Kevin C., Orringer, Carl E., Jones, Peter H., Kris-Etherton, Penny, Sikand, Geeta, La Forge, Ralph, Daniels, Stephen R., Wilson, Don P., Morris, Pamela B., Wild, Robert A., Grundy, Scott M., Daviglus, Martha, Ferdinand, Keith C., Vijayaraghavan, Krishnaswami, Deedwania, Prakash C., Aberg, Judith A., Liao, Katherine P., McKenney, James M., Ross, Joyce L., Braun, Lynne T., Ito, Matthew K., Bays, Harold E., Brown, W. Virgil, Underberg, James A., and NLA Expert Panel
- Abstract:
- An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
- Full Text:
- Clinical Lipidology (2015) 9, S1–S122 National Lipid Association Recommendations - Part 2 National Lipid
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- Creator:
- McPhillie, Martin, Zhou, Ying, El Bissati, Kamal, Dubey, Jitender, Lorenzi, Hernan, Capper, Michael, Lukens, Amanda K, Hickman, Mark, Muench, Stephen, Verma, Shiv Kumar, Weber, Christopher R., Wheeler, Kelsey, Gordon, James, Sanders, Justin, Moulton, Hong, Wang, Kai, Kim, Taek-Kyun, He, Yuqing, Santos, Tatiana, Woods, Stuart, Lee, Patty, Donkin, David, Kim, Eric, Fraczek, Laura, Lykins, Joseph, Esaa, Farida, Alibana-Clouser, Fatima, Dovgin, Sarah, Weiss, Louis, Brasseur, Gael, Wirth, Dyann, Kent, Michael, Hood, Leroy, Meunieur, Brigitte, Roberts, Craig W., Hasnain, S. Samar, Antonyuk, Svetlana V., Fishwick, Colin, and McLeod, Rima
- Abstract:
- Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
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- , Kelsey Wheeler 2 , James Gordon 1 , Justin Sanders 9 , Hong Moulton 9 , Kai Wang 10 , Taek-Kyun
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- Creator:
- McPhillie, Martin, Zhou, Ying, El Bissati, Kamal, Dubey, Jitender, Lorenzi, Hernan, Capper, Michael, Lukens, Amanda K, Hickman, Mark, Muench, Stephen, Verma, Shiv Kumar, Weber, Christopher R., Wheeler, Kelsey, Gordon, James, Sanders, Justin, Moulton, Hong, Wang, Kai, Kim, Taek-Kyun, He, Yuqing, Santos, Tatiana, Woods, Stuart, Lee, Patty, Donkin, David, Kim, Eric, Fraczek, Laura, Lykins, Joseph, Esaa, Farida, Alibana-Clouser, Fatima, Dovgin, Sarah, Weiss, Louis, Brasseur, Gael, Wirth, Dyann, Kent, Michael, Hood, Leroy, Meunieur, Brigitte, Roberts, Craig W., Hasnain, S. Samar, Antonyuk, Svetlana V., Fishwick, Colin, and McLeod, Rima
- Abstract:
- Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
- Full Text:
- , Kelsey Wheeler 2 , James Gordon 1 , Justin Sanders 9 , Hong Moulton 9 , Kai Wang 10 , Taek-Kyun
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- Creator:
- Sasaki, Takahiko, Lynch, Kelsey L., Mueller, Caitlin V., Friedman, Steven, Freitag, Michael, and Lewis, Zachary A.
- Abstract:
- In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
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- at the Neurospora hH3 locus and a deletion of the Neurospora mus-51 gene. The DNA sequence of Fg hH3
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- Creator:
- Jackson, Alexis M., Semmens, Brice X., de Mitcheson, Yvonne Sadovy, Heppell, Scott A., and et al.
- Abstract:
- To address patterns of genetic connectivity in a mass-aggregating marine fish, we analyzed genetic variation in mitochondrial DNA (mtDNA), microsatellites, and single nucleotide polymorphisms (SNPs) for Nassau grouper (Epinephelus striatus). We expected Nassau grouper to exhibit genetic differentiation among its subpopulations due to its reproductive behavior and retentive oceanographic conditions...
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- (Epinephelus striatus), a Mass-Aggregating Marine Fish. PLoS ONE 9(5): e97508. doi:10.1371/journal.pone